chelerythrine

[1,3]benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-

CAS: 34316-15-9 C21 H18 N O4 MW: 348.37826000

Identification

Namechelerythrine
CAS Number34316-15-9
EINECS251-930-0
FDA UNIIE3B045W6X0
Molecular FormulaC21 H18 N O4
Molecular Weight348.37826000
Nikkaji NumberJ19.428J

Regulatory

Physical Properties

Appearance brown powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -0.401 (est)
Soluble in water, 6.03 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for chelerythrine usage levels up tonot for fragrance use.
Recommendation for chelerythrine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

celandine greater celandine

Synonyms

[1,3] benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl- 1,2- dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium 1,2- dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium 1,2- dimethoxy-12-methyl-[1,3]dioxolo[4'',5'':4,5]benzo[1,2-c]phenanthridin-12-ium 1,2- dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium 1,2- dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium 1,2- dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium 1,2- dimethoxy-12-methyl[1,3]dioxolo[4,5]benzo[1,2-c]phenanthridin-12-ium toddalin toddaline PubMed: In vitro and in vivo investigations on the antitumour activity of Chelidonium majus. PubMed: Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus. PubMed: Partial effects of the protein kinase C inhibitor chelerythrine in a battery of tests for manic-like behavior in black Swiss mice. PubMed: Antihyperglycemic action of sinapic acid in diabetic rats. PubMed: TNFα regulates sugar transporters in the human intestinal epithelial cell line Caco-2. PubMed: Integration of transcriptome, proteome and metabolism data reveals the alkaloids biosynthesis in Macleaya cordata and Macleaya microcarpa. PubMed: Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. PubMed: Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment. PubMed: Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury. PubMed: Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.). PubMed: Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: analyses in rat hepatoma cell line H4IIE.luc. PubMed: Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells. PubMed: Mechanisms underlying anorexia after microinjection of bombesin into the lateral cerebroventricle. PubMed: Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment. PubMed: Effects of leptin on hypothalamic arcuate neurons in Wistar and Zucker rats: an in vitro study. PubMed: Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats. PubMed: Involvement of protein kinase C and tyrosine kinase in lipopolysaccharide-induced anorexia.