dextro-mannitol

D-mannitol

CAS: 69-65-8 C6 H14 O6 MW: 182.17278000 odorless sweet

Identification

Namedextro-mannitol
IUPAC(2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
CAS Number69-65-8
EINECS200-711-8
FDA UNII3OWL53L36A
Molecular FormulaC6 H14 O6
Molecular Weight182.17278000
MDL NumberMFCD00064287
Nikkaji NumberJ2.369H
Beilstein1721898
XlogP3-3.10 (est)

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices180.25
JECFA Food AdditiveMannitol
GSFA CodexMannitol (421)
DG SANTE Food AdditivesD-mannitol
FDA Mainterm (SATF)69-65-8 ; MANNITOL
FDA RegulationFDA PART 100 -- GENERAL

Physical Properties

Appearance white crystalline powder (est)
Assay 96.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 164.00 to 168.00 °C. @ 760.00 mm Hg
Boiling Point 290.00 to 295.00 °C. @ 760.00 mm Hg
Flash Point 558.00 °F. TCC ( 292.50 °C. ) (est)
logP (o/w) -3.262 (est)
Soluble in acetic acid, slightly
Insoluble in ether

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesbinding agents

Organoleptic Properties

Odor Description at 100.00 %.
Taste Description sweet

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 13500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION\nGASTROINTESTINAL: NAUSEA OR VOMITING\nKIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"']

Safety in Use

Categorysweeteners, humectants, texturizers, stabilizers, bulking agents
Recommendation for dextro-mannitol usage levels up tonot for fragrance use.
Recommendation for dextro-mannitol flavor usage levels up tonot for flavor use.

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Potential Uses

binder in adhesives FL flavor enhancers humectants

Natural Occurrence

anise root barley root bay laurel root buckthorn sea buckthorn fruit caraway celery leaf celery plant celery root celery shoot celery stem cherry sour cherry fruit chicory plant cinnamon ceylon cinnamon plant coriander fruit cumin seed dandelion root leek wild leek plant lettuce plant not found in nature olive leaf onion bulb pomegranate leaf pomegranate pericarp pomegranate root pomegranate seed pomegranate stem pomegranate stem bark pomegranate twig raspberry red raspberry fruit

Synonyms

cordycepic acid cosmospheres GYAM-M diosmol (2R,3R,4R,5R)- hexan-1,2,3,4,5,6-hexol (2R,3R,4R,5R)- hexane-1,2,3,4,5,6-hexol (2R,3R,4R,5R)-1,2,3,4,5,6- hexanehexol invenex isotol maniton S maniton-s manna sugar mannazucker mannidex mannigen mannisol mannistol mannit D- mannit mannit p D- mannitol D(-)- mannitol mannitol granular USP mannitol powder USP mannogem 2080 marine crystal mushroom sugar osmitrol osmofundin osmosal resectisol rightsweet mannitol PubMed: Construction of an efficient Escherichia coli whole-cell biocatalyst for d-mannitol production. PubMed: [Determination of alditols in foods by ion chromatography-mass spectrometry]. PubMed: Solution behaviour and sweetness response of D-Mannitol at different temperatures. PubMed: [Production of D-mannitol by metabolically engineered Escherichia coli]. PubMed: [Determination of alditols in wine by gas chromatography-mass spectrometry after acetate derivatization]. PubMed: Characterization of plant-derived lactococci on the basis of their volatile compounds profile when grown in milk. PubMed: Engineering of photosynthetic mannitol biosynthesis from CO2 in a cyanobacterium. PubMed: [Method of quantitative analysis by HPLC and confirmation by LC-MS of sugar alcohols in foods]. PubMed: Differential trafficking of saccharidic probes following aspirin in clinical tests of intestinal permeability in young healthy women. PubMed: Signaling specificity provided by the Arabidopsis thaliana heterotrimeric G-protein γ subunits AGG1 and AGG2 is partially but not exclusively provided through transcriptional regulation. PubMed: Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG. PubMed: Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species. PubMed: Soy-derived di- and tripeptides alleviate colon and ileum inflammation in pigs with dextran sodium sulfate-induced colitis. PubMed: An international validation study of a Bhas 42 cell transformation assay for the prediction of chemical carcinogenicity. PubMed: Risperidone solid dispersion for orally disintegrating tablet: its formulation design and non-destructive methods of evaluation. PubMed: Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris. PubMed: Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. PubMed: Correlation of mannitol fermentation with virulence-associated genotypic characteristics in Vibrio vulnificus isolates from oysters and water samples in the Gulf of Mexico. PubMed: l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis. PubMed: Syntheses of dopa glycosides using glucosidases. PubMed: Inhibitory action of palatinose and its hydrogenated derivatives on the hydrolysis of alpha-glucosylsaccharides in the small intestine. PubMed: Lactobacillus ghanensis sp. nov., a motile lactic acid bacterium isolated from Ghanaian cocoa fermentations. PubMed: Generation of antibodies specific to D-mannitol, a unique haptenic allergen, using reductively aminated D-mannose-bovine serum albumin conjugate as the immunogen. PubMed: Amyloglucosidase-catalyzed synthesis of eugenyl and curcuminyl glycosides. PubMed: [Isolation and identification of a bacterial strain JS018 capable of degrading several kinds of organophosphate pesticides]. PubMed: Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme. PubMed: Antioxidant activity of Myristica malabarica extracts and their constituents. PubMed: Embryotoxic effects of CKD-602, a new camptothecin anticancer agent, in rats. PubMed: Inhibitors of carbohydrate metabolism reduce undirected song production at doses that do not alter food intake in singly housed male zebra finches. PubMed: Anaphylaxis to excipient mannitol: evidence for an immunoglobulin E-mediated mechanism. PubMed: Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol. PubMed: Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats. PubMed: Scale-up of a new bacterial mannitol production process. PubMed: Staphylococcus equorum subsp. linens, subsp. nov., a starter culture component for surface ripened semi-hard cheeses. PubMed: Inhibition of diphenolase activity of tyrosinase by vitamin b(6) compounds. PubMed: Age- and diet-related increase in transepithelial colon permeability of Fischer 344 rats. PubMed: Examining the relative timing of hydrogen abstraction steps during NAD(+)-dependent oxidation of secondary alcohols catalyzed by long-chain D-mannitol dehydrogenase from Pseudomonas fluorescens using pH and kinetic isotope effects. PubMed: Interactions of dietary fat and 2,5-anhydro-D-mannitol on energy metabolism in isolated rat hepatocytes. PubMed: High-fat diet prevents eating response and attenuates liver ATP decline in rats given 2,5-anhydro-D-mannitol. PubMed: Hydrogenation of fructose on Ru/C catalysts. PubMed: Determination of sugar alcohols in confectioneries by high-performance liquid chromatography after nitrobenzoylation. PubMed: Differentiation of Tetragenococcus populations occurring in products and manufacturing processes of puffer fish ovaries fermented with rice-bran. PubMed: Metabolic inhibitors synergistically decrease hepatic energy status and increase food intake. PubMed: Kinetic study of the catalytic mechanism of mannitol dehydrogenase from Pseudomonas fluorescens. PubMed: Liquid chromatographic determination of sugar alcohols in beverages and foods after nitrobenzoylation. PubMed: Neural substrate for an integrated metabolic control of feeding behavior. PubMed: Brain fos-like immunoreactivity in chronic decerebrate and neurologically intact rats given 2,5-anhydro-D-mannitol. PubMed: Metabolic inhibition increases feeding and brain Fos-like immunoreactivity as a function of diet. PubMed: Hyperpolarization of the rat hepatocyte membrane by 2,5-anhydro-D-mannitol in vivo. PubMed: Temporal relationships between eating behavior and liver adenine nucleotides in rats treated with 2,5-AM. PubMed: 2,5-Anhydro-D-mannitol induces Fos-like immunoreactivity in hindbrain and forebrain: relationship to eating behavior. PubMed: Effects of the fructose analog, 2,5-anhydro-D-mannitol, on food intake and estrous cyclicity in Syrian hamsters. PubMed: Hyperpolarization of hepatocytes by 2,5-AM: implications for hepatic control of food intake. PubMed: Intraportal infusion of 2,5-anhydro-D-mannitol increases afferent activity in the common hepatic vagus branch. PubMed: Glucoprivation attenuates the hypophagia induced by epinephrine in mice. PubMed: Influnce of oat saponins on intestinal permeability in vitro and in vivo in the rat. PubMed: Fatty acid oxidation modulates the eating response to the fructose analogue 2,5-anhydro-D-mannitol. PubMed: A comparison of the effects of food deprivation and 2,5-anhydro-D-mannitol on metabolism and ingestion. PubMed: Regulation of food intake by metabolic fuels in white-crowned sparrows. PubMed: Whole body energy expenditure and fuel oxidation after 2,5-anhydro-D-mannitol administration. PubMed: L-ethionine, an amino acid analogue, stimulates eating in rats. PubMed: Phosphate loading prevents the decrease in ATP and increase in food intake produced by 2,5-anhydro-D-mannitol. PubMed: Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve. PubMed: Increased feeding after treatment with fructose, but not glucose, antimetabolites in rats with dopamine-depleting brain lesions. PubMed: Insulin and IGE-1 receptors in a human intestinal adenocarcinoma cell line (CACO-2): regulation of Na+ glucose transport across the brush border. PubMed: Feeding modulation by pentose and hexose analogues. PubMed: 2,5-Anhydro-D-mannitol: its unique central action on food intake and blood glucose in rats. PubMed: 2,5-anhydro-D-mannitol acts in liver to initiate feeding. PubMed: Acetaldehyde stimulation of net gluconeogenic carbon movement from applied malic Acid in tomato fruit pericarp tissue. PubMed: DNA damage by smoke: protection by turmeric and other inhibitors of ROS. PubMed: Plasma osmolality predicts extracellular fluid catechol concentrations in the lateral hypothalamus. PubMed: A selective and diagnostic medium for use in the enumeration of Listeria spp. in foods. PubMed: 2,5-anhydro-D-mannitol: a fructose analogue that increases food intake in rats. PubMed: Fasting and refeeding modulate neutral amino acid transport activity in the basolateral membrane of the rat exocrine pancreatic epithelium: fasting-induced insulin insensitivity. PubMed: No evidence of carcinogenicity of D-mannitol and propyl gallate in F344 rats or B6C3F1 mice. PubMed: Vibrio furnissii (formerly aerogenic biogroup of Vibrio fluvialis), a new species isolated from human feces and the environment. PubMed: Bioavailability of glucose from Palatinit. PubMed: Absence of carcinogenic response in F344 rats and B6C3F1 mice given D-mannitol in the diet for two years. PubMed: Carcinogenesis Bioassay of D-Mannitol (CAS No. 69-65-8) in F344/N Rats and B6C3F1 Mice (Feed Study). PubMed: Atypical biogroups of Escherichia coli found in clinical specimens and description of Escherichia hermannii sp. nov. PubMed: Detection and growth of enteropathogenic Escherichia coli in soft ripened cheese.