cyproconazole

2-(4-chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazolyl)butan-2-ol

CAS: 94361-06-5 C15 H18 Cl N3 O MW: 291.78066000

Identification

Namecyproconazole
CAS Number94361-06-5
FDA UNII622B9C3E6T
Molecular FormulaC15 H18 Cl N3 O
Molecular Weight291.78066000
MDL NumberMFCD01678672
Nikkaji NumberJ633.729E
Beilstein8396421
XlogP32.90 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 107.50 °C. @ 760.00 mm Hg
Boiling Point 479.13 °C. @ 760.00 mm Hg (est)
Vapor Pressure 2.590000 mmHg @ 25.00 °C. (est)
Flash Point 470.00 °F. TCC ( 243.60 °C. ) (est)
logP (o/w) 2.900
Soluble in water, 140 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-mouse LD50 352 mg/kg
Dermal Toxicityskin-rat LD50 > 2000 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 5650 mg/m3/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for cyproconazole usage levels up tonot for fragrance use.
Recommendation for cyproconazole flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

atemi C 2-(4- chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazol-1-yl)butan-2-ol 2-(4- chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazolyl)butan-2-ol 2-(4- chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol (2RS,3RS)-2-(4- chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 2-(4- chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 1H-1,2,4- triazole-1-ethanol, a-(4-chlorophenyl)-a-(1-cyclopropylethyl)- PubMed: Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery. PubMed: Pathogenesis-Related Protein Expression in the Apoplast of Wheat Leaves Protected Against Leaf Rust Following Application of Plant Extracts. PubMed: Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice. PubMed: Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides. PubMed: Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. PubMed: Dynamics and mitigation of six pesticides in a "Wet" forest buffer zone. PubMed: Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola. PubMed: Effects of mixtures of azole fungicides in postimplantation rat whole-embryo cultures. PubMed: Direct enantioseparation of nitrogen-heterocyclic pesticides on amylose-tris-(5-chloro-2-methylphenylcarbamate) by reversed-phase high-performance liquid chromatography. PubMed: Triazole induced concentration-related gene signatures in rat whole embryo culture. PubMed: Triazole-induced gene expression changes in the zebrafish embryo. PubMed: HPLC-MS/MS enantioseparation of triazole fungicides using polysaccharide-based stationary phases. PubMed: Toxicity assessment of 45 pesticides to the epigeic earthworm Eisenia fetida. PubMed: Residues behavior of some fungicides applied on two greenhouse tomato varieties different in shape and weight. PubMed: The hepatocarcinogenic conazoles: cyproconazole, epoxiconazole, and propiconazole induce a common set of toxicological and transcriptional responses. PubMed: Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). PubMed: Environmental fate of fungicides in surface waters of a horticultural-production catchment in southeastern Australia. PubMed: Is the amphibian X. laevis WEC a good alternative method to rodent WEC teratogenicity assay? The example of the three triazole derivative fungicides Triadimefon, Tebuconazole, Cyproconazole. PubMed: Determination of azoles in sewage sludge from Spanish wastewater treatment plants by liquid chromatography-tandem mass spectrometry. PubMed: Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles. PubMed: Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies. PubMed: Fungicide dissipation and impact on metolachlor aerobic soil degradation and soil microbial dynamics. PubMed: Occurrence and removal of fungicides in municipal sewage treatment plant. PubMed: Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD-modified MEKC. PubMed: In vitro toxicity of selected fungicides from the groups of benzimidazoles and demethylation inhibitors to Cladobotryum dendroides and Agaricus bisporus. PubMed: The effect of fungicides on seed yield and disease control in Italian ryegrass. PubMed: Development of monoclonal immunoassays for the determination of triazole fungicides in fruit juices. PubMed: The toxicity study of a systemic fungicide: artea 330 EC on the physiology and the respiratory metabolism of the tadpole (Rana saharica). PubMed: Photocatalytic degradation of pesticides in pure water and a commercial agricultural solution on TiO2 coated media. PubMed: [Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates]. PubMed: Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. PubMed: Control of Mycosphaerella graminicola on wheat seedlings by medical drugs known to modulate the activity of ATP-binding cassette transporters. PubMed: Capabilities of different liquid chromatography tandem mass spectrometry systems in determining pesticide residues in food. Application to estimate their daily intake. PubMed: Sexual reproduction facilitates the adaptation of parasites to antagonistic host environments: Evidence from empirical study in the wheat-Mycosphaerella graminicola system. PubMed: Use of SPE-GC/EIMS for residue analysis in wine elaborated from musts spiked with formulations of chlorpyriphos-methyl, methiocarb, dicofol, and cyproconazol. PubMed: Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.). PubMed: Testing estrogenicity of known and novel (xeno-)estrogens in the MolDarT using developing zebrafish (Danio rerio). PubMed: Bioaccumulation and biotransformation of chiral triazole fungicides in rainbow trout (Oncorhynchus mykiss). PubMed: MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides. PubMed: Fungicides affect the production of extracellular mucilaginous material (ECMM) and the peripheral growth unit (PGU) in two wood-rotting basidiomycetes. PubMed: Influence of pH on the stereoselective degradation of the fungicides epoxiconazole and cyproconazole in soils. PubMed: Selection for increased cyproconazole tolerance in Mycosphaerella graminicola through local adaptation and in response to host resistance. PubMed: MgSlt2, a cellular integrity MAP kinase gene of the fungal wheat pathogen Mycosphaerella graminicola, is dispensable for penetration but essential for invasive growth. PubMed: In vitro selection of an effective fungicide against Armillaria mellea and control of white root rot of grapevine in the field. PubMed: Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry. PubMed: Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. PubMed: Capillary electrophoresis for analyzing pesticides in fruits and vegetables using solid-phase extraction and stir-bar sorptive extraction. PubMed: Application of solid-phase extraction to quantitatively determine cyproconazole and tebuconazole in treated wood using liquid chromatography with UV detection. PubMed: Liquid chromatography-electrospray quadrupole ion-trap mass spectrometry of nine pesticides in fruits. PubMed: Chiral separation of some triazole pesticides by supercritical fluid chromatography. PubMed: Evaluation of a method based on liquid chromatography/electrospray tandem mass spectrometry for analyzing eight triazolic and pyrimidine fungicides in extracts of processed fruits and vegetables. PubMed: Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola. PubMed: Triazole fungicide degradation in peaches in the field and in model systems. PubMed: ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola. PubMed: Molecular cloning and characterisation of three new ATP-binding cassette transporter genes from the wheat pathogen Mycosphaerella graminicola. PubMed: High-performance chiral separation of fourteen triazole fungicides by sulfated beta-cyclodextrin-mediated capillary electrophoresis. PubMed: Characterization of the ABC transporter genes MgAtr1 and MgAtr2 from the wheat pathogen Mycosphaerella graminicola. PubMed: Pesticide residues in grapes, wine, and their processing products. PubMed: Multiresidue determination of 19 fungicides in processed fruits and vegetables by capillary gas chromatography after gel permeation chromatography. PubMed: Developmental toxicity of cyproconazole, an inhibitor of fungal ergosterol biosynthesis, in the rat.