methyl paraben

methyl 4-hydroxybenzoate

CAS: 99-76-3 C8 H8 O3 MW: 152.14936000

Identification

Namemethyl paraben
IUPACmethyl 4-hydroxybenzoate
CAS Number99-76-3
EINECS202-785-7
FDA UNIIA2I8C7HI9T
Molecular FormulaC8 H8 O3
Molecular Weight152.14936000
MDL NumberMFCD00002352
Nikkaji NumberJ3.996I
Beilstein0509801
XlogP32.00 (est)

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices184.1490
JECFA Food AdditiveMethyl p-Hydroxybenzoate
GSFA CodexMethyl para-hydroxybenzoate (218)
DG SANTE Food Additivesmethyl p-hydroxybenzoate
DG SANTE Food Contact Materialsmethyl p-hydroxybenzoate
FEMA Number2710
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)99-76-3 ; METHYL P-HYDROXYBENZOATE
FDA RegulationFDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS

Physical Properties

Appearance white crystalline powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed Yes
Melting Point 125.00 to 128.00 °C. @ 760.00 mm Hg
Boiling Point 275.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.006000 mmHg @ 25.00 °C. (est)
Flash Point 241.00 °F. TCC ( 116.11 °C. )
logP (o/w) 1.960
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

Organoleptic Properties

Odor Description odorless

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 960 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 1200 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants and preservatives
Recommendation for methyl paraben usage levels up tonot for fragrance use.
baked goods5.00000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

preservatives

Natural Occurrence

not found in nature saffron

Synonyms

aseptoform benzoic acid, 4-hydroxy-, methyl ester benzoic acid, p-hydroxy-, methyl ester 4-( carbomethoxy)phenol p- carbomethoxyphenol para- carbomethoxyphenol 4- hydroxy methyl benzoate 4- hydroxy-benzoic acid methyl ester 4- hydroxybenzoic acid methyl ester p- hydroxybenzoic acid methyl ester para- hydroxybenzoic acid methyl ester 4- hydroxybenzoic acid methylester 4- hydroxybenzoic acid, methyl ester p- hydroxybenzoic acid, methyl ester p- hydroxybenzoic methyl ester killitol maseptol mekkings M metaben metagin methaben p- methoxycarbonyl phenol para- methoxycarbonyl phenol 4-( methoxycarbonyl) phenol 4-( methoxycarbonyl)phenol p- methoxycarbonylphenol methyl 4-hydroxybenzoate methyl butex methyl chemosept methyl ester of p-hydroxybenzoic acid methyl p-hydroxybenzoate methyl p-oxybenzoate methyl para-hydroxybenzoate methyl para-oxybenzoate methyl parabens (india) methyl parasept methyl-4-hydroxybenzoate methyl-4-hydroxybenzoate FCC methyl-p-hydroxybenzoate methyl-p-hydroxybenzoate NF methylben methylparaben metoxyde moldex nipagin para M paradol paridol preserval solbrol tegosept PubMed: Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes. PubMed: Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells. PubMed: Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products. PubMed: Prevalence of sensitivity to food and drug additives in patients with chronic idiopathic urticaria. PubMed: Antimicrobial and antibiofilm effects of selected food preservatives against Salmonella spp. isolated from chicken samples. PubMed: Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. PubMed: Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure. PubMed: Solubilization of parabens in aqueous Pluronic solutions: investigating the micellar growth and interaction as a function of paraben composition. PubMed: [Determination of sixteen food additives in beverage by capillary zone electrophoresis]. PubMed: Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three East Asian countries. PubMed: p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells. PubMed: Evaluation of the occurrence and biodegradation of parabens and halogenated by-products in wastewater by accurate-mass liquid chromatography-quadrupole-time-of-flight-mass spectrometry (LC-QTOF-MS). PubMed: Fast and sensitive high performance liquid chromatography analysis of cosmetic creams for hydroquinone, phenol and six preservatives. PubMed: Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage. PubMed: Use of a capillary tube for collecting an extraction solvent lighter than water after dispersive liquid-liquid microextraction and its application in the determination of parabens in different samples by gas chromatography--flame ionization detection. PubMed: Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006. PubMed: Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry. PubMed: Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. PubMed: Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. PubMed: Contribution to the study of the chemical composition of Verticillium albo-atrum secretions in liquid media. PubMed: [In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives]. PubMed: Evaluation of the health aspects of methyl paraben: a review of the published literature. PubMed: Interaction of p-hydroxybenzoic esters with beta-cyclodextrin. PubMed: Prediction of Listeria spp. growth as affected by various levels of chemicals, pH, temperature and storage time in a model broth. PubMed: Inhibition of Listeria monocytogenes and Salmonella enteriditis by combinations of plant oils and derivatives of benzoic acid: the development of synergistic antimicrobial combinations. PubMed: Irreversible paraben inhibition of glycolysis by Streptococcus mutans GS-5. PubMed: Effects of Sorbic Acid and Methyl Paraben on Susceptibility of Alfalfa Leafcutting Bees (Megachile rotundata) to Chalkbrood (Ascosphaera aggregata) PubMed: [Preservation and stability of corn tortillas at room temperature]. PubMed: Determination and confirmation of methyl p-hydroxybenzoate in royal jelly and other foods produced by the honey bee. PubMed: Relationships between the resistance of yeasts to acetic, propanoic and benzoic acids and to methyl paraben and pH. PubMed: Inhibition by antimicrobial food additives of ochratoxin A production by Aspergillus sulphureus and Penicillium viridicatum.