osteopontin
2ar peptide
Identification
| Name | osteopontin |
| CAS Number | 106441-73-0 |
| FDA UNII | Search |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 716 |
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | special dietary and nutritional additives |
| Recommendation for osteopontin usage levels up to | not for fragrance use. |
| Recommendation for osteopontin flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
2ar peptide
44 kda phosphoprotein
bone sialoprotein I
eta-1 protein
bovine milk
osteopontin
phosphoprotein I, 2aR
PubMed:
Pre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan® OPN-10.
PubMed:
Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse.
PubMed:
Seminal plasma proteome of electroejaculated Bos indicus bulls.
PubMed:
Stimulation of Osteogenic Activity in Human Osteoblast Cells by Edible Uraria crinita.
PubMed:
Age-related differences in kidney injury biomarkers induced by cisplatin.
PubMed:
Effect of Sleeve Gastrectomy on Osteopontin Circulating Levels and Expression in Adipose Tissue and Liver in Rats.
PubMed:
Increased blood-circulating interferon-γ, interleukin-17, and osteopontin levels in bovine paratuberculosis.
PubMed:
Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers.
PubMed:
Collagen hydrolysates increased osteogenic gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts.
PubMed:
An exploratory evaluation of the utility of transcriptional and urinary kidney injury biomarkers for the prediction of aristolochic acid-induced renal injury in male rats.
PubMed:
Unraveling the complexity of hepatitis B virus: from molecular understanding to therapeutic strategy in 50 years.
PubMed:
Serum osteopontin concentration is decreased by exercise-induced fat loss but is not correlated with body fat percentage in obese humans.
PubMed:
Change in kidney damage biomarkers after 13 weeks of exposing rats to the complex of Paecilomyces sinclairii and its host Bombyx mori larvae.
PubMed:
Effects of sodium citrate on melamine-cyanuric acid mixture-induced urolithiasis in rats.
PubMed:
Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns.
PubMed:
12 weeks' aerobic and resistance training without dietary intervention did not influence oxidative stress but aerobic training decreased atherogenic index in middle-aged men with impaired glucose regulation.
PubMed:
Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health.
PubMed:
Kidney injury biomarkers in hypertensive, diabetic, and nephropathy rat models treated with contrast media.
PubMed:
Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure.
PubMed:
Kidney Toxicity Induced by 13 Weeks Exposure to the Fruiting Body of Paecilomyces sinclairii in Rats.
PubMed:
Differential effects of high-fat-diet rich in lard oil or soybean oil on osteopontin expression and inflammation of adipose tissue in diet-induced obese rats.
PubMed:
Urinary biomarker detection of melamine- and cyanuric acid-induced kidney injury in rats.
PubMed:
Osteopontin is involved in estrogen-mediated protection against diethylnitrosamine-induced liver injury in mice.
PubMed:
Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370.
PubMed:
Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials.
PubMed:
Differentiation of osteoprogenitor cells is induced by high-frequency pulsed electromagnetic fields.
PubMed:
Biological activities of glucosamine and its related substances.
PubMed:
Proteomic analysis and immunodetection of the bovine milk osteopontin isoforms.
PubMed:
Comparison of the diagnostic accuracy of di-22:6-bis(monoacylglycerol)phosphate and other urinary phospholipids for drug-induced phospholipidosis or tissue injury in the rat.
PubMed:
Hepatic endothelin-1 and endocannabinoids-dependent effects of hyperleptinemia in nonalcoholic steatohepatitis-cirrhotic rats.
PubMed:
Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats.
PubMed:
Cadmium exposure activates the ERK signaling pathway leading to altered osteoblast gene expression and apoptotic death in Saos-2 cells.
PubMed:
Effects of water uptake on melamine renal stone formation in mice.
PubMed:
A Prunus mume extract stimulated the proliferation and differentiation of osteoblastic MC3T3-E1 cells.
PubMed:
Pro-bone and antifat effects of green tea and its polyphenol, epigallocatechin, in rat mesenchymal stem cells in vitro.
PubMed:
Renal glomerular and tubular injury after gastric bypass in obese rats.
PubMed:
Male reproductive traits and their relationship to reproductive traits in their female progeny: a systematic review.
PubMed:
Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells.
PubMed:
Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats.
PubMed:
Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats.
PubMed:
Identification of breast cancer biomarkers in transgenic mouse models: A proteomics approach.
PubMed:
Comparative studies on bone structure in dairy cows with different feeding conditions.
PubMed:
Mass spectrometry and renal calculi.
PubMed:
Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs.
PubMed:
Protective effects of bovine colostrum acid proteins on bone loss of ovariectomized rats and the ingredients identification.
PubMed:
Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals.
PubMed:
Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells.
PubMed:
Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.
PubMed:
Evaluation of subchronic toxicity of pet food contaminated with melamine and cyanuric acid in rats.
PubMed:
Osteopontin: an early innate immune marker of Escherichia coli mastitis harbors genetic polymorphisms with possible links with resistance to mastitis.
PubMed:
Seminal plasma proteins as potential markers of relative fertility in boars.
PubMed:
Calcium transport in strongly calcifying laying birds: mechanisms and regulation.
PubMed:
Preventive effects of nutritional doses of polyphenolic molecules on cardiac fibrosis associated with metabolic syndrome: involvement of osteopontin and oxidative stress.
PubMed:
The effect of weight loading and subsequent release from loading on the postnatal skeleton.
PubMed:
Aberrant expression of retinol-binding protein, osteopontin and fibroblast growth factor 7 in the porcine uterine endometrium of pregnant recipients carrying embryos produced by somatic cell nuclear transfer.
PubMed:
Osteoblast differentiation and bone formation gene expression in strontium-inducing bone marrow mesenchymal stem cell.
PubMed:
Effects of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester application.
PubMed:
Inhibitory activity of bovine milk osteopontin and its fragments on the formation of calcium phosphate precipitates.
PubMed:
Structural features of incremental line-like striations in mandibular condylar cartilage of c-src-deficient mice.
PubMed:
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects.
PubMed:
Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats.
PubMed:
The effect of vitamin K2 on bone metabolism in aged female rats.
PubMed:
Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation.
PubMed:
Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice.
PubMed:
The effect of altered functional forces on the expression of bone-matrix proteins in developing mouse mandibular condyle.
PubMed:
Vitamin A and carotenoids stimulate differentiation of mouse osteoblastic cells.