Identification

Namechocolate extract

Regulatory

Physical Properties

Food Chemicals Codex Listed No

Organoleptic Properties

Taste Description chocolate

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavored products of all types
Recommendation for chocolate extract usage levels up tonot for fragrance use.

Advanced Biotech. Inc.

Inspired by Nature

A diverse range of products, all meeting our stringent commitment to quality.

View All Website 973-339-6242 info@adv-bio.com

Horner International

The finest extracts in the world

Horner International supplies the finest natural extracts and flavors to a world-wide customer base.

View All Website +1 919 787 3112 ext. 112 lisa.ramraj@hornerintl.com

FRUTAROM USA INC,

Flavor & Specialty Ingredients

Your preferred partner for flavour and fragrance success.

View All Website +44 (0) 1429 863 222 Sales.IFFIngredients@iff.com

Potential Uses

None Found

Natural Occurrence

natural

Synonyms

chocolate fluid extract chocolate spray-dried powder extract PubMed: Cocoa phenolic extract protects pancreatic beta cells against oxidative stress. PubMed: Rapid differentiation of Ghana cocoa beans by FT-NIR spectroscopy coupled with multivariate classification. PubMed: Cocoa powder extracts exhibits hypolipidemic potential in cholesterol-fed rats. PubMed: Active films based on cocoa extract with antioxidant, antimicrobial and biological applications. PubMed: Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway. PubMed: Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells. PubMed: Cocoa husks in diets of Italian heavy pigs. PubMed: Reducing effect of an extract of Phaseolus vulgaris on food intake in mice--focus on highly palatable foods. PubMed: [Investigation of bacterial etiology with conventional and multiplex PCR methods in adult patients with community-acquired pneumonia]. PubMed: Cocoa polyphenols prevent inflammation in the colon of azoxymethane-treated rats and in TNF-α-stimulated Caco-2 cells. PubMed: Human bioavailability of flavanols and phenolic acids from cocoa-nut creams enriched with free or microencapsulated cocoa polyphenols. PubMed: Cocoa polyphenols are absorbed in Caco-2 cell model of intestinal epithelium. PubMed: Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on operant self-administration of a chocolate-flavoured beverage in rats. PubMed: Distribution of procyanidins and their metabolites in rat plasma and tissues in relation to ingestion of procyanidin-enriched or procyanidin-rich cocoa creams. PubMed: Preventing Ralstonia solanacearum adhesion with glycans from cashew, cocoa, coffee, pumpkin, and tomato seed extract. PubMed: Method for the determination of catechin and epicatechin enantiomers in cocoa-based ingredients and products by high-performance liquid chromatography: single-laboratory validation. PubMed: Cocoa polyphenols suppress adipogenesis in vitro and obesity in vivo by targeting insulin receptor. PubMed: Modification of ginseng flavors by bitter compounds found in chocolate and coffee. PubMed: Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats. PubMed: Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice. PubMed: Selective removal of the violet color produced by anthocyanins in procyanidin-rich unfermented cocoa extracts. PubMed: Consumer acceptance of ginseng food products. PubMed: Nutrient agar with sodium chloride supplementation for presumptive detection of Moraxella catarrhalis in clinical specimens. PubMed: In vitro activity of extract and fractions of natural cocoa powder on Plasmodium falciparum. PubMed: A polyphenol-enriched cocoa extract reduces free radicals produced by mycotoxins. PubMed: Screening for natural chemoprevention agents that modify human Keap1. PubMed: Effect of a cocoa polyphenol extract in spontaneously hypertensive rats. PubMed: Comparative evaluation of chlorhexidine mouthrinse versus cacao bean husk extract mouthrinse as antimicrobial agents in children. PubMed: Development of an immuno-affinity column for ochratoxin analysis using an organic solvent-tolerant monoclonal antibody. PubMed: Inhibitory activity of Asian spices on heterocyclic amines formation in cooked beef patties. PubMed: One-PCR-tube approach for in situ DNA isolation and detection. PubMed: CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract. PubMed: A new glycosylated dihydrophaseic acid from cacao germs (Theobroma cacao L.). PubMed: Botrytone, a new naphthalenone pentaketide produced by Botrytis fabae, the causal agent of chocolate spot disease on Vicia faba. PubMed: A