Identification

Nameperillyl acetate
IUPAC(4-prop-1-en-2-yl-1-cyclohexenyl)methyl acetate
CAS Number15111-96-3
EINECS239-162-4
FDA UNII7P95D01XYJ
Molecular FormulaC12 H18 O
Molecular Weight178.27466000
Nikkaji NumberJ241.400G
CoE Number10742

Regulatory

JECFA Food Flavoring975 p-mentha-1,8-dien-7-yl acetate
DG SANTE Food Flavourings09.278 p-mentha-1,8-dien-7-yl acetate
FEMA Number3561
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)15111-96-3 ; PERILLYL ACETATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to orange yellow clear liquid (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.97200 to 0.98000 @ 25.00 °C.
Pounds per Gallon - (est). 8.088 to 8.155
Refractive Index 1.47600 to 1.48700 @ 20.00 °C.
Optical Rotation -71.00 to -79.00
Boiling Point 218.00 to 223.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.014000 mmHg @ 25.00 °C. (est)
Flash Point 200.00 °F. TCC ( 93.33 °C. )
logP (o/w) 3.610 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength medium
Substantivity 143 hour(s) at 100.00 %
Odor Description at 100.00 %.
Odor sample from CA Aromatics Company Inc.
Taste Description green geranium phenolic fruity herbal berry floral tropical

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for perillyl acetate usage levels up to2.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)1.40 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.07 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)1300 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)5.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)-
Edible ices, including sherbet and sorbet (03.0)5.00000
Processed fruit (04.1)-
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)5.00000
Chewing gum (05.3)0.10000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)7.20000
Meat and meat products, including poultry and game (08.0)1.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)-
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)-
Foodstuffs intended for particular nutritional uses (13.0)-
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.50000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)0.50000
Ready-to-eat savouries (15.0)-
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)2.00000

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Synerzine, Inc.

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Potential Uses

FR herbal FR oriental FR spice

Natural Occurrence

bergamot plant wild grapefruit peel oil lime oil expressed florida @ trace% Data mandarin fruit mikan peel oil @ 0.01% Data perilla frutescens var. acuta kudo oil pistacia vera resin pummelo peel oil sunflower flower wormwood oil cuba @ 0.20% Data

Synonyms

acetic acid perillyl ester 1- cyclohexene-1-methanol, 4-(1-methylethenyl)-, acetate dihydro cuminyl acetate dihydrocuminyl acetate p- mentha-1,8-dien-7-ol, acetate p- mentha-1,8-dien-7-yl acetate para- mentha-1,8-dien-7-yl acetate menthadien-7-carbinyl acetate 1,8-p- menthadien-7-yl acetate 1,8-para- menthadien-7-yl acetate 4- methyl vinyl cyclohexene-1-methyl acetate 4-(1- methyl vinyl) cyclohex-1-ene-1-methyl acetate 4-(1- methylethenyl)-1-cyclohexene-1-methyl acetate 4-(1- methylvinyl)cyclohex-1-ene-1-methyl acetate perilla acetate perillyl acetate (4- prop-1-en-2-yl-1-cyclohexenyl)methyl acetate [4-( prop-1-en-2-yl)cyclohex-1-en-1-yl]methyl acetate (4-iso propenyl-1-cyclohexen-1-yl)methyl acetate 4-iso propenyl-1-cyclohexene carbinol acetate PubMed: Coupling limonene formation and oxyfunctionalization by mixed-culture resting cell fermentation. PubMed: Improved antioxidant activity in transgenic Perilla frutescens plants via overexpression of the γ-tocopherol methyltransferase (γ-tmt) gene. PubMed: Medicinal plants from the genus Acalypha (Euphorbiaceae)--a review of their ethnopharmacology and phytochemistry. PubMed: A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes. PubMed: The oxygen-independent metabolism of cyclic monoterpenes in Castellaniella defragrans 65Phen. PubMed: Anti-inflammatory and antipruritic effects of luteolin from Perilla (P. frutescens L.) leaves. PubMed: Rosmarinic acid extract for antioxidant, antiallergic, and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves. PubMed: Rapid identification of aldose reductase inhibitory compounds from Perilla frutescens. PubMed: Structural characterization of phenolic antioxidants from purple perilla (Perilla frutescens var. acuta) leaves. PubMed: Skin repair properties of d-Limonene and perillyl alcohol in murine models. PubMed: Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo. PubMed: A QuEChERS-based extraction method for the residual analysis of pyraclofos and tebufenpyrad in perilla leaves using gas chromatography: application to dissipation pattern. PubMed: In vitro biological activities of the essential oil from the 'resurrection plant' Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar. PubMed: Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans. PubMed: Optimization of antibacterial activity of Perilla frutescens var. acuta leaf against Staphylococcus aureus using evolutionary operation factorial design technique. PubMed: Volatile oil profiles of the aerial parts of Jordanian garland, Chrysanthemum coronarium. PubMed: Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis. PubMed: Gateways to clinical trials. PubMed: A fluorometric assay to determine antioxidant activity of both hydrophilic and lipophilic components in plant foods. PubMed: [Determination of difenoconazole residue in foods by gas chromatography-negative chemical ionization mass spectrometry]. PubMed: Evaluation of characteristic aroma compounds of Citrus natsudaidai Hayata (Natsudaidai) cold-pressed peel oil. PubMed: Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor. PubMed: Volatile constituents of redblush grapefruit (Citrus paradisi) and pummelo (Citrus grandis) peel essential oils from Kenya. PubMed: Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages. PubMed: Gateways to clinical trials. PubMed: Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism. PubMed: Gateways to clinical trials. PubMed: Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. PubMed: Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. PubMed: Gateways to clinical trials. PubMed: Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion. PubMed: Differences in the fragrances of pollen, leaves, and floral parts of garland (Chrysanthemum coronarium) and composition of the essential oils from flowerheads and leaves. PubMed: Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. PubMed: Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. PubMed: Anti-inflammatory and anti-allergic actions by oral administration of a perilla leaf extract in mice. PubMed: Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. PubMed: Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells. PubMed: Inhibition of tumor necrosis factor-alpha production by orally administering a perilla leaf extract. PubMed: Analysis of perillic acid in plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection. PubMed: Benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II from Acinetobacter calcoaceticus. Substrate specificities and inhibition studies.