citrulline malate
(2S)-2-amino-5-(carbamoylamino)pentanoic acid; 2-hydroxybutanedioic acid
Identification
| Name | citrulline malate |
| CAS Number | 54940-97-5 |
| FDA UNII | PAB4036KHO |
| Molecular Formula | C10 H19 N3 O8 |
| Molecular Weight | 309.27603000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 386.00 to 387.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point | 370.00 °F. TCC ( 187.70 °C. ) (est) |
| logP (o/w) | -1.526 (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | special dietary and nutritional additives |
| Recommendation for citrulline malate usage levels up to | not for fragrance use. |
| Recommendation for citrulline malate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(2S)-2-
amino-5-(carbamoylamino)pentanoic acid; 2-hydroxybutanedioic acid
PubMed:
Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: A clinical trial.
PubMed:
The new metabolic treatments for sarcopenia.
PubMed:
Arginine and citrulline supplementation in sports and exercise: ergogenic nutrients?
PubMed:
Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle.
PubMed:
Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction.
PubMed:
L-citrulline-malate influence over branched chain amino acid utilization during exercise.
PubMed:
Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.
PubMed:
Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise.
PubMed:
Beneficial effects of citrulline malate on skeletal muscle function in endotoxemic rat.
PubMed:
Citrulline/malate promotes aerobic energy production in human exercising muscle.
PubMed:
[Use of citrulline malate (stimol) in patients with autonomic dystonia associated with arterial hypotension].
PubMed:
[Autonomic disorders in persons with asthenic syndrome and their correction with citrulline malate].
PubMed:
Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins.
PubMed:
Effects of citrulline malate on bacterial lipopolysaccharide induced endotoxemia in rats.
PubMed:
Use of a microbial model for the determination of drug effects on cell metabolism and energetics: study of citrulline-malate.
PubMed:
Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man.
PubMed:
Citrulline-malate effect on microsome phospholipids and cytochrome P450 in Euglena grown with ethanol.
PubMed:
Effects of a first exposure to ethanol on the compositions of neutral and polar lipids in Euglena gracilis Z, taken as a hepatic cell model: equilibration by citrulline-malate.