comprehensive evaluation of the toxicology of cigarette ingredients: cocoa-derived ingredients. PubMed: Determination of the cyanobacterial toxin cylindrospermopsin in algal food supplements. PubMed: Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells. PubMed: Human basophils: a unique biological instrument to detect the allergenicity of food. PubMed: Inhibition of key digestive enzymes by cocoa extracts and procyanidins. PubMed: On the taste of "Bouba" and "Kiki": An exploration of word-food associations in neurologically normal participants. PubMed: Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. PubMed: Determination of roasted pistachio (Pistacia vera L.) key odorants by headspace solid-phase microextraction and gas chromatography-olfactometry. PubMed: A new arginase enzymatic reactor: development and application for the research of plant-derived inhibitors. PubMed: Cacao seeds are a "Super Fruit": A comparative analysis of various fruit powders and products. PubMed: Effects of cocoa extract and dark chocolate on angiotensin-converting enzyme and nitric oxide in human endothelial cells and healthy volunteers--a nutrigenomics perspective. PubMed: The effect of nutrition on blood pressure. PubMed: Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells. PubMed: Physical properties and bioactive constituents of powdered mixtures and drinks prepared with cocoa and various sweeteners. PubMed: Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity. PubMed: Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats. PubMed: Acute Treatment With Herbal Extracts Provides Neuroprotective Benefits in In Vitro and In Vivo Stroke Models, Characterized by Reduced Ischemic Cell Death and Maintenance of Motor and Neurological Functions. PubMed: Development and validation of an indirect competitive enzyme linked-immunosorbent assay for the determination of potentially allergenic sesame (Sesamum indicum) in food. PubMed: Protective activity of Theobroma cacao L. phenolic extract on AML12 and MLP29 liver cells by preventing apoptosis and inducing autophagy. PubMed: Towards a platform for the metabonomic profiling of different strains of Drosophila melanogaster using liquid chromatography-Fourier transform mass spectrometry. PubMed: Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats. PubMed: Dark chocolate or tomato extract for prehypertension: a randomised controlled trial. PubMed: Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells? PubMed: Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells. PubMed: Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites. PubMed: Single-drop micro-extraction and diffuse reflectance Fourier transform infrared spectroscopic determination of chromium in biological fluids. PubMed: Crude cacao Theobroma cacao extract reduces mutagenicity induced by benzo[a]pyrene through inhibition of CYP1A activity in vitro. PubMed: Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress. PubMed: Simultaneous determination of theobromine, (+)-catechin, caffeine, and (-)-epicatechin in standard reference material baking chocolate 2384, cocoa, cocoa beans, and cocoa butter. PubMed: Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats. PubMed: Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice. PubMed: Grape seed procyanidins inhibit the expression of metallothione in genes in human HepG2 cells. PubMed: Cocoa polyphenols and their influence on parameters involved in ex vivo skin restructuring. PubMed: Obtention and characterization of phenolic extracts from different cocoa sources. PubMed: Acetobacter fabarum sp. nov., an acetic acid bacterium from a Ghanaian cocoa bean heap fermentation. PubMed: Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats. PubMed: In vitro stability, potency, and dissolution of duloxetine enteric-coated pellets after exposure to applesauce, apple juice, and chocolate pudding. PubMed: Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract. PubMed: Chocolate mouth rinse: Effect on plaque accumulation and mutans streptococci counts when used by children. PubMed: [Investigation of ochratoxin a, B and citrinin contamination in various commercial foods]. PubMed: Use of response surface methodology to examine chitinase regulation in the basidiomycete Moniliophthora perniciosa. PubMed: Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats. PubMed: Cacao procyanidins reduce plasma cholesterol and increase fecal steroid excretion in rats fed a high-cholesterol diet. PubMed: Therapeutic effect of ACTICOA powder, a cocoa polyphenolic