Identification

Nameveratraldehyde
IUPAC3,4-dimethoxybenzaldehyde
CAS Number120-14-9
EINECS204-373-2
FDA UNIIUI88P68JZD
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00003363
Nikkaji NumberJ9.907D
Beilstein0473899
CoE Number106
XlogP31.50 (est)

Regulatory

JECFA Food Flavoring877 veratraldehyde
DG SANTE Food Flavourings05.017 veratraldehyde
FEMA Number3109
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)120-14-9 ; VERATRALDEHYDE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance yellow crystalline needles (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 42.00 to 45.00 °C. @ 760.00 mm Hg
Boiling Point 281.00 °C. @ 760.00 mm Hg
Congealing Point 40.00 °C.
Acid Value 2.00 max. KOH/g
Vapor Pressure 0.004000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 1.220
Soluble in ethyl alcohol, 1 part of 50% alcohol
Insoluble in paraffin oil

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength medium ,
Substantivity 400 hour(s) at 100.00 %
Odor Description
at 10.00 % in dipropylene glycol.
Sweet, creamy, vanillin, powdery, herbal with a slight phenolic nuance
caramel; cherry; creamy; woody; citrus; minty
very sweet, woody, vanilla and heliotrope notes
Sweet-vanilla, creamy, heliotropine, woody, coumarin
Taste Description
at 50.00 ppm.
sweet creamy vanilla
sweet aromatic, spicy, vanilla, creamy

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-mouse LD50 [sex: M] 3200 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ATAXIA\nGASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for veratraldehyde usage levels up to15.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)120.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)55.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

ACS International GmbH

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Augustus Oils Ltd

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Foreverest Resources Ltd.

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Indukern, S.A. F&F Ingredients Division

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Jiangyin Healthway International Trade Co., Ltd

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M&U International LLC

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Pell Wall Perfumes

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Sigma-Aldrich

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SRS Aromatics Ltd

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Potential Uses

FR cherry FR cream FR fruit FR heliotrope FR maple FR moss FR oriental FR vanilla FR woody

Natural Occurrence

champaca absolute (michelia alba dc.) @ 0.04% Data ginger peppermint leaf raspberry red raspberry fruit vanilla

Synonyms

benzaldehyde, 3,4-dimethoxy- 3,4- dimethoxy benzaldehyde 3,4- dimethoxy-benzaldehyde 3,4- dimethoxybenzaldehyde 3,4- dimethoxybenzene carbinol dimethyl ether protocatechualdehyde 3,4- dimethyloxybenzaldehyde methyl vanillin protocatechualdehyde dimethyl ether protocatechuec aldehyde dimethyl ether protocatechuic aldehyde dimethyl ether vanillin methyl ether vanillyl methyl ether veratraldehyde FCC veratraldehyde flakes veratric aldehyde p- veratric aldehyde para- veratric aldehyde veratrum aldehyde veratryl aldehyde veratryl aldehyde powder veratrylaldehyde (chunks) veratrylaldehyde congealed solid veratrylaldehyde powder US Patents: 4,657,700 - Fragrance compositions containing benzyl ethers PubMed: Use of benzo analogs to enhance antimycotic activity of kresoxim methyl for control of aflatoxigenic fungal pathogens. J-Stage: Characterization of Aryl Alcohol Oxidase Produced by Dye-Decolorizing Fungus, Geotrichum candidum Dec1 PubMed: Pseudomonas putida CSV86: a candidate genome for genetic bioaugmentation. J-Stage: Biotransformation of Benzaldehyde-Type and Acetophenone-Type Derivatives by Pharbitis nil Hairy Roots PubMed: Secondary organic aerosol production from aqueous reactions of atmospheric phenols with an organic triplet excited state. J-Stage: Isolation and Characterization of Aromatics-degrading Microorganisms from the Gut of the Lower Termite Coptotermes formosanus PubMed: Spectral and Molecular Modeling Studies on Hydroxybenzaldehydes with Native and Modified Cyclodextrins. J-Stage: BE-23372M, A NOVEL PROTEIN TYROSINE KINASE INHIBITOR III. SYNTHESIS PubMed: Investigation of spectroscopic behaviors of newly synthesized (2E)-3-(3,4-dimethoxyphenyl)-1-(2,5-dimethylthiophen-3-yl)prop-2-en-1-one (DDTP) dye. PubMed: 5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety. PubMed: Potent nematicidal activity of phthalaldehyde, salicylaldehyde, and cinnamic aldehyde against Meloidogyne incognita. PubMed: Metabolic characteristics of the species Variovorax paradoxus. PubMed: Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. PubMed: Combinatorial evaluation of laccase-mediator system in the oxidation of veratryl alcohol. PubMed: Cloning, expression and characterization of an aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium strain BKM-F-1767. PubMed: Synthesis of anti-HIV lithospermic acid by two diverse strategies. PubMed: Synthesis of novel biologically active heterocyclic compounds from 2-oxo-2H-benzopyran-6-yl-imidazolidine. PubMed: Phenolic compounds as enhancers in enzymatic and electrochemical oxidation of veratryl alcohol and lignins. PubMed: Microbial production of biovanillin. PubMed: Photoenhanced degradation of veratraldehyde upon the heterogeneous ozone reactions. PubMed: Racemization-free synthesis of (S)-(+)-tylophorine from L-proline by radical cyclization. PubMed: Oxidative cleavage of diverse ethers by an extracellular fungal peroxygenase. PubMed: A validated reverse-phase HPLC analytical method for the quantification of phenolic compounds in Baccharis dracunculifolia. PubMed: The total synthesis of fukiic acid, an HIV-1 integrase inhibitor. PubMed: Determination of some aldehydes by using solid-phase microextraction and high-performance liquid chromatography with UV detection. PubMed: Combinatorial synthesis and characterization of new asymmetric porphyrins as potential photosensitizers in photodynamic therapy. PubMed: A reliable quantitative method for the analysis of phenolic compounds in Brazilian propolis by reverse phase high performance liquid chromatography. PubMed: Spray-dried propolis extract, II: prenylated components of green propolis. PubMed: Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. PubMed: Alpha-monodeuterated benzyl alcohols and phosphobetaines from reactions of aromatic aldehydes with a water/D2O-soluble phosphine. PubMed: Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function. PubMed: Asymmetric synthesis of tetrahydropalmatine via tandem 1,2-addition/cyclization. PubMed: Characterization of aryl alcohol oxidase produced by dye-decolorizing fungus, Geotrichum candidum Decl. PubMed: Methyl jasmonate modulated biotransformation of phenylpropanoids to vanillin related metabolites using Capsicum frutescens root cultures. PubMed: Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. PubMed: Involvement of lipid peroxidation in the degradation of a non-phenolic lignin model compound by manganese peroxidase of the litter-decomposing fungus Stropharia coronilla. PubMed: Identification of phenolics for control of Aspergillus flavus using Saccharomyces cerevisiae in a model target-gene bioassay. PubMed: First synthesis of a polysaccharide-supported lignin model compound and study of its oxidation promoted by lignin peroxidase. PubMed: Lignin peroxidase-catalyzed oxidation of nonphenolic trimeric lignin model compounds: fragmentation reactions in the intermediate radical cations. PubMed: Isolation and characterization of aromatics-degrading microorganisms from the gut of the lower termite Coptotermes formosanus. PubMed: Electroenzymatic oxidation of veratryl alcohol by lignin peroxidase. PubMed: Properties and functional significance of Saccharomyces cerevisiae ADHVI. PubMed: Influence of aromatic compounds on biodegradation of [14C]-labeled xylan and mannan by the white-rot fungus Phlebia radiata. PubMed: [Dependence of activities of polysaccharide hydrolases and oxidases from Cerrena unicolor on the source of carbon and aromatic acids in culture media]. PubMed: A new cyclobutane lignan from Cinnamomum balansae. PubMed: Antioxidant properties of 8.0.4'-neolignans. PubMed: Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents. PubMed: Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene product as a broad specificity NADPH-dependent alcohol dehydrogenase: relevance in aldehyde reduction. PubMed: Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans. PubMed: Comparison of two assay procedures for lignin peroxidase. PubMed: Synthesis of N-[3,4-dimethoxyphenyl)propanoyl]pyrrole, a metabolite of Piper brachystachyum. PubMed: Lignin peroxidase initiates O2-dependent self-propagating chemical reactions which accelerate the consumption of 1-(3',4'-dimethoxyphenyl)propene. PubMed: Veratryl alcohol-mediated oxidation of isoeugenyl acetate by lignin peroxidase. PubMed: Oxidative polymerization of ribonuclease A by lignin peroxidase from Phanerochaete chrysosporium. Role of veratryl alcohol in polymer oxidation. PubMed: A search for ligninolytic peroxidases in the fungus pleurotus eryngii involving alpha-keto-gamma-thiomethylbutyric acid and lignin model dimers PubMed: Nitration of veratryl alcohol by lignin peroxidase and tetranitromethane. PubMed: Electrochemical analysis of the interactions of laccase mediators with lignin model compounds. PubMed: The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides. PubMed: Irreversible oxidation of ferricytochrome c by lignin peroxidase. PubMed: Interference of peptone and tyrosine with the lignin peroxidase assay. PubMed: Stimulation of aryl metabolite production in the basidiomycete Bjerkandera sp. strain BOS55 with biosynthetic precursors and lignin degradation products. PubMed: Tyrosinase-catalyzed oxidation of 3,4-dihydroxyphenylglycine. PubMed: Oxidation of dimethoxylated aromatic compounds by lignin peroxidase from Phanerochaete chrysosporium. PubMed: Enantioselective synthesis of 6-[fluorine-18]-fluoro-L-dopa from no-carrier-added fluorine-18-fluoride. PubMed: Anisaldehyde and Veratraldehyde Acting as Redox Cycling Agents for H(2)O(2) Production by Pleurotus eryngii. PubMed: Participation of Mn(II) in the catalysis of laccase, manganese peroxidase and lignin peroxidase from Phelbia radiata. PubMed: BE-23372M, a novel protein tyrosine kinase inhibitor. III. Synthesis. PubMed: Lignin peroxidase L3 from Phlebia radiata. Pre-steady-state and steady-state studies with veratryl alcohol and a non-phenolic lignin model compound 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol. PubMed: A new assay for lignin-type peroxidases employing the dye azure B. PubMed: De-novo biosynthesis of chlorinated aromatics by the white-rot fungus Bjerkandera sp. BOS55. Formation of 3-chloro-anisaldehyde from glucose. PubMed: Degradation of non-phenolic beta-o-4 lignin substructure model compounds by Acinetobacter sp. PubMed: Purification and properties of an aryl-alcohol dehydrogenase from the white-rot fungus Phanerochaete chrysosporium. PubMed: Purification and characterization of a veratryl alcohol oxidase enzyme from the lignin degrading basidiomycete Pleurotus ostreatus. PubMed: Degradation of labelled lignins and veratrylglycerol-beta-guaiacyl ether by Acinetobacter sp. PubMed: Effect of Mn(II) on reactions catalyzed by lignin peroxidase from Phanerochaete chrysosporium. PubMed: Oxidation of non-phenolic substrates. An expanded role for laccase in lignin biodegradation. PubMed: Glyoxal oxidase of Phanerochaete chrysosporium: its characterization and activation by lignin peroxidase. PubMed: Thiol-mediated oxidation of nonphenolic lignin model compounds by manganese peroxidase of Phanerochaete chrysosporium. PubMed: Studies on antifungal agents: aromatic acid hydrazones of o. vanillin, o. veratraldehyde, 5-bromo-o. vanillin and bourbonal. PubMed: On the reactions of lignin peroxidase compound III (isozyme H8). PubMed: Biomimetic oxidation of nonphenolic lignin models by Mn(III): new observations on the oxidizability of guaiacyl and syringyl substructures. PubMed: Selection and improvement of lignin-degrading microorganisms: potential strategy based on lignin model-amino Acid adducts. PubMed: Enzymatic determination of veratryl alcohol. PubMed: Analogues of poison ivy urushiol. Synthesis and biological activity of disubstituted n-alkylbenzenes. PubMed: Steady-state and transient-state kinetic studies on the oxidation of 3,4-dimethoxybenzyl alcohol catalyzed by the ligninase of Phanerocheate chrysosporium Burds. PubMed: Mechanism of oxidative C alpha-C beta cleavage of a lignin model dimer by Phanerochaete chrysosporium ligninase. Stoichiometry and involvement of free radicals. PubMed: [Microbial degradation of papaverine (author's transl)]. PubMed: Synthesis of some newer formazans and tetrazolium salts as antiviral agents. PubMed: Synthesis of certain 3-aminoquinazolinone Schiff's bases structurally related to some biologically active compounds. PubMed: Simultaneous determination of phenylbutazone and oxyphenbutazone in plasma by high-speed liquid chromatography. PubMed: [Metabolism of 3,4-dimethoxybenzaldehyde and 3,4-dimethoxybenzoic acid in perfused rat liver (author's transl)]. PubMed: [Studies on the syntheses of heterocyclic compounds. CCCXI. The formation of diveratryl ether in crossed cannizzaro reaction of veratraldehyde and trial of its cyclization]. PubMed: [The effects of benzaldehyde, anisaldehyde and veratraldehyde on the isolated ventricle of Helix aspersa]. PubMed: Azlactones and phenylacetic acids derived from the 2-nitro-derivatives of vanillin, isovanillin, and veratraldehyde. PubMed: Halogenated derivatives of methyleugenol; 6-bromomethyleugenol glycol and 6-bromohomover atraldehyde. PubMed: Studies in detoxication; the metabolism of veratraldehyde and veratric acid in the rabbit. PubMed: Studies in detoxication: 14. The metabolism of veratraldehyde and veratric acid in the rabbit.