chelerythrine hydrochloride

1,2-dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride

CAS: 3895-92-9 C21 H18 Cl N O4 MW: 383.83026000

Identification

Namechelerythrine hydrochloride
CAS Number3895-92-9
EINECS223-444-9
FDA UNII7IC98TZ0PZ
Molecular FormulaC21 H18 Cl N O4
Molecular Weight383.83026000
MDL NumberMFCD00060717

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-mouse LD50 18500 ug/kg
Dermal Toxicitysubcutaneous-mouse LD50 95 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for chelerythrine hydrochloride usage levels up tonot for fragrance use.
Recommendation for chelerythrine hydrochloride flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

celandine greater celandine

Synonyms

chelerythrine chloride chelerythrine HCl chelerythrine, chloride 1,2- dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride 1,2- dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride 1,2- dimethoxy-12-methyl-9H-phenanthridino[4',3'-5,4]benzo[d]1,3-dioxolane, chloride 1,2- dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride 1,2- dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride 1,2- dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride 1,2- dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c) phenanthridinium chloride 1,2- dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride PubMed: Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. PubMed: Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats. PubMed: Functional effects of β3-adrenoceptor on pacemaker activity in interstitial cells of Cajal from the mouse colon. PubMed: Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice. PubMed: Delta-opioid receptor activation promotes mesenchymal stem cell survival via PKC/STAT3 signaling pathway. PubMed: Role of mitochondrial ATP-sensitive potassium channels on fatigue in mouse muscle fibers. PubMed: Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone. PubMed: Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction. PubMed: l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons. PubMed: Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction. PubMed: Calcium channel and glutamate receptor activities regulate actin organization in salamander retinal neurons. PubMed: Purine release from spinal cord microglia after elevation of calcium by glutamate. PubMed: The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats. PubMed: Dopamine acutely decreases type 3 Na(+)/H(+) exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades. PubMed: Differential roles of spinal protein kinases C and a in development of primary heat and mechanical hypersensitivity induced by subcutaneous bee venom chemical injury in the rat. PubMed: Pharmacological characterisation of neuropeptide F (NPF)-induced effects on the motility of Mesocestoides corti (syn. Mesocestoides vogae) larvae. PubMed: Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes. PubMed: Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation. PubMed: Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium. PubMed: Rapid non-genomic inhibition of ATP-induced Cl- secretion by dexamethasone in human bronchial epithelium. PubMed: Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons. PubMed: Bradykinin-evoked Ca2+ mobilization in Madin Darby canine kidney cells. PubMed: Ca2+-independent protein kinase C isoforms may modulate parietal cell HCl secretion.