urolithin B

6H-dibenzo[b,d]pyran-6-one, 3-hydroxy-

CAS: 1139-83-9 C13 H8 O3 MW: 212.20436000

Identification

Nameurolithin B
CAS Number1139-83-9
FDA UNIIB1S2YM5F6G
Molecular FormulaC13 H8 O3
Molecular Weight212.20436000
MDL NumberMFCD00034338
Nikkaji NumberJ13.162H

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 432.55 °C. @ 760.00 mm Hg (est)
Flash Point 386.00 °F. TCC ( 196.60 °C. ) (est)
logP (o/w) 2.947 (est)
Soluble in water, 576.7 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for urolithin B usage levels up tonot for fragrance use.
Recommendation for urolithin B flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

pomegranate fruit raspberry red raspberry fruit strawberry wild strawberry fruit

Synonyms

6H- dibenzo(b,d)pyran-6-one, 3-hydroxy- 6H- dibenzo[b,d]pyran-6-one, 3-hydroxy- 3- hydroxy-6H-benzo[c]chromen-6-one 3- hydroxy-benzo[c]chromen-6-one 3- hydroxybenzo[c]chromen-6-one PubMed: Gastrointestinal stability of urolithins: an in vitro approach. PubMed: Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells. PubMed: Preparative isolation and purification of urolithins from the intestinal metabolites of pomegranate ellagitannins by high-speed counter-current chromatography. PubMed: Pilot walnut intervention study of urolithin bioavailability in human volunteers. PubMed: Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species. PubMed: Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells. PubMed: Influence of gut microbiota-derived ellagitannins' metabolites urolithins on pro-inflammatory activities of human neutrophils. PubMed: Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. PubMed: Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. PubMed: Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. PubMed: Urolithins display both antioxidant and pro-oxidant activities depending on assay system and conditions. PubMed: Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells. PubMed: In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. PubMed: Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells. PubMed: Intestinal ellagitannin metabolites ameliorate cytokine-induced inflammation and associated molecular markers in human colon fibroblasts. PubMed: Metabolism of oak leaf ellagitannins and urolithin production in beef cattle. PubMed: Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans. PubMed: Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. PubMed: Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. PubMed: Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. PubMed: Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. PubMed: A concise synthesis of glucuronide metabolites of urolithin-B, resveratrol, and hydroxytyrosol. PubMed: Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1. PubMed: Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. PubMed: Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans. PubMed: Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers. PubMed: Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. PubMed: Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities. PubMed: Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability.