4H-1-benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-

CAS: 3681-99-0 C21 H20 O9 MW: 416.38320000

Identification

Namepuerarin
CAS Number3681-99-0
FDA UNIIZ9W8997416
Molecular FormulaC21 H20 O9
Molecular Weight416.38320000
MDL NumberMFCD00076007
Beilstein0064198

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 688.04 °C. @ 760.00 mm Hg (est)
Flash Point 473.00 °F. TCC ( 245.10 °C. ) (est)
logP (o/w) 0.408 (est)
Soluble in water, 8845 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 738 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants
Recommendation for puerarin usage levels up tonot for fragrance use.
Recommendation for puerarin flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Potential Uses

None Found

Natural Occurrence

radix puerariae root

Synonyms

4H-1- benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)- daidzein-8-C-glucoside 8-beta-d- glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-one 7- hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one PubMed: Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. PubMed: A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells. PubMed: Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. PubMed: The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. PubMed: Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. PubMed: Anti-inflammatory effects of total isoflavones from Pueraria lobata on cerebral ischemia in rats. PubMed: Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. PubMed: Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. PubMed: Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. PubMed: Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. PubMed: Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. PubMed: Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. PubMed: Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase. PubMed: Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice. PubMed: Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. PubMed: Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. PubMed: Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase. PubMed: Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. PubMed: The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. PubMed: Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. PubMed: Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes. PubMed: Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids. PubMed: Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. PubMed: Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line. PubMed: Enzymatic synthesis of glycosylated puerarin using maltogenic amylase from Bacillus stearothermophilus expressed in Bacillus subtilis. PubMed: Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. PubMed: Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats. PubMed: [Identification of three-step IR spectra of radix Puerariae from different habitats]. PubMed: Glycosylation of dietary flavonoids decreases the affinities for plasma protein. PubMed: Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root. PubMed: Comparison of flavonoids and isoflavonoids as antioxidants. PubMed: Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. PubMed: Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. PubMed: Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. PubMed: Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. PubMed: Determination of phytoestrogens in dietary supplements by LC-MS/MS. PubMed: Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. PubMed: [Studies on the interaction between puerarin and bovine serum albumin]. PubMed: Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. PubMed: Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. PubMed: Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene. PubMed: Analysis of isoflavones in foods and dietary supplements. PubMed: Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. PubMed: Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments. PubMed: Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. PubMed: Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. PubMed: Human gut microbial degradation of flavonoids: structure-function relationships. PubMed: In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase. PubMed: Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. PubMed: Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. PubMed: Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. PubMed: Plant derivatives in the treatment of alcohol dependency. PubMed: Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. PubMed: Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. PubMed: Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. PubMed: Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. PubMed: Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. PubMed: Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. PubMed: Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. PubMed: Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. PubMed: Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology.