huperzine A

[5R-(5a,9b,11E)]-5- amino-11-ethylidene-5,8,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one (5R,9R,11E)-5- amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one (5R,9R)-5- amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one (1R,9R,13E)-1- amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one (1R,9R)-1- amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one huperaine A huperazine A (-)- huperzine A huperzine A (naturally extracted) huperzine A (synthetic) huperzine A 1% huperzine, 1% – 5% huperzine A 5,9- methanocycloocta(b)pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)- 5,9- methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)- 5,9- methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R)- selagine (-)- selagine PubMed: Biotransformation of Huperzine A by a Fungal Endophyte of Huperzia serrata Furnished Sesquiterpenoid-Alkaloid Hybrids. PubMed: Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A. PubMed: [Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors]. PubMed: Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer's Disease? PubMed: Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways. PubMed: Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus. PubMed: The neurovascular protective effects of huperzine a on d-galactose-induced inflammatory damage in the rat hippocampus. PubMed: The protective effect of huperzine A against hepatic ischemia reperfusion injury in mice. PubMed: Cholinesterase Inhibition in Alzheimer's Disease: Is Specificity the Answer? PubMed: Design, synthesis, and evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors. PubMed: Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways. PubMed: Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds. PubMed: Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation. PubMed: Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. PubMed: Marine natural products as acetylcholinesterase inhibitor: comparative quantum mechanics and molecular docking study. PubMed: A novel approach to medical countermeasures against organophosphorus compound toxicity. PubMed: Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. PubMed: A new role for the nonpathogenic nonsynonymous single-nucleotide polymorphisms of acetylcholinesterase in the treatment of Alzheimer's disease: a computational study. PubMed: Whole-Genome Shotgun Assembly and Analysis of the Genome of Shiraia sp. Strain Slf14, a Novel Endophytic Fungus Producing Huperzine A and Hypocrellin A. PubMed: Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins. PubMed: Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. PubMed: Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U. PubMed: Synergistic Effect and Mechanism of Cineole and Terpineol on In-vitro Transdermal Delivery of Huperzine A from Microemulsions. PubMed: Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. PubMed: Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms. PubMed: Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata. PubMed: Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PubMed: Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. PubMed: Huperzine A inhibits CCL2 production in experimental autoimmune encephalomyelitis mice and in cultured astrocyte. PubMed: [Effect of PNS on the activity and content of BACE1 in the brain of SAMP8 mice with Alzheimer's disease]. PubMed: Current acetylcholinesterase-inhibitors: a neuroinformatics perspective. PubMed: Controlled iontophoretic transport of huperzine A across skin in vitro and in vivo: effect of delivery conditions and comparison of pharmacokinetic models. PubMed: [Effect of litchi seed aqueous extracts on learning and memory obstacles induced by D-galactose in mice and its mechanism]. PubMed: [Determination of huperzine A and semi-quantitative RT-PCR analysis of lysine decarboxylase gene in different parts of Huperzia serrata from western Hunan]. PubMed: Natural products as sources of new lead compounds for the treatment of Alzheimer's disease. PubMed: Study of the interaction of Huperzia saururus Lycopodium alkaloids with the acetylcholinesterase enzyme. PubMed: The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat. PubMed: [Effect of Huperzine A on neural lesion of acute organophosphate poisoning in mice]. PubMed: [Determination of Huperzine A in the extract of Huperzia serrata by high performance liquid chromatography]. PubMed: [The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer's disease]. PubMed: Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease. PubMed: The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain. PubMed: Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026. PubMed: Eleutheroside B or E enhances learning and memory in experimentally aged rats. PubMed: Integrative proteomics. PubMed: Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert. PubMed: Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere. PubMed: Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. PubMed: Free energy landscape for the binding process of Huperzine A to acetylcholinesterase. PubMed: Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells. PubMed: Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A. PubMed: Multitarget drugs of plants origin acting on Alzheimer's disease. PubMed: The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice. PubMed: Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures. PubMed: [Effect and mechanism of dingzhixiao wan on scopolamine-induced learning-memory impairment in mice]. PubMed: Structural analogs of huperzine A improve survival in guinea pigs exposed to soman. PubMed: Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A. PubMed: A novel synthesis of (-)-huperzine A via tandem intramolecular aza-Prins cyclization-cyclobutane fragmentation. PubMed: Transepithelial transport of a natural cholinesterase inhibitor, huperzine A, along the gastrointestinal tract: the role of ionization on absorption mechanism. PubMed: Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam. PubMed: New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease. PubMed: The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats. PubMed: Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro. PubMed: Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. PubMed: Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice. PubMed: Huperzine A for mild cognitive impairment. PubMed: Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease. PubMed: Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart. PubMed: [Effect of Panax notoginseng saponins on expression of alpha-secretase mRNA in brains of senescence-accelerated SAMP8 mice]. PubMed: A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs. PubMed: The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells. PubMed: Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. PubMed: Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain. PubMed: New insights into huperzine A for the treatment of Alzheimer's disease. PubMed: On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis. PubMed: Molecular cloning and characterization of copper amine oxidase from Huperzia serrata. PubMed: An efficient total synthesis of (-)-huperzine A. PubMed: Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography. PubMed: Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors. PubMed: Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia. PubMed: Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD). PubMed: Examining the interactome of huperzine A by magnetic biopanning. PubMed: Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release. PubMed: Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships. PubMed: Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A. PubMed: Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice. PubMed: Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals. PubMed: Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease. PubMed: Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia. PubMed: Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations. PubMed: Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model. PubMed: Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis. PubMed: Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model. PubMed: Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography-tandem mass spectrometry. PubMed: Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease. PubMed: Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice. PubMed: Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets. PubMed: Treatment with Huperzine A improves cognition in vascular dementia patients. PubMed: [+]-Huperzine A protects against soman toxicity in guinea pigs. PubMed: Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies. PubMed: An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. PubMed: Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR. PubMed: The role of phytochemicals in the treatment and prevention of dementia. PubMed: Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation. PubMed: A phase II trial of huperzine A in mild to moderate Alzheimer disease. PubMed: Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants. PubMed: Preventing H₂O₂-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. PubMed: Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. PubMed: The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. PubMed: [Analysis of dynamic change of huperzine A content in Huperzia serrata]. PubMed: Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. PubMed: Modification and validation of a high-performance liquid chromatography method for quantification of Huperzine A in Huperzia crispata. PubMed: Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata. PubMed: Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors. PubMed: Pharmacological agents in the prophylaxis/treatment of organophosphorous pesticide intoxication. PubMed: Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. PubMed: Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method. PubMed: Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius. PubMed: Huperzine alkaloids from Australasian and southeast Asian Huperzia. PubMed: Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice. PubMed: Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats. PubMed: A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata. PubMed: Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers. PubMed: Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment. PubMed: Analysis of expressed sequence tags from the Huperzia serrata leaf for gene discovery in the areas of secondary metabolite biosynthesis and development regulation. PubMed: AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion. PubMed: Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. PubMed: Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre. PubMed: [Research advances of Huperzia serrata (Thunb.) Trev]. PubMed: Detection by UPLC/ESI-TOF-MS of alkaloids in three Lycopodiaceae species from French Polynesia and their anticholinesterase activity. PubMed: Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects. PubMed: [Release mechanism of huperzine-A swelling sustained-release tablets]. PubMed: Total synthesis of (-)-huperzine A. PubMed: Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. PubMed: Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats. PubMed: Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine. PubMed: A systematic review of single chinese herbs for Alzheimer's disease treatment. PubMed: Matrine determination and pharmacokinetics in human plasma using LC/MS/MS. PubMed: Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives. PubMed: Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids. PubMed: Chemical aspects of pharmacological prophylaxis against nerve agent poisoning. PubMed: Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. PubMed: Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog. PubMed: Drug development for Alzheimer's disease: where are we now and where are we headed? PubMed: Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment. PubMed: The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. PubMed: Huperzine A for vascular dementia. PubMed: BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide. PubMed: Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. PubMed: Lycojapodine A, a novel alkaloid from Lycopodium japonicum. PubMed: Role of huperzine a in the treatment of Alzheimer's disease. PubMed: Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. PubMed: Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins. PubMed: Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. PubMed: Review: insufficient evidence on Huperzine A for Alzheimer's. PubMed: Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization Fourier transform mass spectrometry. PubMed: Alternative medicine and Alzheimer disease. PubMed: The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. PubMed: Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs. PubMed: Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. PubMed: [Effects of microbes on rooting and on several physiological and biochemical indexes of cuttings of Huperzia serrata]. PubMed: [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. PubMed: Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. PubMed: Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia. PubMed: Comparison of methods used for the determination of cholinesterase activity in whole blood. PubMed: In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease. PubMed: Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia. PubMed: Flexibility versus "rigidity" of the functional architecture of AChE active center. PubMed: Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats. PubMed: Huperzine A for Alzheimer's disease. PubMed: Enzyme inhibitor screening by electrospray mass spectrometry with immobilized enzyme on magnetic silica microspheres. PubMed: [Progress of study on treatment of Alzheimer's disease with active ingredients of Chinese herbal medicines]. PubMed: Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. PubMed: Pharmacokinetics of huperzine A following oral administration to human volunteers. PubMed: Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs. PubMed: [Effects of huperzine A on cognitive function of rats recovering from general anesthesia]. PubMed: An update on huperzine A as a treatment for Alzheimer's disease. PubMed: Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method. PubMed: Huprines for Alzheimer's disease drug development. PubMed: Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. PubMed: Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis. PubMed: Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers. PubMed: The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine. PubMed: East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A. PubMed: Complete (1)H NMR spectral fingerprint of huperzine A. PubMed: Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. PubMed: Huperzine A from Huperzia species--an ethnopharmacolgical review. PubMed: Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats. PubMed: Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate. PubMed: Matrix-assisted laser desorption/ionization mass spectrometry (MALDI TOF MS) study of Huperzine A, a natural anti-Alzheimer's disease product, its derivatization and its detection by highly sensitive laser induced fluorescence (LIF). PubMed: Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha. PubMed: Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice. PubMed: Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector. PubMed: Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial. PubMed: The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse. PubMed: Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine. PubMed: Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors. PubMed: [Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration]. PubMed: Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury. PubMed: Huperzine A in rat plasma and CSF following intranasal administration. PubMed: Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats. PubMed: A concise and convergent (formal) total synthesis of huperzine A. PubMed: Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. PubMed: Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation. PubMed: Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. PubMed: Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography. PubMed: [Plant metabolites as nootropics and cognitives]. PubMed: [Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia]. PubMed: Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines. PubMed: Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge. PubMed: Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method. PubMed: Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. PubMed: The determination of huperzine A in European Lycopodiaceae species by HPLC-UV-MS. PubMed: [Effect of preparation technique on in vitro release mechanism of huperzine A microspheres]. PubMed: Editorial: natural products chemistry in China. PubMed: Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies. PubMed: Harmless herbs? Think again: merits of a complete medication history. PubMed: Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats. PubMed: [Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim]. PubMed: Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation. PubMed: Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. PubMed: Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs. PubMed: Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. PubMed: [Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning]. PubMed: Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. PubMed: Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds. PubMed: Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations. PubMed: Acetylcholinesterase triggers the aggregation of PrP 106-126. PubMed: Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. PubMed: Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. PubMed: [Synthesis and AchE inhibitory activity of 2-phenoxy-indan-1-one derivatives]. PubMed: Herbal medicine in the treatment of Alzheimer's disease. PubMed: Butyrylcholinesterase in guinea pig lung lavage: a novel biomarker to assess lung injury following inhalation exposure to nerve agent VX. PubMed: Application of L-Amino acid in determination of Huperzine A by high performance liquid chromatography. PubMed: [Effect of yizhi jiannao granule on the behavior and neuron apoptosis in SAMP/8 mice]. PubMed: High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts. PubMed: Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. PubMed: Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. PubMed: Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases. PubMed: In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid). PubMed: Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation. PubMed: Pharmacological strategies for the prevention of Alzheimer's disease. PubMed: Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. PubMed: A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales. PubMed: Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS. PubMed: Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection. PubMed: Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements. PubMed: Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman. PubMed: Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers. PubMed: Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors. PubMed: How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations. PubMed: Preparation and in vivo evaluation of huperzine A-loaded PLGA microspheres. PubMed: A survey of potential huperzine A natural resources in China: the Huperziaceae. PubMed: Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease. PubMed: Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks. PubMed: Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production. PubMed: Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. PubMed: Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease. PubMed: Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease. PubMed: [Advances on study of organophosphate poisoning prevented by Huperzine A]. PubMed: Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine. PubMed: Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. PubMed: Huperzine A--human serum albumin association: chromatographic and thermodynamic approach. PubMed: Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China. PubMed: Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum. PubMed: (+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration. PubMed: Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. PubMed: Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase. PubMed: The Lycopodium alkaloids. PubMed: Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease. PubMed: Protective effect of tetramethylpyrazine on learning and memory function in D-galactose-lesioned mice. PubMed: Recent pharmacological studies on natural products in China. PubMed: Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons. PubMed: Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons. 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PubMed: Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1. PubMed: Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. PubMed: Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. PubMed: Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. PubMed: Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. PubMed: Huperzine A. PubMed: Treatment of Alzheimer's disease. PubMed: [Pretreatment of organophosphate poisoning: potential interests of huperzine A]. 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