10-hydroxydecenoic acid
2-decenoic acid, 10-hydroxy-
Identification
| Name | 10-hydroxydecenoic acid |
| IUPAC | 10-hydroxydec-2-enoic acid |
| CAS Number | 765-01-5 |
| FDA UNII | 76B519G7TJ |
| Molecular Formula | C10 H18 O3 |
| Molecular Weight | 186.25106000 |
| MDL Number | MFCD00204506 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 339.00 to 340.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 344.00 °F. TCC ( 173.10 °C. ) (est) |
| logP (o/w) | 1.808 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for 10-hydroxydecenoic acid usage levels up to | not for fragrance use. |
| Recommendation for 10-hydroxydecenoic acid flavor usage levels up to | not for flavor use. |
BOC Sciences
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Jiangyin Healthway International Trade Co., Ltd
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Potential Uses
Natural Occurrence
Synonyms
2-
decenoic acid, 10-hydroxy-
10-
hydroxy-2-decenoic acid
10-
hydroxy-trans-2-decenoic acid
PubMed:
Geographical influences on content of 10-hydroxy-trans-2-decenoic acid in royal jelly in China.
PubMed:
Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages.
PubMed:
10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5'-AMP-activated protein kinase in L6 myotubes and mice.
PubMed:
Hypoallergenicity and immunological characterization of enzyme-treated royal jelly from Apis mellifera.
PubMed:
Oriental orchid (Cymbidium floribundum) attracts the Japanese honeybee (Apis cerana japonica) with a mixture of 3-hydroxyoctanoic acid and 10-hydroxy- (E)-2-decenoic acid.
PubMed:
Contribution of lipids in honeybee (Apis mellifera) royal jelly to health.
PubMed:
Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production.
PubMed:
Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses.
PubMed:
10-Hydroxy-2-decenoic acid prevents ultraviolet A-induced damage and matrix metalloproteinases expression in human dermal fibroblasts.
PubMed:
Hydroxy decenoic acid down regulates gtfB and gtfC expression and prevents Streptococcus mutans adherence to the cell surfaces.
PubMed:
Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression.
PubMed:
Effects of Hydroxydecine(®) (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis.
PubMed:
Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans.
PubMed:
Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis.
PubMed:
Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production.
PubMed:
Specific hydroxy fatty acids in royal jelly activate TRPA1.
PubMed:
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.
PubMed:
10-Hydroxy-2-decenoic acid from Royal jelly: a potential medicine for RA.
PubMed:
Drones of the dwarf honey bee Apis florea are attracted to (2E)-9-oxodecenoic acid and (2E)-10-hydroxydecenoic acid.
PubMed:
Comparison of bee products based on assays of antioxidant capacities.
PubMed:
10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells.
PubMed:
Estrogenic activities of Fatty acids and a sterol isolated from royal jelly.
PubMed:
Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro.
PubMed:
Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera).
PubMed:
Determination of (E)-10-hydroxy-2-decenoic acid content in pure royal jelly: a comparison between a new CZE method and HPLC.
PubMed:
Optimized determination method for trans-10-hydroxy-2-decenoic acid content in royal jelly by high-performance liquid chromatography with an internal standard.
PubMed:
Beyond 9-ODA: sex pheromone communication in the European honey bee Apis mellifera L.
PubMed:
Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera).
PubMed:
Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism.
PubMed:
[The research of 10-hydroxy-2-decenoic acid on experiment hyperlipoidemic rat].
PubMed:
[Determination of 10-HDA in honeybee body by HPLC].
PubMed:
Insight into some of the signaling pathways triggered by a lipid immunomodulator.
PubMed:
Antifatigue effect of fresh royal jelly in mice.
PubMed:
[Features of fatty acid composition of queen bee jelly].
PubMed:
[Determination of 10-hydroxy-2-decenoic acid (10-HDA) in Chinese traditional medicine preparations by high performance liquid chromatography].
PubMed:
Storage-dependent degradation of 57-kDa protein in royal jelly: a possible marker for freshness.
PubMed:
Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography.
PubMed:
Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro.
PubMed:
Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly.
PubMed:
[Effects of royal jelly and 10-hydroxy decenoic acid on the sebaceous glands of hamster ear].
PubMed:
[The physiological dispositions of 10-hydroxy-delta 2-decenoic acid (10-HDA) in rats and mice].
PubMed:
[Establishment of human glioma cell line--nude mice solid tumor model NHG-1 and its characteristics].
PubMed:
[Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography].
PubMed:
[Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography].
PubMed:
New synthesis of royal jelly acid.
PubMed:
Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly.
PubMed:
Biological origin and configuration of 10-hydroxy-2-decenoic acid.
PubMed:
Activity of 10-hydroxydecenoic acid from royal jelly against experimental leukaemia and ascitic tumours.