urolithin C
6H-dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-
Identification
| Name | urolithin C |
| CAS Number | 165393-06-6 |
| FDA UNII | Search |
| Molecular Formula | C13 H8 O5 |
| Molecular Weight | 244.20276000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 605.38 °C. @ 760.00 mm Hg (est) |
| Flash Point | 470.00 °F. TCC ( 243.60 °C. ) (est) |
| logP (o/w) | 1.615 (est) |
| Soluble in | water, 2565 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for urolithin C usage levels up to | not for fragrance use. |
| Recommendation for urolithin C flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
6H-
dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-
3,8,9-
trihydroxybenzo[c]chromen-6-one
PubMed:
In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepaten(®) Formulation.
PubMed:
The ellagitannin colonic metabolite urolithin D selectively inhibits EphA2 phosphorylation in prostate cancer cells.
PubMed:
Pilot walnut intervention study of urolithin bioavailability in human volunteers.
PubMed:
Influence of gut microbiota-derived ellagitannins' metabolites urolithins on pro-inflammatory activities of human neutrophils.
PubMed:
Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials.
PubMed:
Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species.
PubMed:
Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells.
PubMed:
Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome.
PubMed:
Extracts from Epilobium sp. herbs, their components and gut microbiota metabolites of Epilobium ellagitannins, urolithins, inhibit hormone-dependent prostate cancer cells-(LNCaP) proliferation and PSA secretion.
PubMed:
The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota.
PubMed:
Colon cancer chemopreventive activities of pomegranate ellagitannins and urolithins.
PubMed:
Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.
PubMed:
Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans.