steareth-1

octadecyl polyoxyethylene ether

CAS: 9005-00-9 C20 H42 O2 MW: 314.55314000

Identification

Namesteareth-1
IUPAC2-octadecoxyethanol
CAS Number9005-00-9
FDA UNIISearch
Molecular FormulaC20 H42 O2
Molecular Weight314.55314000
Nikkaji NumberJ110.984G
XlogP38.40 (est)

Regulatory

FDA Mainterm (IAUFC)9005-00-9 ; PEG STEARYL ETHER

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 413.00 to 414.00 °C. @ 760.00 mm Hg (est)
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 7.966 (est)
Soluble in water, 0.01014 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessurfactants

Organoleptic Properties

Odor Strength none
Odor Description at 100.00 %.

Safety Information

Oral/Parenteral Toxicityoral-rat LD50 25000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemulsifiers, surfactants
Recommendation for steareth-1 usage levels up tonot for fragrance use.
Recommendation for steareth-1 flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2- octadecoxyethanol octadecyl polyoxyethylene ether polyoxyl stearyl ether PubMed: Surfactant effect on the physicochemical characteristics of cationic solid lipid nanoparticles. PubMed: A cost-effective method to prepare curcumin nanosuspensions with enhanced oral bioavailability. PubMed: A simple derivation of the critical condition for the ultrasonic atomization of polymer solutions. PubMed: Kinetically stable propofol emulsions with reduced free drug concentration for intravenous delivery. PubMed: The in vitro impact of toothpaste extracts on cell viability. PubMed: Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin. PubMed: Thermosensitive liposomes for the delivery of gemcitabine and oxaliplatin to tumors. PubMed: Key structure of brij for overcoming multidrug resistance in cancer. PubMed: EliA facilitates the induction of lipase expression by stearyl alcohol in Ralstonia sp. NT80. PubMed: Solubilisation capacity of Brij surfactants. PubMed: A thermosensitive liposome prepared with a Cu²⁺ gradient demonstrates improved pharmacokinetics, drug delivery and antitumor efficacy. PubMed: In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric ZEGFR domain. PubMed: Tailored microcrystal growth: a facile solution-phase synthesis of gold rings. PubMed: Efficient tumor regression by a single and low dose treatment with a novel and enhanced formulation of thermosensitive liposomal doxorubicin. PubMed: Tresyl-based conjugation of protein antigen to lipid nanoparticles increases antigen immunogenicity. PubMed: Development of the loratadine gel for enhanced transdermal delivery. PubMed: Templating multiple length scales by combining phase separation, self-assembly and photopatterning in porous films. PubMed: Preparation and characterization of solid lipid nanoparticles containing silibinin. PubMed: Cell-free production of G protein-coupled receptors for functional and structural studies. PubMed: Preparation and characterization of nickel nanoparticles for binding to his-tag proteins and antigens. PubMed: The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase. PubMed: Highly enantioselective epoxidation of 2,4-diarylenones by using dimeric cinchona phase-transfer catalysts: enhancement of enantioselectivity by surfactants. PubMed: Paclitaxel nanoparticles for the potential treatment of brain tumors. PubMed: A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test. PubMed: Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses. PubMed: Scale-up of an oil/water cream containing 40% diethylene glycol monoethyl ether. PubMed: Growth and survival of Helicobacter pylori in defined medium and susceptibility to Brij 78. PubMed: Inhibitory effects of polyoxyethylene stearate, PANTA, and neutral pH on growth of Mycobacterium genavense in BACTEC primary cultures. PubMed: Effect of Brij-78 on systemic delivery of insulin from an ocular device. PubMed: Immobilization of functionalized alkyl-poly(ethylene oxide) surfactants on poly(ethylene) surfaces by means of an argon plasma treatment. PubMed: Effects of the structures of polyoxyethylene alkyl ethers on uptake of butyl p-hydroxybenzoate by Escherichia coli and its antibacterial activity. PubMed: Albumin can reverse the release of potassium from human erythrocytes treated with the non-ionic detergent, Brij 58. PubMed: Feasibility of glucagon eyedrops for clinical use in hypoglycemia. PubMed: Chronic systemic delivery of insulin through the ocular route. PubMed: Enhancement of systemic delivery of met-enkephalin and leu-enkephalin eyedrops with permeation enhancers. PubMed: Effects of permeation enhancers BL-9 and Brij-78 on absorption of four peptide eyedrops in rabbits. PubMed: Glucagon administration to the rat via eye drops. PubMed: Systemic absorption of oxytocin and vasopressin through eyes in rabbits. PubMed: Effect of permeation enhancers on beta-endorphin systemic uptake after topical application to the eye. PubMed: Adjustment of blood sugar levels with insulin and glucagon eyedrops in normal and diabetic rabbits. PubMed: A nuclear magnetic resonance (nmr) investigation of the micellar structure of a long-chain non-ionic surfactant.