bezafibrate

2-{4-[2-(4-chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid

CAS: 41859-67-0 C19 H20 Cl N O4 MW: 361.82420000

Identification

Namebezafibrate
CAS Number41859-67-0
EINECS255-567-9
FDA UNIIY9449Q51XH
Molecular FormulaC19 H20 Cl N O4
Molecular Weight361.82420000
MDL NumberMFCD00078970
Nikkaji NumberJ16.626J
Beilstein4267656
XlogP33.80 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 186.00 °C. @ 760.00 mm Hg
Boiling Point 572.10 °C. @ 760.00 mm Hg (est)
Flash Point 572.00 °F. TCC ( 299.80 °C. ) (est)
logP (o/w) 2.504 (est)
Soluble in water, 1.224 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-man TDLo 514 mg/kg/60D-
Dermal Toxicitysubcutaneous-mouse LD50 1635 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nLUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for bezafibrate usage levels up tonot for fragrance use.
Recommendation for bezafibrate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

azufibrat befibrat bezafibratum bezalande bezapuren 2-(p-(2-(p- chlorobenzamido)ethyl)phenoxy)-2-methylpropionic acid 2-[4-[2-(4- chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid 2-[p-[2-(p- chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid 2-[p-[2-p- chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid 2-{4-[2-(4- chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid 2-[4-[2-[(4- chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid 2-[4-[2-[(4- chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid 2-(4-{2-[(4- chlorophenyl)carbonylamino]ethyl}phenoxy)-2-methylpropanoic acid difaterol durabezur propanoic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl- propanoic acid, 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl- propionic acid, 2-(4-(2-((4-chlorobenzoyl)amino)ethyl)phenoxy)-2-methyl- reducterol sklerofibrat PubMed: Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks. PubMed: Quantitative evaluation of initial symptoms as predictors to detect adverse drug reactions using Bayes' theory: expansion and evaluation of drug-adverse drug reaction-initial symptom combinations using adverse event reporting system database. PubMed: Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater. PubMed: Long-chain free fatty acid profiling analysis by liquid chromatography-mass spectrometry in mouse treated with peroxisome proliferator-activated receptor α agonist. PubMed: Melanocortin 4 receptor becomes an ACTH receptor by coexpression of melanocortin receptor accessory protein 2. PubMed: Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice. PubMed: Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ). PubMed: Peroxisome proliferator-activated receptor α (PPARα) activation advances locomotor activity and feeding daily rhythms in mice. PubMed: Bezafibrate, a lipid-lowering pharmaceutical, as a potential endocrine disruptor in male zebrafish (Danio rerio). PubMed: Activation of peroxisome proliferator-activated receptor-α (PPARα) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes. PubMed: Nutritional and metabolic status of HIV-positive patients with lipodystrophy during one year of follow-up. PubMed: Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome. PubMed: Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. PubMed: Bezafibrate induces myotoxicity in human rhabdomyosarcoma cells via peroxisome proliferator-activated receptor alpha signaling. PubMed: Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms. PubMed: Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice. PubMed: Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists. PubMed: Differential effects of pyrazinamide and clofibrate on gene expression of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme of the tryptophan-NAD pathway. PubMed: Ethanolamine modulates DNA synthesis through epidermal growth factor receptor in rat primary hepatocytes. PubMed: Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. PubMed: Bezafibrate on lipids and glucose metabolism in obese diabetic Otsuka Long-Evans Tokushima fatty rats. PubMed: Hypertriglyceridemia: associated risks and effect of drug treatment. PubMed: Bezafibrate-induced anaphylactic shock: unusual clinical presentation. PubMed: Bezafibrate induces acyl-CoA oxidase mRNA levels and fatty acid peroxisomal beta-oxidation in rat white adipose tissue. PubMed: Beneficial changes in serum apo A-1 and its ratio to apo B and HDL in stable hyperlipidaemic subjects after Ramadan fasting in Kuwait. PubMed: Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth. PubMed: The patient at risk: who should we be treating? PubMed: The patient at risk: who should we be treating? PubMed: Treatment of primary hypercholesterolemia: fluvastatin versus bezafibrate. PubMed: Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates. PubMed: The role of NADPH in the regulation of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rat adipose tissue. PubMed: Comparative studies on the influence of different fibrates on serum lipoproteins in endogenous hyperlipoproteinaemia. PubMed: Modification of low density lipoproteins from hypertriglyceridemic patients by macrophages in vitro and the effect of bezafibrate treatment.