1-deoxynojirimycin

D-5- amino-1,5-dideoxyglucopyranose 1,5- deoxy-1,5-imino-D-mannitol 1- deoxy-nojirimycin 1- deoxymannojirimycin 1,5- dideoxy-1,5-imino-D-glucitol duvoglustat (2R,3R,4R,5S)-2- hydroxymethyl-3,4,5-trihydroxypiperidine (2R,3R,4R,5S)-2- hydroxymethyl-piperidine-3,4,5-triol [2R-(2a,3b,4a,5b)]-2-( hydroxymethyl)-3,4,5-piperidinetriol (2R,3R,4R,5S)-2-( hydroxymethyl)piperidine-3,4,5-triol moranoline 3,4,5- piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)- PubMed: Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity. PubMed: Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice. PubMed: Metabolic Effect of 1-Deoxynojirimycin from Mulberry Leaves on db/db Diabetic Mice Using Liquid Chromatography-Mass Spectrometry Based Metabolomics. PubMed: Fate of d-Fagomine after Oral Administration to Rats. PubMed: Decreased formation of branched-chain short fatty acids in Bacillus amyloliquefaciens by metabolic engineering. PubMed: Use of Bacillus amyloliquefaciens HZ-12 for High-Level Production of the Blood Glucose Lowering Compound, 1-Deoxynojirimycin (DNJ), and Nutraceutical Enriched Soybeans via Fermentation. PubMed: Supplementation of a Fermented Soybean Extract Reduces Body Mass and Prevents Obesity in High Fat Diet-Induced C57BL/6J Obese Mice. PubMed: A 28-Day Repeated Dose Toxicological Study of an Aqueous Extract of Morus Alba L. PubMed: Effects of Applied Nitrogen Amounts on the Functional Components of Mulberry (Morus alba L.) Leaves. PubMed: Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. PubMed: Prevention Effects and Possible Molecular Mechanism of Mulberry Leaf Extract and its Formulation on Rats with Insulin-Insensitivity. PubMed: Pressurized liquid extraction of Aglaonema sp. iminosugars: Chemical composition, bioactivity, cell viability and thermal stability. PubMed: Identification and Determination of the Polyhydroxylated Alkaloids Compounds with α-Glucosidase Inhibitor Activity in Mulberry Leaves of Different Origins. PubMed: Effect of solar radiation on the functional components of mulberry (Morus alba L.) leaves. PubMed: Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice. PubMed: Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte. PubMed: Mulberry 1-Deoxynojirimycin Inhibits Adipogenesis by Repression of the ERK/PPARγ Signaling Pathway in Porcine Intramuscular Adipocytes. PubMed: Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders. PubMed: Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue. PubMed: 1-deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat-fed mice. PubMed: Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo-controlled trial. PubMed: A Comparison of Food-grade Folium mori ( Sāng Yè) Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats. PubMed: Comparative evaluation of polysaccharides isolated from Astragalus, oyster mushroom, and yacon as inhibitors of α-glucosidase. PubMed: 1-Deoxynojirimycin attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells. PubMed: Evaluation of general toxicity and genotoxicity of the silkworm extract powder. PubMed: Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients. PubMed: Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of FAK. PubMed: Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. PubMed: Comparison of inhibitory activities and mechanisms of five mulberry plant bioactive components against α-glucosidase. PubMed: Studies targeting α-glucosidase inhibition, antiangiogenic effects, and lipid modification regulation: background, evaluation, and challenges in the development of food ingredients for therapeutic purposes. PubMed: 1-Deoxynojirimycin isolated from a Bacillus subtilis stimulates adiponectin and GLUT4 expressions in 3T3-L1 adipocytes. PubMed: Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice. PubMed: Kinetic and thermodynamic analysis of the inhibitory effects of maltose, glucose, and related carbohydrates on wheat β-amylase. PubMed: A novel gelatin crosslinking method retards release of mulberry 1-deoxynojirimycin providing a prolonged hypoglycaemic effect. PubMed: Isolation of the putative biosynthetic gene cluster of 1-deoxynojirimycin by Bacillus amyloliquefaciens 140N, its production and application to the fermentation of soybean paste. PubMed: Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species. PubMed: Dysphagia as a risk factor for mortality in Niemann-Pick disease type C: systematic literature review and evidence from studies with miglustat. PubMed: Anti-diabetic effect of a traditional Chinese medicine formula. PubMed: Traditional medicinal herbs and food plants have the potential to inhibit key carbohydrate hydrolyzing enzymes in vitro and reduce postprandial blood glucose peaks in vivo. PubMed: Effect of environmental conditions on the α-glucosidase inhibitory activity of mulberry leaves. PubMed: [Report of attendance at the Parseghian Scientific Conference for Niemann-Pick Type C (NP-C) Research, South Bend, Indiana: in search of new therapeutic possibilities for a very rare