dihydroartemisinin
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
Identification
| Name | dihydroartemisinin |
| CAS Number | 81496-82-4 |
| FDA UNII | 6A9O50735X |
| Molecular Formula | C15 H24 O5 |
| Molecular Weight | 284.35228000 |
| MDL Number | MFCD00274495 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 375.62 °C. @ 760.00 mm Hg (est) |
| Flash Point | 358.00 °F. TCC ( 181.00 °C. ) (est) |
| logP (o/w) | 2.190 (est) |
| Soluble in | water, 659.9 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for dihydroartemisinin usage levels up to | not for fragrance use. |
| Recommendation for dihydroartemisinin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
dihxdroarteannui
dihydroartemisinine
dihyroartemisinin
3,12-
epoxy-12-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (5aS,6R,8aS,9R,10S,12R,12aR)-
3,12-
epoxy-12H-yrano(4,3-j)-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
3,12-
epoxy-12H-yrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
1,5,9-
trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-
trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
(4S,5R,8S,9R,10S,12R,13R)-1,5,9-
trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-
trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-
trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-ol
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Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish.
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Management of imported malaria in Europe.
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Malaria: severe, life-threatening.
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Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects.
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Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.
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Effects of dihydroartemisinin on fine structure of erythrocytic stages of Plasmodium berghei ANKA strain.
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