aloe emodin

1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthraquinone

CAS: 481-72-1 C15 H10 O5 MW: 270.24070000

Identification

Namealoe emodin
CAS Number481-72-1
EINECS207-571-7
FDA UNIIC8IYT9CR7C
Molecular FormulaC15 H10 O5
Molecular Weight270.24070000
MDL NumberMFCD00017373
Nikkaji NumberJ5.780K
Beilstein2059062

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 223.50 °C. @ 760.00 mm Hg
Boiling Point 568.82 °C. @ 760.00 mm Hg (est)
Flash Point 593.00 °F. TCC ( 311.90 °C. ) (est)
logP (o/w) 3.254 (est)
Soluble in water, 45.8 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for aloe emodin usage levels up tonot for fragrance use.
Recommendation for aloe emodin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

rhubarb

Synonyms

aloe-emodin aloe-emodine aloeemodin aloeemodin:9,10-Anthracenedione,1,8-dihydroxy-3-(hydroxymethyl)-, 9,10- anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- 9,10- anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- (9CI) anthraquinone, 1,8-dihydroxy-3-hydroxymethyl- 1,8- dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione 1,8- dihydroxy-3-(hydroxymethyl)-9,10-anthraquinone 1,8- dihydroxy-3-(hydroxymethyl)anthra-9,10-quinone 1,8- dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione 1,8- dihydroxy-3-(hydroxymethyl)anthraquinone 1,8- dihydroxy-3-hydroxymethyl-anthraquinone 1,8- dihydroxy-3-hydroxymethylanthraquinone emodine 3- hydroxymethylchrysazine rhabarberone PubMed: Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D. PubMed: Assessment of antibacterial properties and the active ingredient of plant extracts and its effect on the performance of crucian carp (Carassius auratus gibelio var. E'erqisi, Bloch). PubMed: Comment on "The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells by Zhu et al. (2012). PubMed: Cell-type dependent response of melanoma cells to aloe emodin. PubMed: Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis. PubMed: The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells. PubMed: A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode. PubMed: Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models. PubMed: Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. PubMed: Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. PubMed: Anti-angiogenic effects of rhubarb and its anthraquinone derivatives. PubMed: Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice. PubMed: Aloe-emodin-induced apoptosis in human gastric carcinoma cells. PubMed: Chemical constituents of cape aloe and their synergistic growth-inhibiting effect on Ehrlich ascites tumor cells. PubMed: Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography. PubMed: Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. PubMed: Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2). PubMed: Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungi. PubMed: Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. PubMed: In vitro studies on the photobiological properties of aloe emodin and aloin A. PubMed: [Contents of barbaloin-related compounds in aloe drinks and their change during storage]. PubMed: Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated?