ubiquinol
reduced ubiquinones
Identification
| Name | ubiquinol |
| CAS Number | 56275-39-9 |
| FDA UNII | Search |
| Molecular Formula | C49 H78 O4 |
| Molecular Weight | 731.15746000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 787.45 °C. @ 760.00 mm Hg (est) |
| Flash Point | 806.00 °F. TCC ( 430.00 °C. ) (est) |
| logP (o/w) | 17.372 (est) |
| Soluble in | water, 1.872e-015 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for ubiquinol usage levels up to | not for fragrance use. |
| Recommendation for ubiquinol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2,3-
dimethoxy-5-methyl-6-[(2E)-7-methylocta-2,6-dienyl]benzene-1,4-diol
reduced
ubiquinones
PubMed:
Determination of the coenzyme Q10 status in a large Caucasian study population.
PubMed:
Dietary restriction decreases coenzyme Q and ubiquinol potentially via changes in gene expression in the model organism C. elegans.
PubMed:
Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects.
PubMed:
Transcriptome analyses to understand effects of the Fusarium deoxynivalenol and nivalenol mycotoxins on Escherichia coli.
PubMed:
Enhanced hexose fermentation by Saccharomyces cerevisiae through integration of stoichiometric modeling and genetic screening.
PubMed:
Promotion of growth by Coenzyme Q10 is linked to gene expression in C. elegans.
PubMed:
Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.
PubMed:
Increased bioavailability of ubiquinol compared to that of ubiquinone is due to more efficient micellarization during digestion and greater GSH-dependent uptake and basolateral secretion by Caco-2 cells.
PubMed:
Spatial modulation of key pathway enzymes by DNA-guided scaffold system and respiration chain engineering for improved N-acetylglucosamine production by Bacillus subtilis.
PubMed:
Ubiquinol improves symptoms in children with autism.
PubMed:
Long-term Effect of Ubiquinol on Exercise Capacity and the Oxidative Stress Regulation System in SAMP1 Mice.
PubMed:
Acetic acid bacteria genomes reveal functional traits for adaptation to life in insect guts.
PubMed:
A comparative study into alterations of coenzyme Q redox status in ageing pigs, mice, and worms.
PubMed:
Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria.
PubMed:
Kinetic study of aroxyl radical scavenging and α-tocopheroxyl regeneration rates of pyrroloquinolinequinol (PQQH2, a reduced form of pyrroloquinolinequinone) in dimethyl sulfoxide solution: finding of synergistic effect on the reaction rate due to the coexistence of α-tocopherol and PQQH2.
PubMed:
Identification and validation of reference genes for gene expression analysis using quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae).
PubMed:
Effect of ubiquinol-10 on citral stability and off-flavor formation in oil-in-water (O/W) nanoemulsions.
PubMed:
Increased ubiquinone concentration after intracerebroventricularly-administered ubiquinol to selected rat brain regions.
PubMed:
Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans.
PubMed:
Development of singlet oxygen absorption capacity (SOAC) assay method. 3. Measurements of the SOAC values for phenolic antioxidants.
PubMed:
Respiratory chain analysis of Zymomonas mobilis mutants producing high levels of ethanol.
PubMed:
Macronutrient-induced differences in food intake relate with hepatic oxidative metabolism and hypothalamic regulatory neuropeptides in rainbow trout (Oncorhynchus mykiss).
PubMed:
The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells.
PubMed:
Kinetic study of the quenching reaction of singlet oxygen by Pyrroloquinolinequinol (PQQH(2), a reduced form of Pyrroloquinolinequinone) in micellar solution.
PubMed:
Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans.
PubMed:
The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice.
PubMed:
Effect of lead toxicity on coenzyme Q levels in rat tissues.
PubMed:
Nanoliposomes mediate coenzyme Q10 transport and accumulation across human intestinal Caco-2 cell monolayer.
PubMed:
Effects of ubiquinol-10 on microRNA-146a expression in vitro and in vivo.
PubMed:
In Vitro Effects of the Reduced Form of Coenzyme Q(10) on Secretion Levels of TNF-alpha and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1.
PubMed:
Genomic evidence for interspecies acquisition of chromosomal DNA from Campylobacter jejuni by Campylobacter coli strains of a turkey-associated clonal group (cluster II).
PubMed:
Subchronic oral toxicity of ubiquinol in rats and dogs.
PubMed:
Identification and characterization of an alternative oxidase in the entomopathogenic fungus Metarhizium anisopliae.
PubMed:
Proteome response in HT-29 human colorectal cancer cells to two apoptosis-inducing compounds with different mode of action.
PubMed:
Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism.
PubMed:
Dynamics of lipid oxidation and antioxidant depletion in Mediterranean fish stored at different temperatures.
PubMed:
Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat.
PubMed:
Effects of diet energy level and tomato powder consumption on antioxidant status in rats.
PubMed:
Interactions between mitochondrial lipid oxidation and oxymyoglobin oxidation and the effects of vitamin E.
PubMed:
Pro-oxidative effect of alpha-tocopherol in the oxidation of LDL isolated from co-antioxidant-depleted non-diabetic hemodialysis patients.
PubMed:
Identification of sigmaB-dependent genes in Bacillus cereus by proteome and in vitro transcription analysis.
PubMed:
Molecular mechanism of cell death induced by the antioxidant tert-butylhydroxyanisole in human monocytic leukemia U937 cells.
PubMed:
Ubiquinol:cytochrome c oxidoreductase. Effects of inhibitors on reverse electron transfer from the iron-sulfur protein to cytochrome b.
PubMed:
The effects of dietary restriction on mitochondrial dysfunction in aging.
PubMed:
Oxidant defense systems in testes from zinc-deficient rats.
PubMed:
Dietary antioxidants in disease prevention.
PubMed:
Mitochondrial cytochrome b gene in two developmental stages of human malarial parasite Plasmodium falciparum.
PubMed:
Quinones and quinols as inhibitors of lipid peroxidation.