monosodium glutamate

MSG

CAS: 142-47-2 C5 H9 N O4 Na MW: 170.12029928 salty

Identification

Namemonosodium glutamate
IUPACsodium 2-amino-5-hydroxy-5-oxopentanoate
CAS Number142-47-2
EINECS205-538-1
FDA UNIIC3C196L9FG
Molecular FormulaC5 H9 N O4 Na
Molecular Weight170.12029928
MDL NumberMFCD00150138
CoE Number11898

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices182.1
JECFA Food AdditiveMonosodium L-Glutamate
GSFA CodexMonosodium glutamate (621)
DG SANTE Food Additivesmonosodium glutamate
FEMA Number2756
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)142-47-2 ; MONOSODIUM GLUTAMATE
FDA RegulationFDA PART 101 -- FOOD LABELING

Physical Properties

Appearance white colorless crystalline powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 230.00 to 232.00 °C. @ 760.00 mm Hg
Boiling Point 333.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000025 mmHg @ 25.00 °C. (est)
Flash Point 312.00 °F. TCC ( 155.70 °C. ) (est)
logP (o/w) -1.435 (est)
Shelf Life 12.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in ethyl alcohol, slightly

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength low
Odor Description at 100.00 %.
Taste Description salty meaty

Safety Information

European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 16600 mg/kg
Dermal Toxicitysubcutaneous-cat LD50 8000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor enhancers
Recommendation for monosodium glutamate usage levels up tonot for fragrance use.
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

