madecassic acid

urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)-

CAS: 18449-41-7 C30 H48 O6 MW: 504.70776000

Identification

Namemadecassic acid
CAS Number18449-41-7
FDA UNIIM7O1N24J82
Molecular FormulaC30 H48 O6
Molecular Weight504.70776000
MDL NumberMFCD00895441
Nikkaji NumberJ39.267G

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 641.65 °C. @ 760.00 mm Hg (est)
Flash Point 673.00 °F. TCC ( 355.90 °C. ) (est)
logP (o/w) 4.321 (est)
Soluble in water, 0.9738 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for madecassic acid usage levels up tonot for fragrance use.
Recommendation for madecassic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

guava fruit pennywort asiatic pennywort

Synonyms

brahmic acid (1S,2R,4aS,6aR,6aS,6bR,8R,8aR,9R,10R,11R,12aR,14bS)-8,10,11- trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2a,3b,4a,6b)- PubMed: Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. PubMed: [Studies on fingerprints of Centella asiatica by HPLC]. PubMed: Two new triterpene glycosides from Centella asiatica. PubMed: Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation. PubMed: Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. PubMed: Centella asiatica in dermatology: an overview. PubMed: Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. PubMed: [Simultaneous determination of madecassoside,asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC]. PubMed: Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs. PubMed: Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. PubMed: Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts. PubMed: Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. PubMed: Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. PubMed: [Studies on fingerprints of Centella asiatica by HPLC]. PubMed: Triterpene composition and bioactivities of Centella asiatica. PubMed: Two new triterpene glycosides from Centella asiatica. PubMed: Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. PubMed: Conversion of alpha-amyrin into centellosides by plant cell cultures of Centella asiatica. PubMed: Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. PubMed: An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE). PubMed: Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica. PubMed: Association (micellization) and partitioning of aglycon triterpenoids. PubMed: Incorporation of triterpenic derivatives within an o/w/o multiple emulsion: structure and release studies. PubMed: Molecular dynamics simulation and thermodynamic modeling of the self-assembly of the triterpenoids asiatic acid and madecassic acid in aqueous solution. PubMed: [Separation and determination of madecassic acid in triterpenic genins of Centella asiatica by high performance liquid chromatography using beta-cyclodextrin as mobile phase additive]. PubMed: Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. PubMed: Advanced formulation and pharmacological activity of hydrogel of the titrated extract of C. asiatica. PubMed: Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. PubMed: An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products. PubMed: Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. PubMed: New innovations in scar management. PubMed: Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice. PubMed: Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. PubMed: Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban. PubMed: Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. PubMed: Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. PubMed: Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. PubMed: Contact dermatitis due to madecassol. PubMed: The metabolism of asiatic acid,-madecassic acid and asiaticoside in the rat.