galantamine hydrobromide

(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide

CAS: 1953-04-4 C17 H22 Br N O3 MW: 368.27094000

Identification

Namegalantamine hydrobromide
CAS Number1953-04-4
EINECS217-780-5
FDA UNIIMJ4PTD2VVW
Molecular FormulaC17 H22 Br N O3
Molecular Weight368.27094000
MDL NumberMFCD00067672

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 439.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000000 mmHg @ 25.00 °C. (est)
Flash Point 427.00 °F. TCC ( 219.50 °C. ) (est)
logP (o/w) 1.750 (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for galantamine hydrobromide usage levels up tonot for fragrance use.
Recommendation for galantamine hydrobromide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

6H- benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide 6H- benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1) galanthamine bromhydrate (1:1) galanthamine HBr galanthamine hydrobromide galanthamine hydrobromide (1:1) galanthamine hydrobromide from lycoris sp. galanthamine hydrogen bromide galanthamine hydrogenbromide galanthaminehydrobromide galanthaminhydrobromid(1:1) lycoremine hydrobromide (4aS,6R,8aS)-3- methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide nivaline PubMed: Gypsogenin Derivatives: An Unexpected Class of Inhibitors of Cholinesterases. PubMed: Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry. PubMed: Benzophenones from Hypericum elegans with antioxidant and acetylcholinesterase inhibitory potential. PubMed: Synthesis of imperatorin analogs and their evaluation as acetylcholinesterase and butyrylcholinesterase inhibitors. PubMed: Quantification of galantamine in human plasma by validated liquid chromatography-tandem mass spectrometry using glimepride as an internal standard: application to bioavailability studies in 32 healthy Korean subjects. PubMed: Controlled release reservoir mini tablets approach for controlling the drug release of Galantamine Hydrobromide. PubMed: Development and in vivo evaluation of novel monolithic controlled release compositions of galantamine hydrobromide as against reservoir technology. PubMed: Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide. PubMed: The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome. PubMed: Galantamine is a novel post-exposure therapeutic against lethal VX challenge. PubMed: Bullous pemphigoid precipitated by galantamine hydrobromide. PubMed: Optimal dosing of galantamine in patients with mild or moderate Alzheimer's disease: post Hoc analysis of a randomized, double-blind, placebo-controlled trial. PubMed: A double-blind comparison of galantamine hydrobromide ER and placebo in Parkinson disease. PubMed: [Criminal clozapine intoxications]. PubMed: Pharmacokinetics and bioequivalence studies of galantamine hydrobromide dispersible tablet in healthy male Chinese volunteers. PubMed: Cholinesterase inhibitors in the treatment of dementia. PubMed: Capillary electrophoresis-mass spectrometry in impurity profiling of pharmaceutical products. PubMed: A prospective, double-blind, community-controlled comparison of three doses of galantamine in the treatment of mild to moderate Alzheimer's disease in a Korean population. PubMed: Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial. PubMed: The clinical efficacy and safety of galantamine in the treatment of Alzheimer's disease. PubMed: Pharmacokinetics and tissue distribution of galantamine and galantamine-related radioactivity after single intravenous and oral administration in the rat. PubMed: The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial. PubMed: Antioxidant properties of galantamine hydrobromide. PubMed: Galantamine hydrobromide: an agent for Alzheimer's disease. PubMed: Gateways to clinical trials. PubMed: Gateways to clinical trials. PubMed: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. PubMed: Gateways to Clinical Trials. June 2002. PubMed: Galantamine hydrobromide.