salinomycin

kokcisan

CAS: 53003-10-4 C42 H70 O11 MW: 751.01110000

Identification

Namesalinomycin
CAS Number53003-10-4
EINECS258-290-1
FDA UNII62UXS86T64
Molecular FormulaC42 H70 O11
Molecular Weight751.01110000

Regulatory

Physical Properties

Appearance white crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 113.00 °C. @ 760.00 mm Hg
Boiling Point 839.16 °C. @ 760.00 mm Hg (est)
Flash Point 470.00 °F. TCC ( 243.20 °C. ) (est)
logP (o/w) 5.596 (est)
Soluble in water, 2.079e-006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 7 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for salinomycin usage levels up tonot for fragrance use.
Recommendation for salinomycin flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

OQEMA

With a focus on providing the highest level of service

OQEMA has established itself at the forefront of the global chemical industry.

View All Website +1 973 886 3778 fandf@oqema.co.uk

Potential Uses

None Found

Natural Occurrence

streptomyces albus PMC

Synonyms

bio-cox coxistac kokcisan salinomicina salinomycine salinomycinum PubMed: Sample treatment platform using nanoparticles to determine salinomycin in flesh and meat. PubMed: Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. PubMed: Salinomycin, a polyether ionophoric antibiotic, inhibits adipogenesis. PubMed: Comparison of the oral bioavailability and tissue disposition of monensin and salinomycin in chickens and turkeys. PubMed: Dietary nisin modulates the gastrointestinal microbial ecology and enhances growth performance of the broiler chickens. PubMed: Development of an ELISA for salinomycin and depletion kinetics of salinomycin residues in poultry. PubMed: Effects of salinomycin on ruminal characteristics and performance of grazing beef steers. PubMed: Effect of salinomycin level on nutrient digestibility and ruminal characteristics of sheep and feedlot performance of cattle. PubMed: Rapid method for the simultaneous determination of six ionophores in feed by liquid chromatography/mass spectrometry. PubMed: Impact of salinomycin on the intestinal microflora of broiler chickens. PubMed: Effect of salinomycin on giardiasis and coccidiosis in growing lambs. PubMed: Effects of orally administered chemotherapeutics (quinine, salinomycin) against Henneguya sp. Thelohán, 1892 (Myxozoa: Myxobolidae), a gill parasite in the tapir fish Gnathonemus petersii Günther, 1862 (Teleostei). PubMed: Microwave extraction of incurred salinomycin from chicken tissues. PubMed: Salinomycin poisoning in point-of-lay turkeys. PubMed: Development and validation of a multiresidue liquid chromatography/tandem mass spectrometry method for 11 coccidiostats in feed. PubMed: Residue control of coccidiostats in food of animal origin in Poland during 2007-2010. PubMed: In vivo screening of four phytochemicals/extracts and a fungal immunomodulatory protein against an Eimeria acervulina infection in broilers. PubMed: Concentrations of salinomycin in eggs and tissues of laying chickens fed medicated feed for 14 days followed by withdrawal for 3 days. PubMed: Risk assessment of coccidostatics during feed cross-contamination: animal and human health aspects. PubMed: Comparison of microwave assisted extraction with conventional (homogenization, vortexing) for the determination of incurred salinomycin in chicken eggs and tissues. PubMed: Rapid time-resolved fluoroimmunoassay for the screening of narasin and salinomycin residues in poultry and eggs. PubMed: Comparative effect of salinomycin and monensin on Streptococcus bovis strain ATCC 9809. PubMed: Determination of the ionophoric coccidiostats narasin, monensin, lasalocid and salinomycin in eggs by liquid chromatography/tandem mass spectrometry. PubMed: Susceptibility of Clostridium difficile toward antimicrobial agents used as feed additives for food animals. PubMed: A case of salinomycin intoxication in turkeys. PubMed: Salinomycin-induced polyneuropathy in cats: morphologic and epidemiologic data. PubMed: The effect of flavophospholipol (Flavomycin) and salinomycin sodium (Sacox) on the excretion of Clostridium perfringens, Salmonella enteritidis, and Campylobacter jejuni in broilers after experimental infection. PubMed: Trace level determination of polyether ionophores in feed. PubMed: Salinomycin toxicosis in horses. PubMed: The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of female broilers: influence of a high-proline diet supplemented with ascorbic acid and zinc. PubMed: The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of broilers. PubMed: [Tiamulin and salinomycin intolerance in swine]. PubMed: Comparison of virginiamycin and salinomycin as growth promoters in growing-fattening pigs. PubMed: Determination of monensin, narasin, and salinomycin in mineral premixes, supplements, and animal feeds by liquid chromatography and post-column derivatization: collaborative study. PubMed: Salinomycin poisoning in veal calves. PubMed: Detection and quantitative analysis of 21 veterinary drugs in river water using high-pressure liquid chromatography coupled to tandem mass spectrometry. PubMed: Single-laboratory validation of a multiplex flow cytometric immunoassay for the simultaneous detection of coccidiostats in eggs and feed. PubMed: Can the use of coccidiostats in poultry breeding lead to residues in vegetables? An experimental study. PubMed: Determination of ionophores in the tissues of food animals by liquid chromatography. PubMed: Determination of 20 coccidiostats in milk, duck muscle and non-avian muscle tissue using UHPLC-MS/MS. PubMed: Development of a five-plex flow cytometric immunoassay for the simultaneous detection of six coccidiostats in feed and eggs. PubMed: The determination of six ionophore coccidiostats in feed by liquid chromatography with postcolumn derivatisation and spectrofotometric/fluorescence detection. PubMed: Residues of veterinary medicinal products and coccidiostats in eggs--causes, control and results of surveillance program in Poland. PubMed: Ionophores: their use as ruminant growth promotants and impact on food safety. PubMed: Occurrence, selection and spread of resistance to antimicrobial agents used for growth promotion for food animals