ceramide 3

octadecanamide, N-(1,3,4-trihydroxy-2-octadecyl)- (ceramide 3)

CAS: 100403-19-8 C36 H71 N O3 MW: 565.96647000

Identification

Nameceramide 3
CAS Number100403-19-8
EINECS309-560-3
FDA UNII4370DF050B
Molecular FormulaC36 H71 N O3
Molecular Weight565.96647000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 694.52 °C. @ 760.00 mm Hg (est)
Flash Point 705.00 °F. TCC ( 373.80 °C. ) (est)
logP (o/w) 13.577 (est)
Soluble in water, 1.111e-009 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for ceramide 3 usage levels up tonot for fragrance use.
Recommendation for ceramide 3 flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

View All Website (800) 238-0001 info@aicma.com

BOC Sciences

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Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(2S,3R,4E)-2- acylamino-1,3-octadec-4-enediol (ceramide 3) (2S,3R,4E)-2- acylaminooctadec-4-ene-1,3-diol (ceramide 3) ceramide (d18:1/18:0) N-[(2S,3R,4E)-1,3- dihydroxyoctadec-4-en-2-yl]octadecanamide (ceramide 3) N-[(E,2S,3R)-1,3- dihydroxyoctadec-4-en-2-yl]octadecanamide (ceramide 3) N-[(1S,2R,3E)-2- hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-octadecanamide (ceramide 3) octadecanamide, N-(1,3,4-trihydroxy-2-octadecyl)- (ceramide 3) octadecanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]- (ceramide 3) orgasol restore PubMed: A pilot study investigating the efficacy of botanical anti-inflammatory agents in an OTC eczema therapy. PubMed: Safety and risk assessment of ceramide 3 in cosmetic products. PubMed: Identification of the Molecular and Genetic Basis of PX2, a Glycosphingolipid Blood Group Antigen Lacking on Globoside-deficient Erythrocytes. PubMed: Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas). PubMed: Characterizing the composition of underarm and forearm skin using confocal raman spectroscopy. PubMed: Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice. PubMed: Respiratory and cutaneous water loss of temperate-zone passerine birds. PubMed: FTIR spectroscopic analyses of the temperature and pH influences on stratum corneum lipid phase behaviors and interactions. PubMed: Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. PubMed: Isolation and structure of a monomethylated ganglioside possessing neuritogenic activity from the ovary of the sea urchin Diadema setosum. PubMed: Lipids and skin barrier function--a clinical perspective. PubMed: Inhibition of suicidal erythrocyte death by nitric oxide. PubMed: Effect of ceramide on the contractility of pregnant rat uterus. PubMed: Synthesis of 7-oxasphingosine and -ceramide analogues and their evaluation in a model for apoptosis. PubMed: Novel synthesis of alpha-galactosyl-ceramides and confirmation of their powerful NKT cell agonist activity. PubMed: Constituents of Holothuroidea, 17. Isolation and structure of biologically active monosialo-gangliosides from the sea cucumber Cucumaria echinata. PubMed: Structural organisation and phase behaviour of a stratum corneum lipid analogue: ceramide 3A. PubMed: Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema--an in vivo study. PubMed: Substrate specificity of human ceramide kinase. PubMed: ATR-FTIR spectroscopy: a chemometric approach for studying the lipid organisation of the stratum corneum. PubMed: Polymorphism of ceramide 3. Part 2: a vibrational spectroscopic and X-ray powder diffraction investigation of N-octadecanoyl phytosphingosine and the analogous specifically deuterated d(35) derivative. PubMed: Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines. PubMed: Polymorphism of ceramide 3. Part 1: an investigation focused on the head group of N-octadecanoylphytosphingosine. PubMed: Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction. PubMed: Deficiency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. PubMed: Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. PubMed: Constituents of ophiuroidea. 1. Isolation and structure of three ganglioside molecular species from the brittle star Ophiocoma scolopendrina. PubMed: Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study. PubMed: Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures. PubMed: Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase. PubMed: Mouse anti-ceramide antiserum: a specific tool for the detection of endogenous ceramide. PubMed: Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and ceramide. PubMed: Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. PubMed: Constituents of holothuroidea. 10. Isolation and structure of a biologically active ganglioside molecular species from the sea cucumber Holothuria leucospilota. PubMed: X-ray diffraction study on ordered, disordered and reconstituted intercellular lipid lamellar structure in stratum corneum. PubMed: Preparation of liposomes containing Ceramide 3 and their membrane characteristics. PubMed: Structure-related aspects on water diffusivity in fatty acid-soap and skin lipid model systems. PubMed: Indications for an active process underlying spontaneous and radiation-induced micronucleation in L929 cells. PubMed: Stratum corneum lipid composition and structure in cultured skin substitutes is restored to normal after grafting onto athymic mice. PubMed: Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. PubMed: Studies on selectin blockers. 4. Structure-function relationships of sulfated sialyl Lewis X hexasaccharide ceramides toward E-, P-, and L-selectin binding. PubMed: Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. PubMed: Synthesis of neoglycolipids containing a mucin-type core unit. PubMed: Age- and sex-dependent change in stratum corneum sphingolipids. PubMed: Sphingolipid metabolism in organotypic mouse keratinocyte cultures. PubMed: New ganglioside analogs that inhibit influenza virus sialidase. PubMed: Sialidase activities of cultured human fibroblasts and the metabolism of GM3 ganglioside. PubMed: Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype. PubMed: Properties of immunotoxins against a glycolipid antigen associated with Burkitt's lymphoma. PubMed: Ultrastructural and biochemical liver analyses in Fabry's disease. PubMed: Characterization of glycosphingolipids by direct inlet chemical ionization mass spectrometry. PubMed: Glycolipids in human lung carcinoma of histologically different types. PubMed: [Study on glycolipids in human lung carcinoma of histologically different types (author's transl)]. PubMed: Factors affecting the hydrolysis of ceramide-3 by alpha-galactosidase A from human liver. PubMed: Properties of immobilized fig alpha-galactosidase and effect on ceramide-3 content of plasma from patients with Fabry's disease. PubMed: Effect of detergents on ceramide-3 hydrolysis by alpha-galactosidase A.