galantamine hydrobromide
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
Identification
| Name | galantamine hydrobromide |
| CAS Number | 1953-04-4 |
| EINECS | 217-780-5 |
| FDA UNII | MJ4PTD2VVW |
| Molecular Formula | C17 H22 Br N O3 |
| Molecular Weight | 368.27094000 |
| MDL Number | MFCD00067672 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 439.30 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point | 427.00 °F. TCC ( 219.50 °C. ) (est) |
| logP (o/w) | 1.750 (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for galantamine hydrobromide usage levels up to | not for fragrance use. |
| Recommendation for galantamine hydrobromide flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
6H-
benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide
6H-
benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)-, hydrobromide (1:1)
galanthamine bromhydrate (1:1)
galanthamine HBr
galanthamine hydrobromide
galanthamine hydrobromide (1:1)
galanthamine hydrobromide from lycoris sp.
galanthamine hydrogen bromide
galanthamine hydrogenbromide
galanthaminehydrobromide
galanthaminhydrobromid(1:1)
lycoremine hydrobromide
(4aS,6R,8aS)-3-
methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
nivaline
PubMed:
Gypsogenin Derivatives: An Unexpected Class of Inhibitors of Cholinesterases.
PubMed:
Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry.
PubMed:
Benzophenones from Hypericum elegans with antioxidant and acetylcholinesterase inhibitory potential.
PubMed:
Synthesis of imperatorin analogs and their evaluation as acetylcholinesterase and butyrylcholinesterase inhibitors.
PubMed:
Quantification of galantamine in human plasma by validated liquid chromatography-tandem mass spectrometry using glimepride as an internal standard: application to bioavailability studies in 32 healthy Korean subjects.
PubMed:
Controlled release reservoir mini tablets approach for controlling the drug release of Galantamine Hydrobromide.
PubMed:
Development and in vivo evaluation of novel monolithic controlled release compositions of galantamine hydrobromide as against reservoir technology.
PubMed:
Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide.
PubMed:
The effects of galantamine hydrobromide treatment on dehydroepiandrosterone sulfate and cortisol levels in patients with chronic fatigue syndrome.
PubMed:
Galantamine is a novel post-exposure therapeutic against lethal VX challenge.
PubMed:
Bullous pemphigoid precipitated by galantamine hydrobromide.
PubMed:
Optimal dosing of galantamine in patients with mild or moderate Alzheimer's disease: post Hoc analysis of a randomized, double-blind, placebo-controlled trial.
PubMed:
A double-blind comparison of galantamine hydrobromide ER and placebo in Parkinson disease.
PubMed:
[Criminal clozapine intoxications].
PubMed:
Pharmacokinetics and bioequivalence studies of galantamine hydrobromide dispersible tablet in healthy male Chinese volunteers.
PubMed:
Cholinesterase inhibitors in the treatment of dementia.
PubMed:
Capillary electrophoresis-mass spectrometry in impurity profiling of pharmaceutical products.
PubMed:
A prospective, double-blind, community-controlled comparison of three doses of galantamine in the treatment of mild to moderate Alzheimer's disease in a Korean population.
PubMed:
Effect of galantamine hydrobromide in chronic fatigue syndrome: a randomized controlled trial.
PubMed:
The clinical efficacy and safety of galantamine in the treatment of Alzheimer's disease.
PubMed:
Pharmacokinetics and tissue distribution of galantamine and galantamine-related radioactivity after single intravenous and oral administration in the rat.
PubMed:
The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial.
PubMed:
Antioxidant properties of galantamine hydrobromide.
PubMed:
Galantamine hydrobromide: an agent for Alzheimer's disease.
PubMed:
Gateways to clinical trials.
PubMed:
Gateways to clinical trials.
PubMed:
Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease.
PubMed:
Gateways to Clinical Trials. June 2002.
PubMed:
Galantamine hydrobromide.