tanshinone

phenanthro[1,2-b]furan-10,11-dione, 1,6-dimethyl-

CAS: 568-73-0 C18 H12 O3 MW: 276.29124000

Identification

Nametanshinone
CAS Number568-73-0
FDA UNII03UUH3J385
Molecular FormulaC18 H12 O3
Molecular Weight276.29124000
MDL NumberMFCD00210563
Nikkaji NumberJ12.294G

Regulatory

Physical Properties

Appearance red-brown powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 497.96 °C. @ 760.00 mm Hg (est)
Flash Point 475.00 °F. TCC ( 245.90 °C. ) (est)
logP (o/w) 4.312 (est)
Soluble in water, 0.04758 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for tanshinone usage levels up tonot for fragrance use.
Recommendation for tanshinone flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1,6- dimethyl-phenanthro[1,2-b]furan-10,11-dione 1,6- dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione 1,6- dimethylphenanthro(1,2-b)furan-10,11-dione 1,6- dimethylphenanthro[1,2-b]furan-10,11-dione phenanthro(1,2-b)furan-10,11-dione, 1,6-dimethyl- phenanthro[1,2-b]furan-10,11-dione, 1,6-dimethyl- tanshinon I tanshinone I tanshinone II B tanshinone IIB PubMed: Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism. PubMed: A novel 9 × 9 map-based solvent selection strategy for targeted counter-current chromatography isolation of natural products. PubMed: Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I. PubMed: Dispersive micro-solid-phase extraction using mesoporous hybrid materials for simultaneous determination of semivolatile compounds from plant tea by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. PubMed: Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae. PubMed: Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity. PubMed: The profiling of bioactive ingredients of differently aged Salvia miltiorrhiza roots. PubMed: Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: in vitro and in vivo evaluation. PubMed: Tanshinone IIA improves endoplasmic reticulum stress-induced insulin resistance through AMP-activated protein kinase. PubMed: [Chemical constituents contained in Salvia castanea]. PubMed: Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. PubMed: Extraction and concentration of tanshinones in Salvia miltiorrhiza Bunge by task-specific non-ionic surfactant assistance. PubMed: Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants. PubMed: Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. PubMed: Genetic stability, active constituent, and pharmacoactivity of Salvia miltiorrhiza hairy roots and wild plant. PubMed: Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo. PubMed: Chemical characteristics of Salvia miltiorrhiza (Danshen) collected from different locations in China. PubMed: Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: synthesis and cytotoxicity evaluation. PubMed: Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo. PubMed: The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. PubMed: Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge. PubMed: Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design. PubMed: Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster. PubMed: Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation. PubMed: PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.