laevo-alpha-glyceryl phosphoryl choline

L-alpha-glycerylphosphorylcholine

CAS: 28319-77-9 C8 H20 N O6 P MW: 257.22336200

Identification

Namelaevo-alpha-glyceryl phosphoryl choline
CAS Number28319-77-9
EINECS248-962-2
FDA UNII60M22SGW66
Molecular FormulaC8 H20 N O6 P
Molecular Weight257.22336200
MDL NumberMFCD00063544
Beilstein6062450

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 419

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 142.50 °C. @ 760.00 mm Hg
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -5.398 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 > 13000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for laevo-alpha-glyceryl phosphoryl choline usage levels up tonot for fragrance use.
Recommendation for laevo-alpha-glyceryl phosphoryl choline flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

alpha-GPC choline alfoscerate [(2R)-2,3- dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate L-alpha- glycerophosphocholine L-alpha- glycerophosphorylcholine L-alpha- glyceryl phosphoryl choline L-alpha- glycerylphosphorylcholine laevo-alpha- glycerylphosphorylcholine PubMed: Excessive alcohol consumption induces methane production in humans and rats. PubMed: [Detection of effective treatment of amnestic mild cognitive impairement with cereton by testing of lipids markers]. PubMed: Unexpected effects of acetylcholine precursors on pilocarpine seizure-induced neuronal death. PubMed: [A comparative chemoreactome analysis of mexidol]. PubMed: [Combined therapy of cerebrovascular disorders with neuroprotectors]. PubMed: Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine. PubMed: Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. PubMed: l-Alpha Glycerylphosphorylcholine as a Potential Radioprotective Agent in Zebrafish Embryo Model. PubMed: [Analysis of choline alfoscerate effectiveness in chronic ocular ischemic syndrome]. PubMed: [Pathogenetic approaches to treatment of cognitive disorders in patients with diabetes mellitus]. PubMed: Phospholipase A1-catalyzed hydrolysis of soy phosphatidylcholine to prepare l-α-glycerylphosphorylcholine in organic-aqueous media. PubMed: Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections. PubMed: Radio-neuroprotective effect of L-alpha-glycerylphosphorylcholine (GPC) in an experimental rat model. PubMed: Protective effects of L-alpha-glycerylphosphorylcholine on ischaemia-reperfusion-induced inflammatory reactions. PubMed: L-α-glycerylphosphorylcholine reduces the microcirculatory dysfunction and nicotinamide adenine dinucleotide phosphate-oxidase type 4 induction after partial hepatic ischemia in rats. PubMed: Peripheral inflammatory activation after hippocampus irradiation in the rat. PubMed: [The use of choline alfoscerate (gliatiline) in patients with ischemic stroke]. PubMed: [Approaches to the treatment of tympanophonia taking into consideration specific psychological features of the patient]. PubMed: Modulation of monoaminergic transporters by choline-containing phospholipids in rat brain. PubMed: Methane biogenesis during sodium azide-induced chemical hypoxia in rats. PubMed: [Influence of neuroprotectors with choline-positive action on the level of brain-injury markers during acute ischemic stroke]. PubMed: [The use of cerepro (choline alfoscerate) in the treatment of outpatients with chronic progressive cerebrovascular disease]. PubMed: Purification of L-alpha glycerylphosphorylcholine by column chromatography. PubMed: Effects of cholinergic agonists and antagonists under conditions of spleen denervation in rats with endotoxic shock. PubMed: [Anti-inflammatory role of cholinergic and serotonergic systems in shock]. PubMed: [Efficacy of cereton in the acute period of ischemic stroke]. PubMed: [Use of cholinomimetics in the treatment of endogenous autism in children]. PubMed: L-alpha-glycerylphosphorylcholine inhibits the transfer function of phosphatidylinositol transfer protein alpha. PubMed: Treatment of dementia with neurotransmission modulation. PubMed: Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. PubMed: L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study. PubMed: Effect of L-alpha glycerylphosphorylcholine on muscarinic receptors and membrane microviscosity of aged rat brain. PubMed: Long term choline alfoscerate treatment counters age-dependent microanatomical changes in rat brain. PubMed: Choline acetyltransferase and acetylcholinesterase in the hippocampus of aged rats: sensitivity to choline alphoscerate treatment. PubMed: Effect of ipsilateral lesioning of the nucleus basalis magnocellularis and of L-alpha-glyceryl phosphorylcholine treatment on choline acetyltransferase and acetylcholinesterase in the rat fronto-parietal cortex. PubMed: Cholinergic neurotransmission in the hippocampus of aged rats: influence of L-alpha-glycerylphosphorylcholine treatment. PubMed: Effect of acute and short-term administration of cholinomimetic drugs on corticosterone secretion in the rat. PubMed: Nerve growth factor receptor immunoreactivity in the cerebellar cortex of aged rats: effect of choline alfoscerate treatment. PubMed: Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. PubMed: A comparative study of free plasma choline levels following intramuscular administration of L-alpha-glycerylphosphorylcholine and citicoline in normal volunteers. PubMed: Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. PubMed: Effect of choline alfoscerate treatment on changes in rat hippocampus mossy fibres induced by monolateral lesioning of the nucleus basalis magnocellularis. PubMed: L-alpha-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the rat. PubMed: Behavioral effects of L-alpha-glycerylphosphorylcholine: influence on cognitive mechanisms in the rat. PubMed: Oral choline alfoscerate counteracts age-dependent loss of mossy fibres in the rat hippocampus. PubMed: Age-related structural changes in the rat cerebellar cortex: effect of choline alfoscerate treatment. PubMed: Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. PubMed: Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. PubMed: Changes in the interaction between CNS cholinergic and dopaminergic neurons induced by L-alpha-glycerylphosphorylcholine, a cholinomimetic drug. PubMed: [STUDIES ON THE HYDROLYSIS OF LECITHINE WITH HYDROXIDES OF ALKALINE EARTH METALS AND THE PREPARATION OF L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE]. PubMed: Synthesis of saturated and unsaturated L-alpha-lecithins; acylation of the cadmium chloride compound of L-alpha-glycerylphosphorylcholine. PubMed: The preparation of lecithin from L-alpha-glycerylphosphorylcholine. PubMed: An enzymatic route to L-alpha-glycerylphosphorylcholine. PubMed: The preparation of L-alpha-glycerylphosphorylcholine from lecithins. PubMed: L-alpha-glycerylphosphorylcholine.