biological additives FL chicken hair conditioning skin conditioning

Natural Occurrence

not found in nature

Synonyms

glutacyl L- glutamic acid monosodium salt laevo- glutamic acid monosodium salt glutamic acid sodium salt DL- glutamic acid sodium salt glutamic acid, monosodium salt glutamic acid, sodium salt (1:1) glutamic acid, sodium salt(1:1) glutavene M.S.G. MSG pentanedioate, 2-amino-, hydrogen sodium salt (1:1:1) sodium 2-amino-4-carboxybutanoate sodium 2-amino-5-hydroxy-5-oxopentanoate sodium 2-ammoniopentanedioate sodium 2-azaniumylpentanedioate sodium 5-oxido-5-oxonorvaline sodium glutamate DL-mono sodium glutamate sodium hydrogen 2-aminopentanedioate (1:1:1) sodium hydrogen glutamate Info: Monosodium Glutamate PubMed: Supplementing chicken broth with monosodium glutamate reduces energy intake from high fat and sweet snacks in middle-aged healthy women. PubMed: Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death. PubMed: Persistent enhancement of ethanol drinking following a monosodium glutamate-substitution procedure in C57BL6/J and DBA/2J mice. PubMed: Dried bonito dashi: a preferred fish broth without postoral reward actions in mice. PubMed: To study the effect of monosodium glutamate on histomorphometry of cortex of kidney in adult albino rats. PubMed: Flavor preferences conditioned by oral monosodium glutamate in mice. PubMed: Flavor preferences conditioned by intragastric monosodium glutamate in mice. PubMed: Intragastric administration of glutamate increases REM sleep in rats. PubMed: Umami evaluation in taste epithelium on microelectrode array by extracellular electrophysiological recording. PubMed: Application of Diet-derived Taste Active Components for Clinical Nutrition: Perspectives from Ancient AyurvedicMedical Science, Space Medicine, and Modern Clinical Nutrition. PubMed: Neonatal treatment with monosodium glutamate lastingly facilitates spreading depression in the rat cortex. PubMed: Long-term ingestion of monosodium L-glutamate did not induce obesity, dyslipidemia or insulin resistance: a two-generation study in mice. PubMed: Effect of flavor enhancers on the nutritional status of older persons. PubMed: Flavor preferences conditioned by postingestive effect of sucrose and porcine digestive peptides in postweaning pigs. PubMed: Restoration of brain antioxidant status by hydroalcoholic extract of Mimusops elengi flowers in rats treated with monosodium glutamate. PubMed: N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models. PubMed: No effects of monosodium glutamate consumption on the body weight or composition of adult rats and mice. PubMed: MSG intake and preference in mice are influenced by prior testing experience. PubMed: The effect of vitamin C administration on monosodium glutamate induced liver injury. An experimental study. PubMed: Somatosensory factors in taste perception: effects of active tasting and solution temperature. PubMed: Sensory characteristics and consumer acceptability of beef stock containing the glutathione-xylose Maillard reaction product and/or monosodium glutamate. PubMed: Sensory characteristics and cross-cultural consumer acceptability of Bulgogi (Korean traditional barbecued beef). PubMed: Sub-chronic concomitant ingestion of L-arginine and monosodium glutamate improves feed efficiency, lipid metabolism and antioxidant capacity in male Wistar rats. PubMed: Effect of monosodium glutamate on lipid peroxidation and certain antioxidant enzymes in cardiac tissue of alcoholic adult male mice. PubMed: Preparation of culinary-medicinal king oyster mushroom Pleurotus eryngii-fermented products with high ergothioneine content and their taste quality. PubMed: Pilot study on which foods should be avoided by patients with psoriasis. PubMed: Preparation of Chaga medicinal mushroom, Inonotus obliquus-fermented rice using solid-state fermentation and its taste quality and antioxidant property. PubMed: Central representation of postingestive chemosensory cues in mice that lack the ability to taste. PubMed: Flavor preferences conditioned by post-oral infusion of monosodium glutamate in rats. PubMed: Sensory characteristics and consumer acceptability of fermented soybean paste (Doenjang). PubMed: Impacts of glutathione Maillard reaction products on sensory characteristics and consumer acceptability of beef soup. PubMed: Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults: China Health and Nutrition Survey (CHNS). PubMed: Effects of ad libitum ingestion of monosodium glutamate on weight gain in C57BL6/J mice. PubMed: Effects of monosodium glutamate supplementation on glutamine metabolism in adult rats. PubMed: The role of ascorbic acid and monosodium glutamate in thymocyte apoptosis. PubMed: Sensory characteristics and consumer acceptability of beef soup with added glutathione and/or MSG. PubMed: Glutamate. Its applications in food and contribution to health. PubMed: Brain-gut communication via vagus nerve modulates conditioned flavor preference. PubMed: Deciphering the MSG controversy. PubMed: The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice. PubMed: Optimal preferred MSG concentration in potatoes, spinach and beef and their effect on intake in institutionalized elderly people. PubMed: Sensory and receptor responses to umami: an overview of pioneering work. PubMed: Functional neuroimaging of umami taste: what makes umami pleasant? PubMed: Ascorbic acid modulates monosodium glutamate induced cytotoxicity in rat thymus. PubMed: No effect on intake and liking of soup enhanced with mono-sodium glutamate and celery powder among elderly people with olfactory and/or gustatory loss. PubMed: Saltiness enhancement by the characteristic flavor of dried bonito stock. PubMed: Conditioned flavor preference learning by intragastric administration of L-glutamate in rats. PubMed: Brain activation by umami substances via gustatory and visceral signaling pathways, and physiological significance. PubMed: Experimental studies of food choices and palatability responses in European subjects exposed to the Umami taste. PubMed: Acquired flavor acceptance and intake facilitated by monosodium glutamate in humans. PubMed: Sources of umami taste in Cheddar and Swiss cheeses. PubMed: Molecular and sensory characterization of gamma-glutamyl peptides as key contributors to the kokumi taste of edible beans (Phaseolus vulgaris L.). PubMed: [Effects of food supplements on the safety and quality of seafoods]. PubMed: Effect of monosodium glutamate on apoptosis and Bcl-2/Bax protein level in rat thymocyte culture. PubMed: Consensus meeting: monosodium glutamate - an update. PubMed: No effect of 16 weeks flavor enhancement on dietary intake and nutritional status of nursing home elderly. PubMed: Monosodium glutamate in its anhydrous and monohydrate form: differentiation by Raman spectroscopies and density functional calculations. PubMed: Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin. PubMed: Taste quality of monascal adlay. PubMed: Effects of added glutamate on liking for novel food flavors. PubMed: Responses to di-sodium guanosine 5'-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae. PubMed: MSG. A common flavor enhancer. PubMed: Oral health, taste, and olfaction. PubMed: Effect of taste and smell on secretion rate of salivary IgA in elderly and young persons. PubMed: Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. PubMed: Peripheral glutamate receptors: molecular biology and role in taste sensation. PubMed: The representation of umami taste in the taste cortex. PubMed: Intensification of sensory properties of foods for the elderly. PubMed: Glutamate and the flavor of foods. PubMed: Portal hyperglutamatemia after dietary supplementation with monosodium glutamate in pigs. PubMed: Effects of monosodium glutamate on human food palatability. PubMed: The neurophysiology of taste and olfaction in primates, and umami flavor. PubMed: Flavor characteristics of glutathione in raw and cooked foodstuffs. PubMed: Stimulus specificity in flavor acceptance learning. PubMed: Are the tastes of polycose and monosodium glutamate unique? PubMed: Dietary preferences in early lactation cows as affected by primary tastes and some common feed flavors. PubMed: Evaluation of free D-glutamate in processed foods. PubMed: A report of the proceedings of an MSG workshop held August 1991. PubMed: Simultaneous determination of flavor enhancers inosine 5'-monophosphate and guanosine 5'-monophosphate in food preparations by derivative spectrophotometry. PubMed: Preference of Old World monkeys for amino acids and other gustatory stimuli: the influence of monosodium glutamate. PubMed: Parabrachial gustatory neural responses to monosodium glutamate ingested by awake rats. PubMed: MSG and hydrolyzed vegetable protein induced headache: review and case studies. PubMed: Can sodium contents of foods be reduced by adding flavors? Studies with beef broth. PubMed: [Adverse reactions induced by food additives: sulfites]. PubMed: Monosodium L-glutamate-induced asthma. PubMed: Synergistic effects of 5'-nucleotides on rat taste responses to various amino acids. PubMed: Flavor potentiators. PubMed: Flavor preferences in malnourished Mexican infants. PubMed: A flavor panel study of the application of monosodium glutamate to the flavor of pharmaceutical products.