madecassoside

O-6-deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate

CAS: 34540-22-2 C48 H78 O20 MW: 975.13366000

Identification

Namemadecassoside
CAS Number34540-22-2
EINECS252-076-1
FDA UNIICQ2F5O6YIY
Molecular FormulaC48 H78 O20
Molecular Weight975.13366000
MDL NumberMFCD00017380

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 1043.55 °C. @ 760.00 mm Hg (est)
Flash Point 564.00 °F. TCC ( 295.80 °C. ) (est)
logP (o/w) -1.338 (est)
Soluble in water, 18.13 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for madecassoside usage levels up tonot for fragrance use.
Recommendation for madecassoside flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

pennywort asiatic pennywort

Synonyms

O-6- deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate madecasoside PubMed: Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. PubMed: Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress. PubMed: Triterpene composition and bioactivities of Centella asiatica. PubMed: [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography]. PubMed: Molecular signalings in keloid disease and current therapeutic approaches from natural based compounds. PubMed: Morphological, chemical and molecular characterization of Centella asiatica germplasms for commercial cultivation in the Indo-Gangetic plains. PubMed: Protective effect of madecassoside against cognitive impairment induced by D-galactose in mice. PubMed: Optimization of madecassoside liposomes using response surface methodology and evaluation of its stability. PubMed: Separation mechanism of oleanane and ursane pentacyclic triterpenoid isomers by coordination chromatography. PubMed: Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. PubMed: Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. PubMed: An HPLC-MS/MS method for the quantitative determination of platycodin D in rat plasma and its application to the pharmacokinetics of Platycodi Radix extract. PubMed: Madecassoside prevents Aβ(25-35)-induced inflammatory responses and autophagy in neuronal cells through the class III PI3K/Beclin-1/Bcl-2 pathway. PubMed: Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice by downregulating collagen deposition. PubMed: Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation. PubMed: Centella asiatica in cosmetology. PubMed: In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb. PubMed: Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats. PubMed: [Near-infrared spectroscopy technology for online monitoring of the column separation and purification process of active components of Centella asiatica L. Urban]. PubMed: Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. PubMed: [Simultaneous determination of madecassoside,asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC]. PubMed: Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs. PubMed: Production of polyclonal antibody against madecassoside and development of immunoassay methods for analysis of triterpene glycosides in Centella asiatica. PubMed: Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. PubMed: Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts. PubMed: Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress. PubMed: Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways. PubMed: Discrimination of three Pegaga (Centella) varieties and determination of growth-lighting effects on metabolites content based on the chemometry of 1H nuclear magnetic resonance spectroscopy. PubMed: [Studies on fingerprints of Centella asiatica by HPLC]. PubMed: Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study. PubMed: Triterpene composition and bioactivities of Centella asiatica. PubMed: Preparation of a specific monoclonal antibody to asiaticoside for the development of an enzyme-linked immunosorbent assay. PubMed: Madecassoside suppresses LPS-induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. PubMed: Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. PubMed: Two new triterpene glycosides from Centella asiatica. PubMed: Contact dermatitis due to Centella asiatica. PubMed: Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. PubMed: Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. PubMed: An improved HPLC-UV method for the simultaneous quantification of triterpenic glycosides and aglycones in leaves of Centella asiatica (L.) Urb (APIACEAE). PubMed: [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography]. PubMed: Anti-rheumatoid arthritic effect of madecassoside on type II collagen-induced arthritis in mice. PubMed: Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica. PubMed: Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. PubMed: Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. PubMed: Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins. PubMed: Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat. PubMed: [Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo]. PubMed: Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection. PubMed: Enhanced production of asiaticoside from hairy root cultures of Centella asiatica (L.) Urban elicited by methyl jasmonate. PubMed: Identification of triterpenoid compounds of Centella asiatica by thin-layer chromatography and mass spectrometry. PubMed: Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban. PubMed: Hepatotoxicity associated with the ingestion of Centella asiatica. PubMed: [Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats]. PubMed: An improved HPLC method for quantitative determination of six triterpenes in Centella asiatica extracts and commercial products. PubMed: Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. PubMed: In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. PubMed: Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) urban.