leucovorin calcium
L-glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
Identification
| Name | leucovorin calcium |
| CAS Number | 1492-18-8 |
| EINECS | 216-082-8 |
| FDA UNII | RPR1R4C0P4 |
| Molecular Formula | C20 H21 Ca N7 O7 |
| Molecular Weight | 511.50877000 |
| MDL Number | MFCD00006704 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -3.187 (est) |
| Soluble in | water, 3324 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 1036 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for leucovorin calcium usage levels up to | not for fragrance use. |
| Recommendation for leucovorin calcium flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-hydroxy-5,6,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate
calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate
(6S)-
calcium folinate
calcium leucovorin
calcium, [L-glutamato(2-)-kappaO1,kappaO5, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-]-
calcium;2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
calciumlevofolinate
(+)-L-
folinic acid calcium salt
5-
formlyl-5,6,7,8-tetrahydrofolic acid, calcium salt
5-
formyl-5,6,7,8-tetrahydrofolic acid calcium salt
L-
glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
leucovorin calcium salt
wellcovorin
PubMed:
[A case of pathological complete response with neoadjuvant mFOLFOX6 chemotherapy for advanced lower rectal cancer].
PubMed:
Analysis of saliva samples from oncological patients treated with 5-fluorouracil and leucovorin calcium by scanning electron microscopy with energy dispersive system.
PubMed:
Early ovarian pregnancy diagnosed by ultrasound and successfully treated with multidose methotrexate. A case report.
PubMed:
A phase II randomized study of combined infusional leucovorin sodium and 5- FU versus the leucovorin calcium followed by 5-FU both in combination with irinotecan or oxaliplatin in patients with metastatic colorectal cancer.
PubMed:
A clinical study on safety and efficacy of Aidi injection combined with chemotherapy.
PubMed:
Cerebral folate receptor autoantibodies in autism spectrum disorder.
PubMed:
Use of uridine triacetate for the management of fluorouracil overdose.
PubMed:
Combination adjuvant chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin after liver transplantation for hepatocellular carcinoma: a preliminary open-label study.
PubMed:
Clinical observation of Endostar® combined with chemotherapy in advanced colorectal cancer patients.
PubMed:
Hyperbranched poly(amine-ester) based hydrogels for controlled multi-drug release in combination chemotherapy.
PubMed:
Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using solid phase extraction and chiral liquid chromatography-tandem mass spectrometry.
PubMed:
Oral signs of intravenous chemotherapy with 5-Fluorouracil and Leucovorin calcium in colon cancer treatment.
PubMed:
[Efficacy of oxaliplatin plus 5-fluorouracil/leucovorin calcium combined with concurrent radiotherapy for local advanced gastric cancer].
PubMed:
Variation in the cost of medications for the treatment of colorectal cancer.
PubMed:
Oxaliplatin-induced hypersensitivity reaction displaying marked elevation of immunoglobulin E.
PubMed:
Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer.
PubMed:
Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: an underestimated phenomenon.
PubMed:
Leucovorin (calcium folinate) in "antifreeze" poisoning.
PubMed:
Preoperative FLAC/granulocyte-colony-stimulating factor chemotherapy for stage II breast cancer: a prospective randomized trial.
PubMed:
Cobalamin C disease presenting as hemolytic-uremic syndrome in the neonatal period.
PubMed:
Phenytoin and fluorouracil interaction.
PubMed:
UFT plus oral leucovorin calcium (Orzel) and radiation in combined modality therapy: a comprehensive review.
PubMed:
High-dose methotrexate-doxycycline interaction.
PubMed:
Phase II trial of intermediate dose methotrexate in combination with vinblastine, doxorubicin, and cisplatin in patients with unresectable or metastatic transitional cell carcinoma.
PubMed:
Common vitamin B complex agents and folic acid: Part IV. Leucovorin calcium (citrovorum factor, folinic acid [wellcovorin]).
PubMed:
5-Fluorouracil and d,l-leucovorin calcium are active to treat unresectable hepatocellular carcinoma patients: preliminary results of a phase II study.
PubMed:
[Intra-arterial 5-FU/intra-venous MTX therapy for metastatic liver lesions].
PubMed:
Modulation of 5-fluorouracil with high-dose leucovorin calcium: activity in ovarian cancer and correlation with CA-125 levels.
PubMed:
California: new drugs added to AIDS drug assistance program.
