Identification

Namemethyl ortho-anisate
IUPACmethyl 2-methoxybenzoate
CAS Number606-45-1
EINECS210-118-6
FDA UNIISB18J2MCQL
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00008423
Nikkaji NumberJ47.046E
Beilstein2207356
CoE Number2192
XlogP32.00 (est)

Regulatory

JECFA Food Flavoring880 methyl o-methoxybenzoate
DG SANTE Food Flavourings09.796 methyl 2-methoxybenzoate
FEMA Number2717
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)606-45-1 ; METHYL O-METHOXYBENZOATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.15600 to 1.15900 @ 25.00 °C.
Pounds per Gallon - (est). 9.619 to 9.644
Refractive Index 1.53200 to 1.53500 @ 20.00 °C.
Melting Point 48.00 to 49.00 °C. @ 760.00 mm Hg
Boiling Point 254.00 to 255.00 °C. @ 760.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.029000 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 2.040
Soluble in alcohol
Insoluble in water
Stability cream

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Description
at 100.00 %.
Herbal, Floral, Hyacinth, Fruity

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3800 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for methyl ortho-anisate usage levels up to1.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)49.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)8.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

FR berry FR currant black currant FR fungus FR melon FL nut FR raspberry FL savory FL soup FL spinach FR strawberry FL vegetable FR wintergreen

Natural Occurrence

currant fruit grape hyacinthus orientalis absolute @ 0.01-0.10% Data mushroom PMC tea black tea ylang ylang oil @ 0.05% Data ylang ylang oil CO2 extract @ 0.04% Data

Synonyms

o- anisic acid methyl ester ortho- anisic acid methyl ester benzoic acid, 2-methoxy-, methyl ester dimethyl salicylate 2- methoxy-benzoic acid methyl ester 2- methoxybenzoic acid methyl ester o- methoxybenzoic acid methyl ester ortho- methoxybenzoic acid methyl ester o- methoxymethyl benzoate ortho- methoxymethyl benzoate methyl 2-methoxybenzoate methyl o-anisate methyl o-methoxy benzoate methyl o-methoxybenzoate methyl ortho anisate methyl ortho-methoxybenzoate methyl salicylate o-methyl ether methyl salicylate ortho-methyl ether methyl-2-methoxy benzoate PubMed: Copper-catalysed intramolecular O-arylation: a simple and efficient method for benzoxazole synthesis. PubMed: Attraction of the orange mint moth and false celery leaftier moth (Lepidoptera: Crambidae) to floral chemical lures. PubMed: Circumambulatory movement of negative charge ("ring walk") during gas-phase dissociation of 2,3,4-trimethoxybenzoate anion. PubMed: The first asymmetric total synthesis of (+)-coriandrone A and B. PubMed: Diagnosis of tuberculosis by trained African giant pouched rats and confounding impact of pathogens and microflora of the respiratory tract. PubMed: Synthesis of (+/-)- and (-)-vibralactone and vibralactone C. PubMed: Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. PubMed: Synthesis of (+/-)-vibralactone. PubMed: Optimization of the solid-phase microextraction method in the determination of Ixodes ricinus (L.) volatiles. PubMed: Field capture of northern and western corn rootworm beetles relative to attractant structure and volatility. PubMed: Methyl 2-(methylthio)benzoate: the unique sulfur-containing sex pheromone of Phyllophaga crinita. PubMed: Synthesis of geranyl phenyl ethers based on the cytotoxic monoterpenoids from the liverwort genus trichocolea