10-hydroxydecenoic acid

2-decenoic acid, 10-hydroxy-

CAS: 765-01-5 C10 H18 O3 MW: 186.25106000

Identification

Name10-hydroxydecenoic acid
IUPAC10-hydroxydec-2-enoic acid
CAS Number765-01-5
FDA UNII76B519G7TJ
Molecular FormulaC10 H18 O3
Molecular Weight186.25106000
MDL NumberMFCD00204506

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 339.00 to 340.00 °C. @ 760.00 mm Hg (est)
Flash Point 344.00 °F. TCC ( 173.10 °C. ) (est)
logP (o/w) 1.808 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for 10-hydroxydecenoic acid usage levels up tonot for fragrance use.
Recommendation for 10-hydroxydecenoic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

2- decenoic acid, 10-hydroxy- 10- hydroxy-2-decenoic acid 10- hydroxy-trans-2-decenoic acid PubMed: Geographical influences on content of 10-hydroxy-trans-2-decenoic acid in royal jelly in China. PubMed: Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages. PubMed: 10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5'-AMP-activated protein kinase in L6 myotubes and mice. PubMed: Hypoallergenicity and immunological characterization of enzyme-treated royal jelly from Apis mellifera. PubMed: Oriental orchid (Cymbidium floribundum) attracts the Japanese honeybee (Apis cerana japonica) with a mixture of 3-hydroxyoctanoic acid and 10-hydroxy- (E)-2-decenoic acid. PubMed: Contribution of lipids in honeybee (Apis mellifera) royal jelly to health. PubMed: Inhibitory mechanism of 10-hydroxy-trans-2-decenoic acid (royal jelly acid) against lipopolysaccharide- and interferon-β-induced nitric oxide production. PubMed: Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses. PubMed: 10-Hydroxy-2-decenoic acid prevents ultraviolet A-induced damage and matrix metalloproteinases expression in human dermal fibroblasts. PubMed: Hydroxy decenoic acid down regulates gtfB and gtfC expression and prevents Streptococcus mutans adherence to the cell surfaces. PubMed: Inhibitory effect of 10-hydroxy-trans-2-decenoic acid on LPS-induced IL-6 production via reducing IκB-ζ expression. PubMed: Effects of Hydroxydecine(®) (10-hydroxy-2-decenoic acid) on skin barrier structure and function in vitro and clinical efficacy in the treatment of UV-induced xerosis. PubMed: Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PubMed: Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. PubMed: Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production. PubMed: Specific hydroxy fatty acids in royal jelly activate TRPA1. PubMed: Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. PubMed: 10-Hydroxy-2-decenoic acid from Royal jelly: a potential medicine for RA. PubMed: Drones of the dwarf honey bee Apis florea are attracted to (2E)-9-oxodecenoic acid and (2E)-10-hydroxydecenoic acid. PubMed: Comparison of bee products based on assays of antioxidant capacities. PubMed: 10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. PubMed: Estrogenic activities of Fatty acids and a sterol isolated from royal jelly. PubMed: Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. PubMed: Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). PubMed: Determination of (E)-10-hydroxy-2-decenoic acid content in pure royal jelly: a comparison between a new CZE method and HPLC. PubMed: Optimized determination method for trans-10-hydroxy-2-decenoic acid content in royal jelly by high-performance liquid chromatography with an internal standard. PubMed: Beyond 9-ODA: sex pheromone communication in the European honey bee Apis mellifera L. PubMed: Isolation and characterization of some hydroxy fatty and phosphoric acid esters of 10-hydroxy-2-decenoic acid from the royal jelly of honeybees (Apis mellifera). PubMed: Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. PubMed: [The research of 10-hydroxy-2-decenoic acid on experiment hyperlipoidemic rat]. PubMed: [Determination of 10-HDA in honeybee body by HPLC]. PubMed: Insight into some of the signaling pathways triggered by a lipid immunomodulator. PubMed: Antifatigue effect of fresh royal jelly in mice. PubMed: [Features of fatty acid composition of queen bee jelly]. PubMed: [Determination of 10-hydroxy-2-decenoic acid (10-HDA) in Chinese traditional medicine preparations by high performance liquid chromatography]. PubMed: Storage-dependent degradation of 57-kDa protein in royal jelly: a possible marker for freshness. PubMed: Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography. PubMed: Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro. PubMed: Liquid chromatographic determination of trans-10-hydroxy-2-decenoic acid content of commercial products containing royal jelly. PubMed: [Effects of royal jelly and 10-hydroxy decenoic acid on the sebaceous glands of hamster ear]. PubMed: [The physiological dispositions of 10-hydroxy-delta 2-decenoic acid (10-HDA) in rats and mice]. PubMed: [Establishment of human glioma cell line--nude mice solid tumor model NHG-1 and its characteristics]. PubMed: [Determination of 10-hydroxy-trans-2-decenoic acid (10-HDA) in royal jelly by gas liquid chromatography]. PubMed: [Determination of 10-hydroxy-2-decenoic acid in ginseng royal jelly by reversed phase high performance liquid chromatography]. PubMed: New synthesis of royal jelly acid. PubMed: Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly. PubMed: Biological origin and configuration of 10-hydroxy-2-decenoic acid. PubMed: Activity of 10-hydroxydecenoic acid from royal jelly against experimental leukaemia and ascitic tumours.