illness]. PubMed: Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin. PubMed: Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation. PubMed: Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism. PubMed: Identification of the genes involved in 1-deoxynojirimycin synthesis in Bacillus subtilis MORI 3K-85. PubMed: Comparison of 1-deoxynojirimycin and aqueous mulberry leaf extract with emphasis on postprandial hypoglycemic effects: in vivo and in vitro studies. PubMed: 1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation. PubMed: Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men. PubMed: Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men. PubMed: Simple, selective, and rapid quantification of 1-deoxynojirimycin in mulberry leaf products by high-performance anion-exchange chromatography with pulsed amperometric detection. PubMed: Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography-tandem mass spectrometry. PubMed: Comparison of absorption of 1-deoxynojirimycin from mulberry water extract in rats. PubMed: Purification and identification of 1-deoxynojirimycin (DNJ) in okara fermented by Bacillus subtilis B2 from Chinese traditional food (Meitaoza). PubMed: Optimization of 1-deoxynojirimycin extraction from mulberry leaves by using response surface methodology. PubMed: Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver. PubMed: Phytochemical profiles of different mulberry (Morus sp.) species from China. PubMed: Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: application to pharmacokinetic studies. PubMed: Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity. PubMed: Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models. PubMed: N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice. PubMed: [In-vitro study of the drug interactions between Miglitol, an alpha-glucosidase inhibitor, and adsorbents]. PubMed: Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. PubMed: Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. PubMed: Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. PubMed: Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats. PubMed: The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study. PubMed: Binding residues and catalytic domain of soluble Saccharomyces cerevisiae processing alpha-glucosidase I. PubMed: Inhibitory effects of mulberry leaf extract on postprandial hyperglycemia in normal rats. PubMed: Determination of 1-deoxynojirimycin in mulberry leaves using hydrophilic interaction chromatography with evaporative light scattering detection. PubMed: An improved purification procedure for soluble processing alpha-glucosidase I from Saccharomyces cerevisiae overexpressing CWH41. PubMed: Detailed kinetic analysis of a family 52 glycoside hydrolase: a beta-xylosidase from Geobacillus stearothermophilus. PubMed: Purification and characterization of vanilla bean (Vanilla planifolia Andrews) beta-D-glucosidase. PubMed: A novel method for the assay of alpha-glucosidase inhibitory activity using a multi-channel oxygen sensor. PubMed: The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics. PubMed: Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study. PubMed: Alpha-retaining glucosyl transfer catalysed by trehalose phosphorylase from Schizophyllum commune: mechanistic evidence obtained from steady-state kinetic studies with substrate analogues and inhibitors. PubMed: Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). PubMed: Glucosidase inhibitor from Umbilicaria esculenta. PubMed: Glucose tolerance and insulin resistance in the JCR:LA-corpulent rat: effect of miglitol (Bay m1099). PubMed: Miglitol (BAY m 1099) treatment of diabetic hypothalamic-dietary obese rats improves islet response to glucose. PubMed: Advantages of alpha-glucosidase inhibition as monotherapy in elderly type 2 diabetic patients. PubMed: Effect of miglitol administration to non-insulin-dependent diabetic rats. PubMed: Differential scanning calorimetric studies on the domain structure of Aspergillus glucoamylase. PubMed: Effects of Bay m 1099, an α-Glucosidase Inhibitor, on Starch Metabolism in Germinating Wheat Seeds. PubMed: The effects of the intestinal glucosidase inhibitory BAY M 1099 (miglitol) on glycemic status of obese-diabetic rats. PubMed: alpha-Glucosidase inhibition by miglitol in NIDDM patients. PubMed: The effects of low-dose Bay-m-1099 (Miglitol) on serum lipids and liver enzyme activity of obese and obese-diabetic corpulent rats. PubMed: Inhibition of intestinal alpha-glucosidase and postprandial hyperglycemia by N-substituted moranoline derivatives. PubMed: The effect of two new alpha-glucosidase inhibitors on metabolic responses to a mixed meal in normal volunteers. PubMed: Chronic effects of an alpha-glucosidase inhibitor (Bay o 1248) on intestinal disaccharidase activity in normal and diabetic mice. PubMed: Influence of an absorbable alpha-glucosidase inhibitor (Bay o 1248) on the endocrine and exocrine pancreas of the rat. PubMed: Effect of the alpha-glucosidase inhibitor Bay-O-1248 on the metabolic response of nondiabetic and diabetic rats to a high-carbohydrate diet.