laevo-theanine

L-glutamine, N-ethyl-

CAS: 3081-61-6 C7 H14 N2 O3 MW: 174.20018000

Identification

Namelaevo-theanine
CAS Number3081-61-6
EINECS221-379-0
FDA UNII8021PR16QO
Molecular FormulaC7 H14 N2 O3
Molecular Weight174.20018000
MDL NumberMFCD00059653
Nikkaji NumberJ3.047C
Beilstein1725586
XlogP3-3.60 (est)

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 338

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 207.00 °C. @ 760.00 mm Hg
Boiling Point 430.00 to 431.00 °C. @ 760.00 mm Hg (est)
Flash Point 417.00 °F. TCC ( 214.00 °C. ) (est)
logP (o/w) -0.661 (est)
Soluble in water, 2.567e+004 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshumectants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryspecial dietary and nutritional additives
Recommendation for laevo-theanine usage levels up tonot for fragrance use.
Recommendation for laevo-theanine flavor usage levels up tonot for flavor use.

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Foreverest Resources Ltd.

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Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

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Potential Uses

None Found

Natural Occurrence

tea anther tea cotyledon tea leaf tea seed tea shoot tea stem

Synonyms

(2S)-2-2S)-2- amino-4-(N-ethylcarbamoyl)butanoic acid (2S)-2- amino-5-(ethylamino)-5-oxopentanoic acid (S)-2- amino-5-(ethylamino)-5-oxopentanoic acid N- ethyl-L-glutamine N- ethyl-laevo-glutamine L- glutamine, N-ethyl- suntheanine L- theanine PubMed: Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double-blind, placebo-controlled trial. J-Stage: The Involvement of L-Type Amino Acid Transporters in Theanine Transport PubMed: L-Theanin, Unique Aminoacid of Tea, and Its Metabolism, Health Effects, Safety. PubMed: Protective Effect of L-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway. PubMed: Quantification of total polyphenols, catechin, caffeine, L-theanine, determination of antioxidant activity and effect on antileishmanial drugs of ethiopian tea leaves extracts. PubMed: Fast Dissolving/Disintegrating Dosage Forms: Growth from Immediate Release to Sustained Release and Traditional Medicines. PubMed: Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration? PubMed: Epigallocatechin-3-gallate inhibits VCAM-1 expression and apoptosis induction associated with LC3 expressions in TNFα-stimulated human endothelial cells. PubMed: Effect of l-theanine on glutamatergic function in patients with schizophrenia. PubMed: An overview of biological production of L-theanine. PubMed: l-Theanine prevents carbon tetrachloride-induced liver fibrosis via inhibition of nuclear factor κB and down-regulation of transforming growth factor β and connective tissue growth factor. PubMed: A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. PubMed: In Search of a Safe Natural Sleep Aid. PubMed: Tea (Camellia Sinensis (L.)): a Putative Anticancer Agent in Bladder Carcinoma? PubMed: Tea (Camellia sinensis (L.)): a putative anticancer agent in bladder carcinoma? PubMed: Investigational drugs for anxiety in patients with schizophrenia. PubMed: Acute effects of dietary constituents on motor skill and cognitive performance in athletes. PubMed: L-theanine synthesis using γ-glutamyl transpeptidase from Bacillus licheniformis ER-15. PubMed: Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression. PubMed: Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives. PubMed: L-Theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin. PubMed: Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. PubMed: Mitochondrial toxic effects of Aβ through mitofusins in the early pathogenesis of Alzheimer's disease. PubMed: Protective effect of L-Theanine against aluminium induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain - histopathological, and biochemical approach. PubMed: L-Theanine elicits umami taste via the T1R1 + T1R3 umami taste receptor. PubMed: Identifying key non-volatile compounds in ready-to-drink green tea and their impact on taste profile. PubMed: Effect of L-theanine on sensorimotor gating in healthy human subjects. PubMed: Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum. PubMed: L-theanine (suntheanin): effects of L-theanine, an amino acid derived from Camellia sinensis (green tea), on stress response parameters. PubMed: Physiological effects of L-theanine on Drosophila melanogaster. PubMed: To sleep or not to sleep: a systematic review of the literature of pharmacological treatments of insomnia in children and adolescents with attention-deficit/hyperactivity disorder. PubMed: Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action. PubMed: Electron paramagnetic resonance studies of gamma-irradiated DL-alanine ethyl ester hydrochloride, L-theanine and L-glutamic acid dimethyl ester hydrochloride. PubMed: Effect of electrolyzed reduced water on chiral theanine and polyphenols in tea. PubMed: Protective effect of l-theanine on chronic restraint stress-induced cognitive impairments in mice. PubMed: L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. PubMed: L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway. PubMed: The involvement of L-type amino acid transporters in theanine transport. PubMed: [Mechanisms of cerebral protection from ischemia by tea constituents]. PubMed: Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. PubMed: L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. PubMed: Kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theanine via capsules and green tea. PubMed: l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice. PubMed: Rapid and selective quantification of L-theanine in ready-to-drink teas from Chinese market using SPE and UPLC-UV. PubMed: L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation. PubMed: Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice. PubMed: L-Theanine extends lifespan of adult Caenorhabditis elegans. PubMed: Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. PubMed: L-theanine partially counteracts caffeine-induced sleep disturbances in rats. PubMed: [Raman spectral analysis of theanine]. PubMed: Tea and cognitive health in late life: current evidence and future directions. PubMed: The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. PubMed: Nerve and behavioral responses of mice to various umami substances. PubMed: l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes. PubMed: Behavioral and molecular evidence for psychotropic effects in L-theanine. PubMed: Optimum conditions for the water extraction of L-theanine from green tea. PubMed: L-Theanine: properties, synthesis and isolation from tea. PubMed: Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients. PubMed: Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice. PubMed: Production of bioactive γ-glutamyl transpeptidase in Escherichia coli using SUMO fusion partner and application of the recombinant enzyme to L-theanine synthesis. PubMed: A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. PubMed: L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. PubMed: A randomized targeted amino acid therapy with behaviourally at-risk adopted children. PubMed: The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. PubMed: L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. PubMed: Anxiolytic effects of L-theanine--a component of green tea--when combined with midazolam, in the male Sprague-Dawley rat. PubMed: L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. PubMed: Effects of (L)-cystine and (L)-theanine supplementation on the common cold: a randomized, double-blind, and placebo-controlled trial. PubMed: Neuroprotection by radical avoidance: search for suitable agents. PubMed: Combined administration of (L)-cystine and (L)-theanine enhances immune functions and protects against influenza virus infection in aged mice. PubMed: l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways. PubMed: Impact of two types of Internet-based information on medical students' performance in an Objective Structured Clinical Exam (OSCE). PubMed: Co-administration of l-cystine and l-theanine enhances efficacy of influenza vaccination in elderly persons: nutritional status-dependent immunogenicity. PubMed: Tea and health: preventive and therapeutic usefulness in the elderly? PubMed: L-theanine elicits an umami taste with inosine 5'-monophosphate. PubMed: The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. PubMed: The combined effects of L-theanine and caffeine on cognitive performance and mood. PubMed: L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. PubMed: L-theanine, a natural constituent in tea, and its effect on mental state. PubMed: Immobilization of Escherichia coli novablue gamma-glutamyltranspeptidase in Ca-alginate-kappa-carrageenan beads. PubMed: Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. PubMed: Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells. PubMed: L-theanine intervention enhances human gammadeltaT lymphocyte function. PubMed: Psychological effects of dietary components of tea: caffeine and L-theanine. PubMed: Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine. PubMed: [Separation and quantification of theanine enantiomers using high performance liquid chromatography coupled with chiral derivatization]. PubMed: Bioactive food components that enhance gammadelta T cell function may play a role in cancer prevention. PubMed: Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin. PubMed: The effects of L-theanine, caffeine and their combination on cognition and mood. PubMed: Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: II. Characterization in the freely moving rat by means of quantitative field potential analysis. PubMed: Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: I. electrophysiological characterization in the rat hippocampus in-vitro. PubMed: Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. PubMed: The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. PubMed: Expression optimization and biochemical characterization of a recombinant gamma-glutamyltranspeptidase from Escherichia coli novablue. PubMed: Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. PubMed: L-Theanine reduces psychological and physiological stress responses. PubMed: A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats. PubMed: Molecular and sensory studies on the umami taste of Japanese green tea. PubMed: L-theanine . Monograph. PubMed: Pharmacokinetics of theanine enantiomers in rats. PubMed: The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. PubMed: Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry. PubMed: Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses.