chelerythrine
[1,3]benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-
Identification
| Name | chelerythrine |
| CAS Number | 34316-15-9 |
| EINECS | 251-930-0 |
| FDA UNII | E3B045W6X0 |
| Molecular Formula | C21 H18 N O4 |
| Molecular Weight | 348.37826000 |
| Nikkaji Number | J19.428J |
Regulatory
Physical Properties
| Appearance | brown powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -0.401 (est) |
| Soluble in | water, 6.03 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for chelerythrine usage levels up to | not for fragrance use. |
| Recommendation for chelerythrine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
[1,3]
benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-
1,2-
dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
1,2-
dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium
1,2-
dimethoxy-12-methyl-[1,3]dioxolo[4'',5'':4,5]benzo[1,2-c]phenanthridin-12-ium
1,2-
dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium
1,2-
dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
1,2-
dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium
1,2-
dimethoxy-12-methyl[1,3]dioxolo[4,5]benzo[1,2-c]phenanthridin-12-ium
toddalin
toddaline
PubMed:
In vitro and in vivo investigations on the antitumour activity of Chelidonium majus.
PubMed:
Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus.
PubMed:
Partial effects of the protein kinase C inhibitor chelerythrine in a battery of tests for manic-like behavior in black Swiss mice.
PubMed:
Antihyperglycemic action of sinapic acid in diabetic rats.
PubMed:
TNFα regulates sugar transporters in the human intestinal epithelial cell line Caco-2.
PubMed:
Integration of transcriptome, proteome and metabolism data reveals the alkaloids biosynthesis in Macleaya cordata and Macleaya microcarpa.
PubMed:
Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory.
PubMed:
Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.
PubMed:
Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury.
PubMed:
Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).
PubMed:
Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: analyses in rat hepatoma cell line H4IIE.luc.
PubMed:
Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.
PubMed:
Mechanisms underlying anorexia after microinjection of bombesin into the lateral cerebroventricle.
PubMed:
Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.
PubMed:
Effects of leptin on hypothalamic arcuate neurons in Wistar and Zucker rats: an in vitro study.
PubMed:
Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats.
PubMed:
Involvement of protein kinase C and tyrosine kinase in lipopolysaccharide-induced anorexia.