PubMed:
Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia.
PubMed:
Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium.
PubMed:
Clinical pharmacokinetics and pharmacology of trimetrexate.
PubMed:
Cisplatin, fluorouracil, and leucovorin. Increased toxicity without improved response in squamous cell head and neck cancer.
PubMed:
Substitution of l-leucovorin for d,l-leucovorin in the rescue from high-dose methotrexate treatment in patients with osteosarcoma.
PubMed:
A thin-layer chromatographic method to determine process impurities in leucovorin calcium.
PubMed:
Phase II trial of 5-fluorouracil, high-dose leucovorin calcium, and dipyridamole in advanced prostate cancer.
PubMed:
Drug treatment of colorectal cancer. Current status.
PubMed:
Phase I clinical trial with floxuridine and high-dose continuous infusion of leucovorin calcium.
PubMed:
Oral zidovudine, continuous-infusion fluorouracil, and oral leucovorin calcium: a phase I study.
PubMed:
Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration.
PubMed:
[The results of simultaneous radio-chemotherapy in advanced head and neck tumors].
PubMed:
Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.
PubMed:
Pulmonary carcinoid presenting as multiple subcutaneous nodules.
PubMed:
Toxicity of vincristine overdose in a patient with invasive mole.
PubMed:
Phase I trial of semustine plus weekly fluorouracil and high-dose leucovorin calcium in patients with advanced colorectal cancer.
PubMed:
[Management of the administration of leucovorin calcium in high-dose methotrexate therapy].
PubMed:
Leucovorin calcium enhancement of mucositis after continuous infusion fluorouracil and short infusion cisplatin.
PubMed:
Stability of floxuridine and leucovorin calcium admixtures for intraperitoneal administration.
PubMed:
Cisplatin, fluorouracil with leucovorin calcium enhancement, and synchronous accelerated radiotherapy in the management of locally advanced head and neck cancer: a phase II study.
PubMed:
Refractory metastatic breast cancer: salvage therapy with fluorouracil and high-dose continuous infusion leucovorin calcium.
PubMed:
New vistas for leucovorin in cancer chemotherapy.
PubMed:
Bioequivalence of two leucovorin calcium tablet formulations.
PubMed:
Diminishing bioavailability of oral leucovorin calcium.
PubMed:
Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma.
PubMed:
Haziness in leucovorin calcium for injection.
PubMed:
Pharmacokinetics of leucovorin calcium after intravenous, intramuscular, and oral administration.
PubMed:
Treatment of advanced-stage colorectal adenocarcinoma with fluorouracil and high-dose leucovorin calcium: a pilot study.
PubMed:
Acute bullous dermatosis and onycholysis due to high-dose methotrexate and leucovorin calcium.
PubMed:
Absorption kinetics of orally administered leucovorin calcium.
PubMed:
Primary chemotherapy for localized non-Hodgkin's lymphomas with diffuse histologic characteristics. Preliminary report of a prospective study.
PubMed:
Surgical complications in patients with head and neck cancer receiving chemotherapy.
PubMed:
Maintenance chemotherapy for high-risk patients. A preliminary report.
PubMed:
Purity profiles of pteroylglutamate reference substances by high-performance liquid chromatography.
PubMed:
Preparing cancer patients to administer medication.
PubMed:
Stability and compatibility of antitumor agents in glass and plastic containers.
PubMed:
Clinical and laboratory reevalution of dichloromethotrexate.
PubMed:
High-dose methotrexate in combination chemotherapy for small cell lung cancer.
PubMed:
Adjuvant methotrexate and leucovorin in head and neck squamous cancer. Two-year follow-up of a pilot project.
PubMed:
Methotrexate-induced renal failure and ineffectiveness of peritoneal dialysis.
PubMed:
Leucovorin calcium administration and preparation.
PubMed:
Mycosis fungoides with pulmonary involvement. A complete remission.
PubMed:
Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement.
PubMed:
T-cell rosette test in squamous cell carcinoma of the head and neck.
PubMed:
Studies in bullous diseases. Treatment of pemphigus vulgaris with immunosuppressives (steroids and methotrexate) and leucovorin calcium.
PubMed:
Acute toxoplasmosis. Effective treatment with pyrimethamine, sulfadiazine, leucovorin calcium, and yeast.
PubMed:
LEUCOVORIN calcium.