cyclovirobuxine D
bebuxine
Identification
| Name | cyclovirobuxine D |
| CAS Number | 860-79-7 |
| FDA UNII | 51GY352868 |
| Molecular Formula | C26 H46 N2 O |
| Molecular Weight | 402.66582000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 495.67 °C. @ 760.00 mm Hg (est) |
| Flash Point | 93.00 °F. TCC ( 34.10 °C. ) (est) |
| logP (o/w) | 4.635 (est) |
| Soluble in | water, 0.3869 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 9200 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
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Potential Uses
Natural Occurrence
Synonyms
bebuxine
9,19-
cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 4,4,14-trimethyl-3-beta,20-alpha-bis(methylamino)-
9,19-
cyclopregnan-16-ol, 4,4,14-trimethyl-3,20-bis(methylamino)-, (3beta,5alpha,16alpha,20S)-
cyclovirobuxin D
PubMed:
Cyclovirobuxine D Induces Autophagy-Associated Cell Death via the Akt/mTOR Pathway in MCF-7 Human Breast Cancer Cells.
PubMed:
Experimental and theoretical investigation on the interaction between cyclovirobuxine D and human serum albumin.
PubMed:
Influence of cyclovirobuxine D on intracellular [Ca(2+)] regulation and the expression of the calcium cycling proteins in rat myocytes.
PubMed:
[Effects of CVB-D on hemodynamic in anaesthetized dogs in vivo].
PubMed:
Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction.
PubMed:
Cyclovirobuxine D inhibits the currents of HERG potassium channels stably expressed in HEK293 cells.
PubMed:
[Studies of in vitro releasing properties on cyclovirobuxine D matrix-type patch].
PubMed:
Cyclovirobuxine D ameliorates acute myocardial ischemia by K(ATP) channel opening, nitric oxide release and anti-thrombosis.
PubMed:
Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens.
PubMed:
[Determination of cyclovirobuxine-D in huangyangning tablets by RP-HPLC with gradient elution].
PubMed:
Sensitive HPLC-APCI-MS method for the determination of cyclovirobuxine D in human plasma.
PubMed:
High performance liquid chromatography - tandem mass spectrometric determination of cyclovirobuxine D in human plasma.
PubMed:
[Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation].
PubMed:
[Prodrug structural modifications of cyclovirobuxine D and their biological activity].
PubMed:
Regulation of Ca2+ movements by cyclovirobuxine D in ECV304 endothelial cells.
PubMed:
[Electrophysiologic study of the biphasic effects of cyclovirobuxine D on arrhythmias].
PubMed:
[Effects of cyclovirobuxine D on intracellular Ca2+ and L-type Ca2+ current in rat ventricular cardiomyocytes].
PubMed:
[Structural modification and bioactivity of cyclovirobuxine D].
PubMed:
[Determination of cyclovirobuxine D by RP-HPLC with precolumn fluorescence derivatization].
PubMed:
Coronary effects of cyclovirobuxine D in anesthetized pigs and in isolated porcine coronary arteries.
PubMed:
Hemodynamic effects of the intravenous administration of cyclovirobuxine D [correction of cyclorirobuxine D] in anesthetized pigs.
PubMed:
[Anti-atrial fibrillation effects of cyclovirobuxine-D and its electrophysiological mechanism studied on guinea pig atria].
PubMed:
Protective effect of cycloprotobuxine-A against cardiac arrhythmias induced by ouabain.
PubMed:
[Congestive heart failure treated by a combination of cyclovirobuxine D with digoxin].
PubMed:
Anti-arrhythmic action of cycloprotobuxine-A.
PubMed:
The beneficial effects of cyclovirobuxine D (CVBD) in coronary heart disease. A double blind analysis of 110 cases.
PubMed:
[Double blind study of the therapeutic effect of cyclovirobuxine D No. 1 on the left ventricular function in coronary heart disease].
PubMed:
[Clinical observation of 546 cases of coronary heart disease treated with cyclovirobuxine D].
PubMed:
[Some cardiovascular effects of cyclovirobuxine-D (author's transl)].
PubMed:
[Experimental analysis of the anti-arrhythmic and arrhythmia-inducing actions of cyclovirobuxine D (author's transl)].