homomenthyl salicylate

benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester

CAS: 118-56-9 C16 H22 O3 MW: 262.34894000

Identification

Namehomomenthyl salicylate
CAS Number118-56-9
EINECS204-260-8
FDA UNIIV06SV4M95S
Molecular FormulaC16 H22 O3
Molecular Weight262.34894000
MDL NumberMFCD00019377
Nikkaji NumberJ5.301E
Beilstein2731604

Regulatory

Physical Properties

Appearance colorless to pale yellow clear viscous liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.04800 to 1.05200 @ 25.00 °C.
Pounds per Gallon - (est). 8.720 to 8.754
Refractive Index 1.51600 to 1.51900 @ 20.00 °C.
Boiling Point 161.00 to 164.00 °C. @ 4.00 mm Hg
Vapor Pressure 0.000041 mmHg @ 25.00 °C. (est)
Flash Point 308.00 °F. TCC ( 153.33 °C. )
logP (o/w) 5.947 (est)
Soluble in alcohol
Insoluble in water
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Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

Organoleptic Properties

Odor Strength low
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 36500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants and stabilizers
Recommendation for homomenthyl salicylate usage levels up tonot for fragrance use.
Recommendation for homomenthyl salicylate flavor usage levels up tonot for flavor use.

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Potential Uses

skin conditioning u.v. absorbers u.v. filters

Natural Occurrence

not found in nature

Synonyms

benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester component of coppertone coppertone eusolex filtrosol A heliopan heliophan homosalate 2- hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester homo menthyl salicylate USP neo heliopan HMS (Symrise) salicylic acid 3,3,5-trimethylcyclohexyl ester salicylic acid, 3,3,5-trimethylcyclohexyl ester salicylic acid, m-homomenthyl ester 3,3,5- trimethylcyclohexyl 2-hydroxybenzoate 3,3,5- trimethylcyclohexyl salicylate (3,3,5- trimethylcyclohexyl) 2-hydroxybenzoate YOS H PubMed: Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats. PubMed: Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. PubMed: Lichenic extracts and metabolites as UV filters. PubMed: UV filters, ingredients with a recognized anti-inflammatory effect. PubMed: Determination of ultraviolet filters in environmental water samples by temperature-controlled ionic liquid dispersive liquid-phase microextraction. PubMed: Ionic liquid-based ultrasound-assisted dispersive liquid-liquid microextraction followed high-performance liquid chromatography for the determination of ultraviolet filters in environmental water samples. PubMed: Simultaneous determination of ultraviolet filters in aqueous samples by plunger-in-needle solid-phase microextraction with graphene-based sol-gel coating as sorbent coupled with gas chromatography-mass spectrometry. PubMed: Determination of ultraviolet filters in water samples by vortex-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. PubMed: An overview of UV-absorbing compounds (organic UV filters) in aquatic biota. PubMed: Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters. PubMed: Development and application of a HPLC method for eight sunscreen agents in suncare products. PubMed: Preparation, characterization and evaluation of sun protective and moisturizing effects of nanoliposomes containing safranal. PubMed: Fast liquid chromatography-diode array detection assisted by chemometrics for quantification of seven ultraviolet filters in effluent wastewater. PubMed: Occurrence and profiles of organic sun-blocking agents in surface waters and sediments in Japanese rivers and lakes. PubMed: Simultaneous determination of some ultraviolet-absorbing chemicals in sunscreen cosmetics using a high-performance liquid chromatography method. PubMed: On-line renewable solid-phase extraction hyphenated to liquid chromatography for the determination of UV filters using bead injection and multisyringe-lab-on-valve approach. PubMed: Does saffron have antisolar and moisturizing effects? PubMed: Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry. PubMed: Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples. PubMed: Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry. PubMed: Quercetin and rutin as potential sunscreen agents: determination of efficacy by an in vitro method. PubMed: Dosage de l'octyl dimethyl PABA, de l'homosalate et de l'octyl salicylate dans les produits de protection solaire. PubMed: 3,3,5-Trimethylcyclohexanols and derived esters: green synthetic procedures, odour evaluation and in vitro skin cytotoxicity assays. PubMed: Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation. PubMed: Photoprotective activity of propolis. PubMed: Study of the efficacy of 18 sun filters authorized in European Union tested in vitro. PubMed: Determination of UV filters and antimicrobial agents in environmental water samples. PubMed: Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations. PubMed: Spectroscopic and photochemical properties of the lichen compound lobaric acid. PubMed: Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. PubMed: Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. PubMed: Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography. PubMed: Liquid chromatographic assay for common sunscreen agents: application to in vivo assessment of skin penetration and systemic absorption in human volunteers. PubMed: Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. PubMed: UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay. PubMed: Skin penetration and sun protection factor of five UV filters: effect of the vehicle. PubMed: Comments on "In vitro and in vivo estrogenicity of UV screens". PubMed: Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier. PubMed: Determination of UV-filters in sunscreens by HPLC. PubMed: In vitro and in vivo estrogenicity of UV screens. PubMed: A predictive mouse ear-swelling model for investigating topical photoallergy. PubMed: Contact photoallergy testing of sunscreens in guinea pigs. PubMed: Contact dermatitis to homomenthyl salicylate. PubMed: Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6. PubMed: Detection of pharmaceuticals and other personal care products in groundwater beneath and adjacent to onsite wastewater treatment systems in a coastal plain shallow aquifer.