hexyl salicylate

salicylic acid, hexyl ester

CAS: 6259-76-3 C13 H18 O3 MW: 222.28406000 herbal herbal

Identification

Namehexyl salicylate
IUPAChexyl 2-hydroxybenzoate
CAS Number6259-76-3
EINECS228-408-6
FDA UNII8F78EY72YL
Molecular FormulaC13 H18 O3
Molecular Weight222.28406000
MDL NumberMFCD00036487
Nikkaji NumberJ169.182A
Beilstein2453103
CoE Number10695
XlogP35.70 (est)

Regulatory

DG SANTE Food Flavourings09.581 hexyl salicylate

Physical Properties

Appearance colorless clear oily liquid (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.03300 to 1.04100 @ 20.00 °C.
Pounds per Gallon - est. 8.606 to 8.672
Boiling Point 290.00 °C. @ 760.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.000491 mmHg @ 25.00 °C. (est)
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 5.070 (est)
Soluble in alcohol
Insoluble in water
Stability alcoholic lotion
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength low
Substantivity 40 hour(s) at 100.00 %
Odor Description
at 100.00 %.
A dry haylike waxy floral odor
pleasant natural, floral-spicy (azalea, clove, remote ylang ylang), tangy, fresh-green
Floral, Green, Fruity
sweet, aromatic, floral, spicy, medicinal
Sweet aromatic floral medicinal Witch-Hazel-odor Jasmin Orchid
SWEET-HERBACEOUS AND FLORAL
Mild, balsamic, fresh, herbal, floral, typical salicylate character, good blending agent.
Odor sample from Aceto Corporation
Taste Description
herbal green metallic floral algae tomato leaf asparagus
dry, hay note, waxy, floral

Safety Information

European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 > 5000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
IFRA Critical EffectDermal sensitization and systemic toxicity
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%)Category 1: Products applied to the lips
NotesIFRA FLAVOR REQUIREMENTS:
use level in formulae for use in cosmetics4.3473 %
Dermal Systemic Exposure in Cosmetic Products0.11 mg/kg/day (IFRA, 2002)
Maximised Survey-derived Daily Intakes (MSDI-EU)0.018 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)3900 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
Dairy products, excluding products of category 02.0 (01.0)7.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)5.00000
Edible ices, including sherbet and sorbet (03.0)10.00000
Processed fruit (04.1)7.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)10.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)10.00000
Meat and meat products, including poultry and game (08.0)2.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)2.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)5.00000
Foodstuffs intended for particular nutritional uses (13.0)10.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)5.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)10.00000
Ready-to-eat savouries (15.0)20.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)5.00000

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Potential Uses

FR aldehydic FR almond FR alpine bouquet FR amber FR apple blossom FR apricot FR azalea FR balsam FR banana FR blue grass FR blue mist FR bouquet FR camellia FR carnation FR cedar FR cherry FR cherry blossom FR christmas FR chrysanthemum FR chypre FR citrus FR clove FR clover FR coconut tropical coconut FR country meadow FR currant FR cyclamen FR fern FR floral FR fresh outdoors FR fruit FR genet FR gooseberry FR green FL grenadine FR hay new mown hay FR herbal FR honey FR hyacinth FR labdanum FR leather FR lemon FR lilac FR lotus FR mimosa FR mint FR moss FR musk FR orange FR orchid FR oriental FR peach FR pine FR plum FR poppy red poppy FR potpourri FR raspberry FR rose FR rose tea rose rounding off FR sea breeze solvents FR spearmint FR spice FR strawberry FR tuberose FR vanilla FR wallflower FR woody FR ylang ylang

Natural Occurrence

osmanthus absolute @ 0.007% Data

Synonyms

benzoic acid, 2-hydroxy-, hexyl ester hexyl 2-hydroxy-1-benzene carboxylate hexyl 2-hydroxybenzoate hexyl o-hydroxybenzoate hexyl ortho-hydroxybenzoate 1- hexyl salicylate N- hexyl salicylate hexyl-2-hydroxybenzoate N- hexyl-o-hydroxybenzoate hexylsalicylate 2- hydroxybenzoic acid hexyl ester rhodiaflor SnH salicylic acid hexyl ester salicylic acid, hexyl ester PubMed: Determination of the shell permeability of microcapsules with a core of oil-based active ingredient. PubMed: Fragrance material review on ethyl hexyl salicylate. PubMed: Fragrance material review on hexyl salicylate. PubMed: Effective and efficient photoluminescence of salicylate-ligating terbium(III) clusters stabilized by multiple phenyl-phenyl interactions. PubMed: Fragrance contact dermatitis - a worldwide multicenter investigation (Part III). PubMed: Comparison of models of odor interaction.