gossypol acetate
(2,2'-binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-, hexaacetate
Identification
| Name | gossypol acetate |
| CAS Number | 30719-67-6 |
| FDA UNII | Search |
| Molecular Formula | C42 H42 O14 |
| Molecular Weight | 770.78554000 |
| Nikkaji Number | J126.058H |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 836.28 °C. @ 760.00 mm Hg (est) |
| Flash Point | 631.00 °F. TCC ( 332.90 °C. ) (est) |
| logP (o/w) | 5.028 (est) |
| Soluble in | water, 5.134e-008 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for gossypol acetate usage levels up to | not for fragrance use. |
| Recommendation for gossypol acetate flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
(2,2'-
binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-, hexaacetate
[2,2'-
binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexakis(acetyloxy)-3,3'-dimethyl-5,5'-bis(1-methylethyl)-
[3,8-
diacetyloxy-1-formyl-6-methyl-4-propan-2-yl-7-(1,6,7-triacetyloxy-8-formyl-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalen-2-yl] acetate
PubMed:
Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.
PubMed:
[Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone].
PubMed:
[Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line].
PubMed:
[Effect of liuwei dihuang decoction and its additives on boosting spermatogenesis in spermatogenesis obstruction rat].
PubMed:
In vitro effect of gossypol acetate on yellow perch (Perca flavescens) spermatozoa.
PubMed:
Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia).
PubMed:
[Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells].
PubMed:
Non-steroidal antifertility agents.
PubMed:
Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats.
PubMed:
Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells.
PubMed:
Effects of gossypol acetate on pituitary-adrenal axis in male albino rats.
PubMed:
[Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ].
PubMed:
[Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro].
PubMed:
Studies on mechanism(s) of antifertility action of gossypol in rat and hamster.
PubMed:
[Effect of gossypol acetate on the testicular HCG reactivity and its receptor in the rats].
PubMed:
Sites of action of gossypol studied by autoradiography and enzyme histochemistry.
PubMed:
Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships.
PubMed:
Inhibition of glycerolipid synthesis by gossypol acetate.
PubMed:
Cytogenetic analysis of a gossypol-induced murine myxosarcoma.
PubMed:
Antifertility treating with long term gossypol.
PubMed:
Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis.
PubMed:
[Gossypol acetate users].
PubMed:
[Synergic effects of gossypol acetate and sulphadiazine on the LDH-x activity and viability of human sperm].
PubMed:
Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro.
PubMed:
[Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes].
PubMed:
Gossypol-induced inhibition of guinea pig sperm capacitation in vitro.
PubMed:
[The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells].
PubMed:
[Effects of gossypol acetate on neuromuscular transmission (author's transl)].
PubMed:
Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats.
PubMed:
[The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)].