cyproconazole
2-(4-chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazolyl)butan-2-ol
Identification
| Name | cyproconazole |
| CAS Number | 94361-06-5 |
| FDA UNII | 622B9C3E6T |
| Molecular Formula | C15 H18 Cl N3 O |
| Molecular Weight | 291.78066000 |
| MDL Number | MFCD01678672 |
| Nikkaji Number | J633.729E |
| Beilstein | 8396421 |
| XlogP3 | 2.90 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 107.50 °C. @ 760.00 mm Hg |
| Boiling Point | 479.13 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 2.590000 mmHg @ 25.00 °C. (est) |
| Flash Point | 470.00 °F. TCC ( 243.60 °C. ) (est) |
| logP (o/w) | 2.900 |
| Soluble in | water, 140 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-mouse LD50 352 mg/kg |
| Dermal Toxicity | skin-rat LD50 > 2000 mg/kg |
| Inhalation Toxicity | inhalation-rat LC50 > 5650 mg/m3/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for cyproconazole usage levels up to | not for fragrance use. |
| Recommendation for cyproconazole flavor usage levels up to | not for flavor use. |
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Potential Uses
Natural Occurrence
Synonyms
atemi C
2-(4-
chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazol-1-yl)butan-2-ol
2-(4-
chlorophenyl)-3-cyclopropyl-1-(1,2,4-triazolyl)butan-2-ol
2-(4-
chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol
(2RS,3RS)-2-(4-
chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
2-(4-
chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
1H-1,2,4-
triazole-1-ethanol, a-(4-chlorophenyl)-a-(1-cyclopropylethyl)-
PubMed:
Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery.
PubMed:
Pathogenesis-Related Protein Expression in the Apoplast of Wheat Leaves Protected Against Leaf Rust Following Application of Plant Extracts.
PubMed:
Concordance of transcriptional and apical benchmark dose levels for conazole-induced liver effects in mice.
PubMed:
Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.
PubMed:
Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells.
PubMed:
Dynamics and mitigation of six pesticides in a "Wet" forest buffer zone.
PubMed:
Association between virulence and triazole tolerance in the phytopathogenic fungus Mycosphaerella graminicola.
PubMed:
Effects of mixtures of azole fungicides in postimplantation rat whole-embryo cultures.
PubMed:
Direct enantioseparation of nitrogen-heterocyclic pesticides on amylose-tris-(5-chloro-2-methylphenylcarbamate) by reversed-phase high-performance liquid chromatography.
PubMed:
Triazole induced concentration-related gene signatures in rat whole embryo culture.
PubMed:
Triazole-induced gene expression changes in the zebrafish embryo.
PubMed:
HPLC-MS/MS enantioseparation of triazole fungicides using polysaccharide-based stationary phases.
PubMed:
Toxicity assessment of 45 pesticides to the epigeic earthworm Eisenia fetida.
PubMed:
Residues behavior of some fungicides applied on two greenhouse tomato varieties different in shape and weight.
PubMed:
The hepatocarcinogenic conazoles: cyproconazole, epoxiconazole, and propiconazole induce a common set of toxicological and transcriptional responses.
PubMed:
Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn).
PubMed:
Environmental fate of fungicides in surface waters of a horticultural-production catchment in southeastern Australia.
PubMed:
Is the amphibian X. laevis WEC a good alternative method to rodent WEC teratogenicity assay? The example of the three triazole derivative fungicides Triadimefon, Tebuconazole, Cyproconazole.
PubMed:
Determination of azoles in sewage sludge from Spanish wastewater treatment plants by liquid chromatography-tandem mass spectrometry.
PubMed:
Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles.
PubMed:
Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies.
PubMed:
Fungicide dissipation and impact on metolachlor aerobic soil degradation and soil microbial dynamics.
PubMed:
Occurrence and removal of fungicides in municipal sewage treatment plant.
PubMed:
Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD-modified MEKC.
PubMed:
In vitro toxicity of selected fungicides from the groups of benzimidazoles and demethylation inhibitors to Cladobotryum dendroides and Agaricus bisporus.
PubMed:
The effect of fungicides on seed yield and disease control in Italian ryegrass.
PubMed:
Development of monoclonal immunoassays for the determination of triazole fungicides in fruit juices.
PubMed:
The toxicity study of a systemic fungicide: artea 330 EC on the physiology and the respiratory metabolism of the tadpole (Rana saharica).
PubMed:
Photocatalytic degradation of pesticides in pure water and a commercial agricultural solution on TiO2 coated media.
PubMed:
[Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates].
PubMed:
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.
PubMed:
Control of Mycosphaerella graminicola on wheat seedlings by medical drugs known to modulate the activity of ATP-binding cassette transporters.
PubMed:
Capabilities of different liquid chromatography tandem mass spectrometry systems in determining pesticide residues in food. Application to estimate their daily intake.
PubMed:
Sexual reproduction facilitates the adaptation of parasites to antagonistic host environments: Evidence from empirical study in the wheat-Mycosphaerella graminicola system.
PubMed:
Use of SPE-GC/EIMS for residue analysis in wine elaborated from musts spiked with formulations of chlorpyriphos-methyl, methiocarb, dicofol, and cyproconazol.
PubMed:
Effects of two systemic fungicides: Artea (Propiconazole+cyproconazole) and Punch (Flusilazole) on the physiology and the respiratory metabolism of durum wheat (Triticum durum L.).
PubMed:
Testing estrogenicity of known and novel (xeno-)estrogens in the MolDarT using developing zebrafish (Danio rerio).
PubMed:
Bioaccumulation and biotransformation of chiral triazole fungicides in rainbow trout (Oncorhynchus mykiss).
PubMed:
MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides.
PubMed:
Fungicides affect the production of extracellular mucilaginous material (ECMM) and the peripheral growth unit (PGU) in two wood-rotting basidiomycetes.
PubMed:
Influence of pH on the stereoselective degradation of the fungicides epoxiconazole and cyproconazole in soils.
PubMed:
Selection for increased cyproconazole tolerance in Mycosphaerella graminicola through local adaptation and in response to host resistance.
PubMed:
MgSlt2, a cellular integrity MAP kinase gene of the fungal wheat pathogen Mycosphaerella graminicola, is dispensable for penetration but essential for invasive growth.
PubMed:
In vitro selection of an effective fungicide against Armillaria mellea and control of white root rot of grapevine in the field.
PubMed:
Determination of 22 triazole compounds including parent fungicides and metabolites in apples, peaches, flour, and water by liquid chromatography/tandem mass spectrometry.
PubMed:
Determination of azolic fungicides in wine by solid-phase extraction and high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
PubMed:
Capillary electrophoresis for analyzing pesticides in fruits and vegetables using solid-phase extraction and stir-bar sorptive extraction.
PubMed:
Application of solid-phase extraction to quantitatively determine cyproconazole and tebuconazole in treated wood using liquid chromatography with UV detection.
PubMed:
Liquid chromatography-electrospray quadrupole ion-trap mass spectrometry of nine pesticides in fruits.
PubMed:
Chiral separation of some triazole pesticides by supercritical fluid chromatography.
PubMed:
Evaluation of a method based on liquid chromatography/electrospray tandem mass spectrometry for analyzing eight triazolic and pyrimidine fungicides in extracts of processed fruits and vegetables.
PubMed:
Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola.
PubMed:
Triazole fungicide degradation in peaches in the field and in model systems.
PubMed:
ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola.
PubMed:
Molecular cloning and characterisation of three new ATP-binding cassette transporter genes from the wheat pathogen Mycosphaerella graminicola.
PubMed:
High-performance chiral separation of fourteen triazole fungicides by sulfated beta-cyclodextrin-mediated capillary electrophoresis.
PubMed:
Characterization of the ABC transporter genes MgAtr1 and MgAtr2 from the wheat pathogen Mycosphaerella graminicola.
PubMed:
Pesticide residues in grapes, wine, and their processing products.
PubMed:
Multiresidue determination of 19 fungicides in processed fruits and vegetables by capillary gas chromatography after gel permeation chromatography.
PubMed:
Developmental toxicity of cyproconazole, an inhibitor of fungal ergosterol biosynthesis, in the rat.