ubiquinol

reduced ubiquinones

CAS: 56275-39-9 C49 H78 O4 MW: 731.15746000

Identification

Nameubiquinol
CAS Number56275-39-9
FDA UNIISearch
Molecular FormulaC49 H78 O4
Molecular Weight731.15746000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 787.45 °C. @ 760.00 mm Hg (est)
Flash Point 806.00 °F. TCC ( 430.00 °C. ) (est)
logP (o/w) 17.372 (est)
Soluble in water, 1.872e-015 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for ubiquinol usage levels up tonot for fragrance use.
Recommendation for ubiquinol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

2,3- dimethoxy-5-methyl-6-[(2E)-7-methylocta-2,6-dienyl]benzene-1,4-diol reduced ubiquinones PubMed: Determination of the coenzyme Q10 status in a large Caucasian study population. PubMed: Dietary restriction decreases coenzyme Q and ubiquinol potentially via changes in gene expression in the model organism C. elegans. PubMed: Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. PubMed: Transcriptome analyses to understand effects of the Fusarium deoxynivalenol and nivalenol mycotoxins on Escherichia coli. PubMed: Enhanced hexose fermentation by Saccharomyces cerevisiae through integration of stoichiometric modeling and genetic screening. PubMed: Promotion of growth by Coenzyme Q10 is linked to gene expression in C. elegans. PubMed: Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. PubMed: Increased bioavailability of ubiquinol compared to that of ubiquinone is due to more efficient micellarization during digestion and greater GSH-dependent uptake and basolateral secretion by Caco-2 cells. PubMed: Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis. PubMed: Ubiquinol improves symptoms in children with autism. PubMed: Long-term Effect of Ubiquinol on Exercise Capacity and the Oxidative Stress Regulation System in SAMP1 Mice. PubMed: Acetic acid bacteria genomes reveal functional traits for adaptation to life in insect guts. PubMed: A comparative study into alterations of coenzyme Q redox status in ageing pigs, mice, and worms. PubMed: Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria. PubMed: Kinetic study of aroxyl radical scavenging and α-tocopheroxyl regeneration rates of pyrroloquinolinequinol (PQQH2, a reduced form of pyrroloquinolinequinone) in dimethyl sulfoxide solution: finding of synergistic effect on the reaction rate due to the coexistence of α-tocopherol and PQQH2. PubMed: Identification and validation of reference genes for gene expression analysis using quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae). PubMed: Effect of ubiquinol-10 on citral stability and off-flavor formation in oil-in-water (O/W) nanoemulsions. PubMed: Increased ubiquinone concentration after intracerebroventricularly-administered ubiquinol to selected rat brain regions. PubMed: Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans. PubMed: Development of singlet oxygen absorption capacity (SOAC) assay method. 3. Measurements of the SOAC values for phenolic antioxidants. PubMed: Respiratory chain analysis of Zymomonas mobilis mutants producing high levels of ethanol. PubMed: Macronutrient-induced differences in food intake relate with hepatic oxidative metabolism and hypothalamic regulatory neuropeptides in rainbow trout (Oncorhynchus mykiss). PubMed: The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells. PubMed: Kinetic study of the quenching reaction of singlet oxygen by Pyrroloquinolinequinol (PQQH(2), a reduced form of Pyrroloquinolinequinone) in micellar solution. PubMed: Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. PubMed: The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. PubMed: Effect of lead toxicity on coenzyme Q levels in rat tissues. PubMed: Nanoliposomes mediate coenzyme Q10 transport and accumulation across human intestinal Caco-2 cell monolayer. PubMed: Effects of ubiquinol-10 on microRNA-146a expression in vitro and in vivo. PubMed: In Vitro Effects of the Reduced Form of Coenzyme Q(10) on Secretion Levels of TNF-alpha and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1. PubMed: Genomic evidence for interspecies acquisition of chromosomal DNA from Campylobacter jejuni by Campylobacter coli strains of a turkey-associated clonal group (cluster II). PubMed: Subchronic oral toxicity of ubiquinol in rats and dogs. PubMed: Identification and characterization of an alternative oxidase in the entomopathogenic fungus Metarhizium anisopliae. PubMed: Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action. PubMed: Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism. PubMed: Dynamics of lipid oxidation and antioxidant depletion in Mediterranean fish stored at different temperatures. PubMed: Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat. PubMed: Effects of diet energy level and tomato powder consumption on antioxidant status in rats. PubMed: Interactions between mitochondrial lipid oxidation and oxymyoglobin oxidation and the effects of vitamin E. PubMed: Pro-oxidative effect of alpha-tocopherol in the oxidation of LDL isolated from co-antioxidant-depleted non-diabetic hemodialysis patients. PubMed: Identification of sigmaB-dependent genes in Bacillus cereus by proteome and in vitro transcription analysis. PubMed: Molecular mechanism of cell death induced by the antioxidant tert-butylhydroxyanisole in human monocytic leukemia U937 cells. PubMed: Ubiquinol:cytochrome c oxidoreductase. Effects of inhibitors on reverse electron transfer from the iron-sulfur protein to cytochrome b. PubMed: The effects of dietary restriction on mitochondrial dysfunction in aging. PubMed: Oxidant defense systems in testes from zinc-deficient rats. PubMed: Dietary antioxidants in disease prevention. PubMed: Mitochondrial cytochrome b gene in two developmental stages of human malarial parasite Plasmodium falciparum. PubMed: Quinones and quinols as inhibitors of lipid peroxidation.