protodioscin
furost-5-ene-3,22,26-triol 3-chacotrioside-26-glucopyranoside
Identification
| Name | protodioscin |
| CAS Number | 55056-80-9 |
| FDA UNII | D0LC3PH24P |
| Molecular Formula | C51 H84 O22 |
| Molecular Weight | 1049.21288000 |
| Nikkaji Number | J445.547I |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | 0.232 (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for protodioscin usage levels up to | not for fragrance use. |
| Recommendation for protodioscin flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Jiangyin Healthway International Trade Co., Ltd
Independent Ingredients Supplier
We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
Potential Uses
Natural Occurrence
Synonyms
furost-5-ene-3,22,26-triol 3-chacotrioside-26-glucopyranoside
furostanol I
PubMed:
A Comparative Tissue-specific Metabolite Analysis and Determination of Protodioscin Content in Asparagus Species used in Traditional Chinese Medicine and Ayurveda by use of Laser Microdissection, UHPLC-QTOF/MS and LC-MS/MS.
J-Stage:
Effects of Various Asparagus Production Methods on Rutin and Protodioscin Contents in Spears and Cladophylls
PubMed:
Poisoning by Brachiaria brizantha in flocks of naïve and experienced sheep.
J-Stage:
A New Spirostanol Glycoside from Fruits of Solanum indicum L.
PubMed:
Performance of sheep grazing in pastures of Brachiaria decumbens, Brachiaria brizantha, Panicum maximum, and Andropogon gayanus with different protodioscin concentrations.
J-Stage:
A New Steroidal Saponin from Dioscorea cayenensis
PubMed:
Saponin profile of green asparagus genotypes.
J-Stage:
Effects of Two Saponins Extracted from the Polygonatum Zanlanscianense Pamp on the Human Leukemia (HL-60) Cells
PubMed:
Hepatic photosensitization in buffaloes intoxicated by Brachiaria decumbens in Minas Gerais state, Brazil.
PubMed:
Optimization of a method for the profiling and quantification of saponins in different green asparagus genotypes.
PubMed:
Two spirostan steroid glycoside fatty esters from Dioscorea cayenensis.
PubMed:
Potential nephrotoxic effects produced by steroidal saponins from hydro alcoholic extract of Tribulus terrestris in STZ-induced diabetic rats.
PubMed:
Protodioscin-glycosidase-1 hydrolyzing 26-O-β-D-glucoside and 3-O-(1 â 4)-α-L-rhamnoside of steroidal saponins from Aspergillus oryzae.
PubMed:
Highly efficient sample preparation and quantification of constituents from traditional Chinese herbal medicines using matrix solid-phase dispersion extraction and UPLC-MS/MS.
PubMed:
Development of an analytical method for yam saponins using HPLC with pulsed amperometric detection at different column temperatures.
PubMed:
Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.
PubMed:
Fenugreek with reduced bitterness prevents diet-induced metabolic disorders in rats.
PubMed:
Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.
PubMed:
Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.
PubMed:
Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears.
PubMed:
Differential activity of multiple saponins against omnivorous insects with varying feeding preferences.
PubMed:
[Determination by high performance chromatography, steroid saponins in a biologically active food supplements containing the extract of Tribulus terrestris].
PubMed:
Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC-MS/MS.
PubMed:
[Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].
PubMed:
Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.
PubMed:
The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.
PubMed:
Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles.
PubMed:
Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.
PubMed:
Pharmacokinetics of methyl protodioscin in rats.
PubMed:
[Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].
PubMed:
A new spirostanol glycoside from fruits of Solanum indicum L.
PubMed:
Steroidal saponins from Smilax excelsa rhizomes.
PubMed:
[Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].
PubMed:
New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.
PubMed:
Pregnane glycosides and steroid saponins from Smilax bockii Warb. and their NGF-potentiating activity.
PubMed:
The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat.
PubMed:
Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.
PubMed:
Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.
PubMed:
Distribution of steroidal saponins in Tribulus terrestris from different geographical regions.
PubMed:
Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.
PubMed:
[Study on steroidal saponins of Dioscorea septemloba thunb].
PubMed:
Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.
PubMed:
Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.
PubMed:
Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.
PubMed:
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
PubMed:
[Study on chemical constituents in total saponin from Trigonella foenum-graecum].
PubMed:
Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.
PubMed:
A new steroidal saponin from Dioscorea cayenensis.
PubMed:
Microbial metabolism of pseudoprotodioscin.
PubMed:
Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.
PubMed:
Steroidal saponins from Dioscorea panthaica and their cytotoxic activity.
PubMed:
In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.
PubMed:
Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).
PubMed:
Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.
PubMed:
Furostanol saponins from Tribulus terrestris.
PubMed:
The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.
PubMed:
Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.
PubMed:
Total synthesis of methyl protodioscin: a potent agent with antitumor activity.
PubMed:
Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.
PubMed:
Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.
PubMed:
Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.
PubMed:
Two new sulfated furostanol saponins from Tribulus terrestris.
PubMed:
Determination of steroidal saponins in Tribulus terrestris by reversed-phase high-performance liquid chromatography and evaporative light scattering detection.
PubMed:
Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
PubMed:
Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions.
PubMed:
Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum.
PubMed:
Steroidal saponins from Asparagus officinalis and their cytotoxic activity.
PubMed:
Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.
PubMed:
Steroidal saponins from the rhizomes of Smilax menispermoidea.
PubMed:
Experimental antitumor agents from Solanum indicum L.
PubMed:
[beta-Glucosidases from fungus Geotrichum candidum].