serralysin
enzyme produced by the fermentation of serratia marcescens
Identification
| Name | serralysin |
| CAS Number | 37312-62-2 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | ['cosmetic data2', 'cosmetic data'] |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 15200 ug/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 44 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emollients, skin conditioning |
| Recommendation for serralysin usage levels up to | not for fragrance use. |
| Recommendation for serralysin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
enzyme produced by the fermentation of serratia marcescens
serratia marcescens ferment
PubMed:
Pathogenicity of Isolates of Serratia Marcescens towards Larvae of the Scarab Phyllophaga Blanchardi (Coleoptera).
J-Stage:
Regulation of Chitinase Production by the 5'-Untranslated Region of the ybfM in Serratia marcescens 2170
PubMed:
Identification of SlpB, a Cytotoxic Protease from Serratia marcescens.
PubMed:
Virulence factors contributing to invasive activities of Serratia grimesii and Serratia proteamaculans.
PubMed:
Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors.
PubMed:
Molecular detection and analysis of a novel metalloprotease gene of entomopathogenic Serratia marcescens strains in infected Galleria mellonella.
PubMed:
Assessing the exoproteome of marine bacteria, lesson from a RTX-toxin abundantly secreted by Phaeobacter strain DSM 17395.
PubMed:
Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori.
PubMed:
Serratia marcescens suppresses host cellular immunity via the production of an adhesion-inhibitory factor against immunosurveillance cells.
PubMed:
A fibrinolytic, alkaline and thermostable metalloprotease from the newly isolated Serratia sp RSPB11.
PubMed:
In vivo monitoring of Yersinia ruckeri in fish tissues: progression and virulence gene expression.
PubMed:
Phylogeny of bacteria isolated from Rhabditis sp. (Nematoda) and identification of novel entomopathogenic Serratia marcescens strains.
PubMed:
Mutation of crp mediates Serratia marcescens serralysin and global secreted protein production.
PubMed:
Comparison of the binding specificity of two bacterial metalloproteases, LasB of Pseudomonas aeruginosa and ZapA of Proteus mirabilis, using N-alpha mercaptoamide template-based inhibitor analogues.
PubMed:
Enzymatic characterization of a serralysin-like metalloprotease from the entomopathogen bacterium, Xenorhabdus.
PubMed:
A subset of metzincins and related genes constitutes a marker of human solid organ fibrosis.
PubMed:
Proteolytic enzyme production by strains of the insect pathogen xenorhabdus and characterization of an early-log-phase-secreted protease as a potential virulence factor.
PubMed:
Cloning, expression, and identification of a novel extracellular cold-adapted alkaline protease gene of the marine bacterium strain YS-80-122.
PubMed:
Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site.
PubMed:
Identification of natural target proteins indicates functions of a serralysin-type metalloprotease, PrtA, in anti-immune mechanisms.
PubMed:
A novel serralysin metalloprotease from Deinococcus radiodurans.
PubMed:
A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors.
PubMed:
Bioconversion of squid pen by Lactobacillus paracasei subsp paracasei TKU010 for the production of proteases and lettuce growth enhancing biofertilizers.
PubMed:
Biochemical and genetic characterization of arazyme, an extracellular metalloprotease produced from Serratia proteamaculans HY-3.
PubMed:
Characterization and role of a metalloprotease induced by chitin in Serratia sp. KCK.
PubMed:
Cleavage site analysis of a serralysin-like protease, PrtA, from an insect pathogen Photorhabdus luminescens and development of a highly sensitive and specific substrate.
PubMed:
Serratia marcescens serralysin induces inflammatory responses through protease-activated receptor 2.
PubMed:
Complex regulation of AprA metalloprotease in Pseudomonas fluorescens M114: evidence for the involvement of iron, the ECF sigma factor, PbrA and pseudobactin M114 siderophore.