extract, on experimentally induced prostate hyperplasia in Wistar-Unilever rats. PubMed: Preventive effects of ACTICOA powder, a cocoa polyphenolic extract, on experimentally induced prostate hyperplasia in Wistar-Unilever rats. PubMed: Protective effect of Acticoa powder, a cocoa polyphenolic extract, on prostate carcinogenesis in Wistar-Unilever rats. PubMed: Repression of calcitonin gene-related peptide expression in trigeminal neurons by a Theobroma cacao extract. PubMed: Preventive antioxidant effects of cocoa polyphenolic extract on free radical production and cognitive performances after heat exposure in Wistar rats. PubMed: The antibacterial activity of plant extracts containing polyphenols against Streptococcus mutans. PubMed: Acetobacter ghanensis sp. nov., a novel acetic acid bacterium isolated from traditional heap fermentations of Ghanaian cocoa beans. PubMed: Standard reference materials for foods and dietary supplements. PubMed: In vitro evaluation of alternative oral contrast agents for MRI of the gastrointestinal tract. PubMed: Quantification of flavor-related compounds in the unburned contents of bidi and clove cigarettes. PubMed: [Characterization of cocoa fiber and its effect on the antioxidant capacity of serum in rats]. PubMed: Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. PubMed: Characterization of aroma-active compounds in raw and cooked pine-mushrooms (Tricholoma matsutake Sing.). PubMed: Identification of the key aroma compounds in cocoa powder based on molecular sensory correlations. PubMed: In-vitro effects of polyphenols from cocoa and beta-sitosterol on the growth of human prostate cancer and normal cells. PubMed: Analysis of acrylamide in coffee and cocoa by isotope dilution liquid chromatography-tandem mass spectrometry. PubMed: Determination of acrylamide in various food matrices: evaluation of LC and GC mass spectrometric methods. PubMed: Determination of biogenic amines in chocolate by ion chromatographic separation and pulsed integrated amperometric detection with implemented wave-form at Au disposable electrode. PubMed: Flavonoids from Theobroma cacao down-regulate inflammatory mediators. PubMed: Polyphenol levels in human urine after intake of six different polyphenol-rich beverages. PubMed: Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia. PubMed: Quantitation of acrylamide in food products by liquid chromatography/mass spectrometry. PubMed: Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao). PubMed: Effect of Theobroma cacao flavonoids on immune activation of a lymphoid cell line. PubMed: Curare: the South American arrow poison. PubMed: The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats. PubMed: Bacteremia in a patient with colonic carcinoma caused by a novel Sedimentibacter species: Sedimentibacter hongkongensis sp. nov. PubMed: Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells. PubMed: Inhibitory effects of cacao bean husk extract on plaque formation in vitro and in vivo. PubMed: Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats. PubMed: Determination of ephedrine alkaloids in botanicals and dietary supplements by HPLC-UV: collaborative study. PubMed: Anti-cariogenic properties of a water-soluble extract from cacao. PubMed: Effect of the number of flavanol units on the antioxidant activity of procyanidin fractions isolated from chocolate. PubMed: The effect of herbal remedy on the development of Trichinella spiralis infection in mice. PubMed: Benzophenone in cartonboard packaging materials and the factors that influence its migration into food. PubMed: Immunochemical-based method for detection of hazelnut proteins in processed foods. PubMed: Effects of an aqueous extract of cocoa on nitric oxide production of macrophages activated by lipopolysaccharide and interferon-gamma. PubMed: Determination of retinyl palmitate (vitamin A) in fortified fluid milk by liquid chromatography: collaborative study. PubMed: The impact of fortification with conjugated linoleic acid (CLA) on the quality of fluid milk. PubMed: [Determination of sucralose in foods by liquid chromatography/tandem mass spectrometry]. PubMed: Lack of in vivo clastogenic activity of grape seed and grape skin extracts in a mouse micronucleus assay. PubMed: Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans. PubMed: Subchronic 3-month oral toxicity study of grape seed and grape skin extracts. PubMed: Cocoa extract protects against early alcohol-induced liver injury in the rat. PubMed: Chemical evaluation and digestibility of cocoa (Theobroma cacao) byproducts fed to goats. PubMed: Inhibitory effects of cocoa flavanols and procyanidin oligomers on free radical-induced erythrocyte hemolysis. PubMed: Use of gas chromatography-olfactometry to identify key odorant compounds in dark chocolate. Comparison of samples before and after conching. PubMed: Serum IgG response to differentiated antigens of Helicobacter pylori. PubMed: Standardization of broth microdilution and disk diffusion susceptibility tests for Actinobacillus pleuropneumoniae and Haemophilus somnus: quality control standards for ceftiofur, enrofloxacin, florfenicol, gentamicin, penicillin, tetracycline, tilmicosin, and trimethoprim-sulfamethoxazole. PubMed: Anticlastogenic activity of cacao: inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage. PubMed: Aroma components of cooked tail meat of American lobster (Homarus americanus). PubMed: Improved high-performance liquid chromatography method to determine theobromine and caffeine in cocoa and cocoa products. PubMed: [Determination of bisphenol A in foods using GC/MS]. PubMed: Diverse biological activity of polycaphenol. PubMed: Determination of conjugated linoleic acid (CLA) concentrations in milk chocolate. PubMed: Development of antirotavirus agents in Asia. PubMed: Cariostatic activity of cacao mass extract. PubMed: Caries inhibitory activity of cacao bean husk extract in in-vitro and animal experiments. PubMed: Determination of inulin in foods. PubMed: [Antibacterial effects of cacao mass on enterohemorrhagic Escherichia coli O157:H7]. PubMed: Resistance profile survey of 50 periodontal strains of Actinobacillus actinomyectomcomitans. PubMed: Pharmacologic effects of cocoa and rye flour extracts on isolated guinea pig trachea. PubMed: Nutritive value of hot water- or cocoa-pod ash solution-treated cocoa bean cake for broiler chicks. PubMed: Respiratory function and immunological status in cocoa and flour processing workers. PubMed: Comparison of axenic and monoxenic media for isolation of Acanthamoeba. PubMed: Helicobacter pylori--in vitro susceptibility to garlic (Allium sativum) extract. PubMed: Evaluation of an extended blood culture protocol to isolate fastidious organisms from patients with AIDS. PubMed: Nutrient and antinutrient profiles of raw and fermented cocoa beans. PubMed: Theobromine toxicity on Sertoli cells and comparison with cocoa extract in male rats. PubMed: Agar disk diffusion (Bauer-Kirby) tests with various fastidious and nonfastidious reference (ATCC) strains: comparison of several agar media. PubMed: Determination of aspartame and its major decomposition products in foods. PubMed: Determination of acesulfam-K in foods. PubMed: Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum. PubMed: Triacetin as food additive in gummy candy and other foodstuffs on the market. PubMed: Reproductive toxicity of theobromine and cocoa extract in male rats. PubMed: Effect of cacao husk extract on human immunodeficiency virus infection. PubMed: Egg yolk emulsion agar, a new medium for the cultivation of Helicobacter pylori. PubMed: A newly recognized fastidious gram-negative pathogen as a cause of fever and bacteremia. PubMed: Effects of long-term laxative treatment on rat mesenteric resistance vessel responses in vitro. PubMed: Inhibitory effects of aqueous extract of cacao bean husk on collagenase of Bacteroides gingivalis. PubMed: [Haemophilus somnus as a cause of bronchopneumonia in calves]. PubMed: Improved medium for antimicrobial susceptibility testing of Haemophilus influenzae. PubMed: Studies on the estrogenic activity of a coffee extract. PubMed: Pseudomonas mesophilica infections in humans. PubMed: [Acute recurring Quincke edema in allergy to malt extract]. PubMed: [Effect of the harvest season on the composition of raw and fermented cotyledons of 2 varieties of cacao and shell fractions]. PubMed: Extraction procedures for oilseeds and related high fat-low moisture products. PubMed: [Isolation of the Derivatives from Coca-Powder Fumigated by Ethylene Oxide 1,2-14 C and their Structure Suggested on the Basis of I. R. and Mass-Spectrometry]. PubMed: [Group separation of ethylene oxide 1,2-14c fumigated coca-powder derivatives and their distribution of radioactivity (author's transl)]. PubMed: Diets for Rearing the Ambrosia Beetle Xyleborus ferrugineus (Fabricius) in vitro. PubMed: Effect on hamster caries by dialysed, detanned or carbon-treated water-extract of cocoa. PubMed: [A discussion contribution to spectrophotometric differentiation of cocoa pressed butter and cocoa fat extract].