madecassic acid
urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)-
Identification
| Name | madecassic acid |
| CAS Number | 18449-41-7 |
| FDA UNII | M7O1N24J82 |
| Molecular Formula | C30 H48 O6 |
| Molecular Weight | 504.70776000 |
| MDL Number | MFCD00895441 |
| Nikkaji Number | J39.267G |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 641.65 °C. @ 760.00 mm Hg (est) |
| Flash Point | 673.00 °F. TCC ( 355.90 °C. ) (est) |
| logP (o/w) | 4.321 (est) |
| Soluble in | water, 0.9738 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for madecassic acid usage levels up to | not for fragrance use. |
| Recommendation for madecassic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
brahmic acid
(1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11-
trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)-
PubMed:
Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban.
PubMed:
[Studies on fingerprints of Centella asiatica by HPLC].
PubMed:
Two new triterpene glycosides from Centella asiatica.
PubMed:
Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation.
PubMed:
Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma.
PubMed:
Centella asiatica in dermatology: an overview.
PubMed:
Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban.
PubMed:
[Simultaneous determination of madecassoside,asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC].
PubMed:
Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs.
PubMed:
Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.
PubMed:
Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts.
PubMed:
Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats.
PubMed:
Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice.
PubMed:
[Studies on fingerprints of Centella asiatica by HPLC].
PubMed:
Triterpene composition and bioactivities of Centella asiatica.
PubMed:
Two new triterpene glycosides from Centella asiatica.
PubMed:
Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban.
PubMed:
Conversion of alpha-amyrin into centellosides by plant cell cultures of Centella asiatica.
PubMed:
Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells.
PubMed:
An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE).
PubMed:
Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica.
PubMed:
Association (micellization) and partitioning of aglycon triterpenoids.
PubMed:
Incorporation of triterpenic derivatives within an o/w/o multiple emulsion: structure and release studies.
PubMed:
Molecular dynamics simulation and thermodynamic modeling of the self-assembly of the triterpenoids asiatic acid and madecassic acid in aqueous solution.
PubMed:
[Separation and determination of madecassic acid in triterpenic genins of Centella asiatica by high performance liquid chromatography using beta-cyclodextrin as mobile phase additive].
PubMed:
Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry.
PubMed:
Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica.
PubMed:
Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids.
PubMed:
An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products.
PubMed:
Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka.
PubMed:
New innovations in scar management.
PubMed:
Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice.
PubMed:
Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds.
PubMed:
Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban.
PubMed:
Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis.
PubMed:
Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer.
PubMed:
Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica.
PubMed:
Contact dermatitis due to madecassol.
PubMed:
The metabolism of asiatic acid,-madecassic acid and asiaticoside in the rat.