PubMed:
Contribution of a single-turn alpha-helix to the conformational stability and activity of the alkaline proteinase inhibitor of Pseudomonas aeruginosa.
PubMed:
Proteus mirabilis ZapA metalloprotease degrades a broad spectrum of substrates, including antimicrobial peptides.
PubMed:
In vitro and in vivo studies of the Yrp1 protease from Yersinia ruckeri and its role in protective immunity against enteric red mouth disease of salmonids.
PubMed:
Self-assembly of proteins into designed networks.
PubMed:
Alkaline proteinase inhibitor of Pseudomonas aeruginosa: a mutational and molecular dynamics study of the role of N-terminal residues in the inhibition of Pseudomonas alkaline proteinase.
PubMed:
The Cu(II) acetate complex of the heteroscorpionate ligand (2-hydroxy-3-t-butyl-methylphenyl)bis(3,5-dimethylpyrazolyl)methane: a structural model for copper-substituted serralysin and astacin.
PubMed:
Elastase-producing Pseudomonas aeruginosa degrade plasma proteins and extracellular products of human skin and fibroblasts, and inhibit fibroblast growth.
PubMed:
Typing of Pseudomonas aeruginosa strains in Turkish cystic fibrosis patients.
PubMed:
Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases.
PubMed:
Bacterial division: the fellowship of the ring.
PubMed:
Isolation and analysis of a protease gene with an ABC transport system in the fish pathogen Yersinia ruckeri: insertional mutagenesis and involvement in virulence.
PubMed:
Mechanistic studies of the astacin-like Serratia metalloendopeptidase serralysin: highly active (>2000%) Co(II) and Cu(II) derivatives for further corroboration of a "metallotriad" mechanism.
PubMed:
Arylamidase activity of neutral proteinase from Saccharomonospora canescens. Comparison with other Zn-proteinases that exhibit the same activity.
PubMed:
Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers.
PubMed:
The conformations of polypeptide chains where the main-chain parts of successive residues are enantiomeric. Their occurrence in cation and anion-binding regions of proteins.
PubMed:
Protease C of Erwinia chrysanthemi: the crystal structure and role of amino acids Y228 and E189.
PubMed:
Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond.
PubMed:
Pathogenesis of Proteus mirabilis urinary tract infection.
PubMed:
Development of an operational substrate for ZapA, a metalloprotease secreted by the bacterium Proteus mirabilis.
PubMed:
[Serralysin Zn-metalloproteinases--structure, function, secretion pathway, and pathogenicity].
PubMed:
Use of a 49-peptide library for a qualitative and quantitative determination of pseudomonal serralysin specificity.
PubMed:
Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases.
PubMed:
Use of liquid chromatography-mass spectrometry coupling for monitoring the serralysin-catalyzed hydrolysis of a peptide library.
PubMed:
Identification of a member of the serralysin family isolated from a psychrotrophic bacterium, Pseudomonas fluorescens 114.
PubMed:
ZapA, the IgA-degrading metalloprotease of Proteus mirabilis, is a virulence factor expressed specifically in swarmer cells.
PubMed:
Specificity of Pseudomonas aeruginosa serralysin revisited, using biologically active peptides as substrates.
PubMed:
Quantitation and enzymatic activity of the alkaline protease from Pseudomonas aeruginosa in culture supernatants from clinical strains.
PubMed:
Kinetic characterization of the serralysins: a divergent catalytic mechanism pertaining to astacin-type metalloproteases.
PubMed:
Activation of human matrix metalloproteinases by various bacterial proteinases.
PubMed:
Purification and characterization of an extracellular metalloprotease from Pseudomonas fluorescens.
PubMed:
Differentiation of thermolysins and serralysins by monoclonal antibodies.
PubMed:
X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.
PubMed:
Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.
PubMed:
Molecular analysis of a metalloprotease from Proteus mirabilis.
PubMed:
Serralysin and related bacterial proteinases.
PubMed:
Families of zinc metalloproteases.