in Denmark. PubMed: Fatty acid composition and oxidative stability of breast meat from broiler chickens supplemented with Moringa oleifera leaf meal over a period of refrigeration. PubMed: The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model. PubMed: Development and validation of an UPLC-MS/MS method for the determination of ionophoric and synthetic coccidiostats in vegetables. PubMed: Antimicrobial susceptibilities of Listeria monocytogenes isolated in Japan. PubMed: Multiple-antibiotic resistance of Enterococcus faecalis and Enterococcus faecium from cecal contents in broiler chicken and turkey flocks slaughtered in Canada and plasmid colocalization of tetO and ermB genes. PubMed: Anticoccidial effects of coumestans from Eclipta alba for sustainable control of Eimeria tenella parasitosis in poultry production. PubMed: Surveillance of antimicrobial resistance in bacteria isolated from food animals to antimicrobial growth promoters and related therapeutic agents in Denmark. PubMed: Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of eleven coccidiostats in milk. PubMed: Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus. PubMed: Monoclonal antibody production and immunochemical detection of polyether antibiotics. PubMed: A new approach to the analysis of nicarbazin and ionophores in eggs by HPLC/MS/MS. PubMed: Selection of single chain variable fragment (scFv) antibodies from a hyperimmunized phage display library for the detection of the antibiotic monensin. PubMed: Determination of ionophore coccidiostats in feeding stuffs by liquid chromatography-tandem mass spectrometry. Part II. Application to cross-contamination levels and non-targeted feed. PubMed: Effect of avoparcin interaction with anticoccidial compounds on the growth and carcase composition of broilers. PubMed: Effect of ionophore antibiotics on experimentally induced lactic acidosis in cattle. PubMed: Ionophore residues in eggs in Northern Ireland: incidence and cause. PubMed: Development and validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for eleven coccidiostats in eggs. PubMed: Pilot survey of hen eggs consumed in the metropolitan area of Rio de Janeiro, Brazil, for polyether ionophores, macrolides and lincosamides residues. PubMed: Effects of coccidiostats and dietary protein on performance and water consumption in broiler chickens. PubMed: [Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals]. PubMed: Incidence of residues of nine anticoccidials in eggs. PubMed: Control of proliferative enteropathy in growing/fattening pigs using growth promoters. PubMed: Evaluation of an improved floor pen model for severe coccidiosis. PubMed: In vitro lactic acid inhibition and alterations in volatile fatty acid production by antimicrobial feed additives. PubMed: Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates. PubMed: Simultaneous determination of four coccidiostats in eggs and broiler meat: validation of an LC-MS/MS method. PubMed: Diversity and susceptibility of Enterococcus isolated from cattle before and after harvest. PubMed: The effect of polyether, ionophorous anticoccidial drugs on feather growth in genetically slow-feathering broilers. PubMed: LC/MS confirmation of ionophores in animal feeds. PubMed: [Effects of veterinary drugs on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)]. PubMed: Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS. PubMed: Potentiometric determination of polyether ionophores growth promotors in animal feed preparations. PubMed: Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials. PubMed: MALDI-TOF MS quantification of coccidiostats in poultry feeds. PubMed: Efficacy of some anticoccidial drugs for treating coccidial enteritis of the common carp caused by Goussia carpelli (Apicomplexa: Eimeriidae). PubMed: Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faecium from broilers and pigs in Denmark, Finland, and Norway. PubMed: [Effect of anticoccidial preparations in the prevention of coccidiosis in turkeys caused by Eimeria adenoides]. PubMed: Prevalence and antimicrobial resistance of enterococci isolated from retail fruits, vegetables, and meats. PubMed: Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria. PubMed: Liquid chromatographic determination of monensin in premix and animal feeds: collaborative study. PubMed: Feed additives and contaminants as a cause of equine disease. PubMed: [Preliminary results of antibiotic resistance monitoring in the Netherlands]. PubMed: Development of an ELISA for lasalocid and depletion kinetics of lasalocid residues in poultry. PubMed: An unaddressed issue of agricultural terrorism: a case study on feed security. PubMed: The influence of nutrient density of broiler rations on the effective dose of anticoccidial drugs. PubMed: Ionophore toxicity in turkey breeders. PubMed: [Growth stimulating effect of salinomycine in breeding and fattening of pigs (author's transl)]. PubMed: Chromatographic analysis of banned antibacterial growth promoters in animal feed. PubMed: A new method for in vitro detection of microbially produced mitochondrial toxins. PubMed: Efficient and sensitive screening and confirmation of residues of selected polyether ionophore antibiotics in liver and eggs by liquid chromatography-electrospray tandem mass spectrometry. PubMed: Development of an ELISA for maduramicin and determination of the depletion kinetics of maduramicin residues in poultry. PubMed: Improved agar diffusion method for detecting residual antimicrobial agents. PubMed: Anticoccidials and turkeys. PubMed: Mitigating the effects of halofuginone on skin strength by feeding L-proline to broiler chickens. PubMed: Development of multiclass methods for drug residues in eggs: silica SPE cleanup and LC-MS/MS analysis of ionophore and macrolide residues. PubMed: An integrated sample preparation to determine coccidiostats and emerging Fusarium-mycotoxins in various poultry tissues with LC-MS/MS. PubMed: Microbial community composition of the ileum and cecum of broiler chickens as revealed by molecular and culture-based techniques. PubMed: Antimicrobial susceptibilities of Staphylococcus aureus isolated from commercial broilers in northeastern Georgia.