3-O-acetyl-11-keto-beta-boswellic acid

(3a)-3-acetoxy-11-oxours-12-en-24-oic acid

CAS: 67416-61-9 C32 H48 O5 MW: 512.73056000

Identification

Name3-O-acetyl-11-keto-beta-boswellic acid
CAS Number67416-61-9
FDA UNIIBS16QT99Q1
Molecular FormulaC32 H48 O5
Molecular Weight512.73056000
MDL NumberMFCD03788777
Nikkaji NumberJ38.478J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 600.29 °C. @ 760.00 mm Hg (est)
Flash Point 364.00 °F. TCC ( 184.40 °C. ) (est)
logP (o/w) 7.418 (est)
Soluble in water, 0.0002815 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for 3-O-acetyl-11-keto-beta-boswellic acid usage levels up tonot for fragrance use.
Recommendation for 3-O-acetyl-11-keto-beta-boswellic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

boswellia serrata

Synonyms

(3a)-3- acetoxy-11-oxours-12-en-24-oic acid 3- acetyl-11-keto-beta-boswellic acid (3a)-3-( acetyloxy)-11-oxours-12-en-24-oic acid urs-12-en-24-oic acid, 3-(acetyloxy)-11-oxo-, (3a)- PubMed: 3-O-acetyl-11-keto-?-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase PubMed: 3-O-Acetyl-11-keto- ? -boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma PubMed: A Validated LC-MS/MS Method for Simultaneous Determination of 3-O-Acetyl-11-Keto-?-Boswellic Acid (AKBA) and its Active Metabolite Acetyl-11-Hydroxy-?-Boswellic Acid (Ac-11-OH-BA) in Rat Plasma: Application PubMed: Understanding the role of 3-O-Acetyl-11-keto-?-boswellic acid in conditions of oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity PubMed: Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities PubMed: The major Boswellia serrata active 3-acetyl-11-keto-?-boswellic acid strengthens interleukin-1à upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation PubMed: Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-?-Boswellic Acid and their Cytotoxic Activity PubMed: In silico analysis of aqueous root extract of Rotula aquatica Lour for docking analysis of the compound 3-O-acetyl-11-keto-?-boswellic acid contents PubMed: A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee PubMed: Urease inhibitory activities of ?-boswellic acid derivatives PubMed: Synthesis of new boswellic acid derivatives as potential antiproliferative agents PubMed: Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MS(e) PubMed: Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)) PubMed: Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines PubMed: Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts PubMed: Pharmacological evidences for cytotoxic and antitumor properties of Boswellic acids from Boswellia serrata PubMed: [Effect of acetyl-11-keto-?-boswellic acid on proliferation, apoptosis and cell cycle of human acute myeloid leukemia cell line HL-60] PubMed: Simultaneous quantification of triterpenoic acids by high performance liquid chromatography method in the extracts of gum resin of Boswellia serrata obtained by different extraction techniques PubMed: Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid PubMed: Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues PubMed: Synthesis of new analogs of AKBA and evaluation of their anti-inflammatory activities PubMed: Frankincense ( r? xi?ng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases PubMed: High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb PubMed: Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37 PubMed: Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture PubMed: Quantification of AKBA in Boswellia sacra Using NIRS Coupled with PLSR as an Alternative Method and Cross-Validation by HPLC PubMed: Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro PubMed: In Vivo Osteoinduction: Evaluating 2-Beta Coxatene as an Immunoinductive Compound and Novel Ingredient for Joint Support PubMed: Pharmacokinetics of solid lipid Boswellia serrata particles in healthy subjects PubMed: Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract