hirudin
L-glutamine, glycyl-D-a-aspartyl-L-phenylalanyl-L-a-glutamyl-L-a-glutamyl-L-alloisoleucyl-L-prolyl-D-a-glutamyl-L-a-glutamyl-L-tyrosyl-L-leucyl-
Identification
| Name | hirudin |
| CAS Number | 113274-56-9 |
| FDA UNII | Search |
| Molecular Formula | C66 H93 N13 O25 |
| Molecular Weight | 1468.53821000 |
| Nikkaji Number | J378.864D |
Regulatory
Physical Properties
| Appearance | white fine powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 1913.60 °C. @ 760.00 mm Hg (est) |
| Flash Point | 2032.00 °F. TCC ( 1111.10 °C. ) (est) |
| logP (o/w) | -0.190 (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for hirudin usage levels up to | not for fragrance use. |
| Recommendation for hirudin flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
L-
glutamine, glycyl-D-a-aspartyl-L-phenylalanyl-L-a-glutamyl-L-a-glutamyl-L-alloisoleucyl-L-prolyl-D-a-glutamyl-L-a-glutamyl-L-tyrosyl-L-leucyl-
glycyl-D-a-aspartyl-L-phenylalanyl-L-a-glutamyl-L-a-glutamyl-L-alloisoleucyl-L-prolyl-D-a-glutamyl-L-a-glutamyl-L-tyrosyl-L-leucyl-L-glutamine
PubMed:
Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays.
PubMed:
New oral anticoagulants: comparative pharmacology with vitamin K antagonists.
PubMed:
Use of oil bodies and oleosins in recombinant protein production and other biotechnological applications.
PubMed:
Brave new world: the current and future use of novel anticoagulants.
PubMed:
Expression and intein-mediated purification of novel staphylokinase SakSTAR with reduced immunogenicity and antiplatelet and antithrombin activation.
PubMed:
Novel method of expression and purification of hirudin based on pBAD TOPO, pTYB12 vectors and gene synthesis.
PubMed:
Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy.
PubMed:
Current anticoagulant therapy--unmet clinical needs.
PubMed:
Coexpression of BiP increased antithrombotic hirudin production in recombinant Saccharomyces cerevisiae.
PubMed:
Selective inhibition of coagulation factors: advances in antithrombotic therapy.
PubMed:
New drugs 2002. Part II.
PubMed:
Bivalirudin: a direct thrombin inhibitor.
PubMed:
Current status of the anticoagulant hirudin: its biotechnological production and clinical practice.
PubMed:
Cardiovascular drug highlight: hirudin.
PubMed:
Use of recombinant hirudin in heparin-induced thrombocytopenia and thrombosis (HITT) and renal failure--a case report.
PubMed:
Effects of methanol on expression of an anticoagulant hirudin in recombinant Hansenula polymorpha.
PubMed:
From the Food and Drug Administration.
PubMed:
Enhanced production of anticoagulant hirudin in recombinant Saccharomyces cerevisiae by chromosomal delta-integration.
PubMed:
FDA panel votes against approval for bivalirudin.
PubMed:
Therapy for patients with heparin-induced thrombocytopenia marketed.
PubMed:
Separation of r-hirudin from similar substances by capillary electrophoresis.