tanshinone
phenanthro[1,2-b]furan-10,11-dione, 1,6-dimethyl-
Identification
| Name | tanshinone |
| CAS Number | 568-73-0 |
| FDA UNII | 03UUH3J385 |
| Molecular Formula | C18 H12 O3 |
| Molecular Weight | 276.29124000 |
| MDL Number | MFCD00210563 |
| Nikkaji Number | J12.294G |
Regulatory
Physical Properties
| Appearance | red-brown powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 497.96 °C. @ 760.00 mm Hg (est) |
| Flash Point | 475.00 °F. TCC ( 245.90 °C. ) (est) |
| logP (o/w) | 4.312 (est) |
| Soluble in | water, 0.04758 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for tanshinone usage levels up to | not for fragrance use. |
| Recommendation for tanshinone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,6-
dimethyl-phenanthro[1,2-b]furan-10,11-dione
1,6-
dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
1,6-
dimethylphenanthro(1,2-b)furan-10,11-dione
1,6-
dimethylphenanthro[1,2-b]furan-10,11-dione
phenanthro(1,2-b)furan-10,11-dione, 1,6-dimethyl-
phenanthro[1,2-b]furan-10,11-dione, 1,6-dimethyl-
tanshinon I
tanshinone I
tanshinone II B
tanshinone IIB
PubMed:
Dan-Qi prescription ameliorates insulin resistance through overall corrective regulation of glucose and fat metabolism.
PubMed:
A novel 9 Ã 9 map-based solvent selection strategy for targeted counter-current chromatography isolation of natural products.
PubMed:
Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I.
PubMed:
Dispersive micro-solid-phase extraction using mesoporous hybrid materials for simultaneous determination of semivolatile compounds from plant tea by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
PubMed:
Tanshinones extend chronological lifespan in budding yeast Saccharomyces cerevisiae.
PubMed:
Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity.
PubMed:
The profiling of bioactive ingredients of differently aged Salvia miltiorrhiza roots.
PubMed:
Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: in vitro and in vivo evaluation.
PubMed:
Tanshinone IIA improves endoplasmic reticulum stress-induced insulin resistance through AMP-activated protein kinase.
PubMed:
[Chemical constituents contained in Salvia castanea].
PubMed:
Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function.
PubMed:
Extraction and concentration of tanshinones in Salvia miltiorrhiza Bunge by task-specific non-ionic surfactant assistance.
PubMed:
Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants.
PubMed:
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.
PubMed:
Genetic stability, active constituent, and pharmacoactivity of Salvia miltiorrhiza hairy roots and wild plant.
PubMed:
Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo.
PubMed:
Chemical characteristics of Salvia miltiorrhiza (Danshen) collected from different locations in China.
PubMed:
Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: synthesis and cytotoxicity evaluation.
PubMed:
Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.
PubMed:
The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism.
PubMed:
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.
PubMed:
Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design.
PubMed:
Comparative genotoxicity evaluation of imidazolinone herbicides in somatic cells of Drosophila melanogaster.
PubMed:
Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.
PubMed:
PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation.