gossypol acetate

(2,2'-binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-, hexaacetate

CAS: 30719-67-6 C42 H42 O14 MW: 770.78554000

Identification

Namegossypol acetate
CAS Number30719-67-6
FDA UNIISearch
Molecular FormulaC42 H42 O14
Molecular Weight770.78554000
Nikkaji NumberJ126.058H

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 836.28 °C. @ 760.00 mm Hg (est)
Flash Point 631.00 °F. TCC ( 332.90 °C. ) (est)
logP (o/w) 5.028 (est)
Soluble in water, 5.134e-008 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for gossypol acetate usage levels up tonot for fragrance use.
Recommendation for gossypol acetate flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

(2,2'- binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-, hexaacetate [2,2'- binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexakis(acetyloxy)-3,3'-dimethyl-5,5'-bis(1-methylethyl)- [3,8- diacetyloxy-1-formyl-6-methyl-4-propan-2-yl-7-(1,6,7-triacetyloxy-8-formyl-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalen-2-yl] acetate PubMed: Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. PubMed: [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. PubMed: [Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. PubMed: [Effect of liuwei dihuang decoction and its additives on boosting spermatogenesis in spermatogenesis obstruction rat]. PubMed: In vitro effect of gossypol acetate on yellow perch (Perca flavescens) spermatozoa. PubMed: Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). PubMed: [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]. PubMed: Non-steroidal antifertility agents. PubMed: Histopathological and biochemical effects of gossypol acetate on pituitary-gonadal axis of male albino rats. PubMed: Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. PubMed: Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. PubMed: [Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ]. PubMed: [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. PubMed: Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. PubMed: [Effect of gossypol acetate on the testicular HCG reactivity and its receptor in the rats]. PubMed: Sites of action of gossypol studied by autoradiography and enzyme histochemistry. PubMed: Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. PubMed: Inhibition of glycerolipid synthesis by gossypol acetate. PubMed: Cytogenetic analysis of a gossypol-induced murine myxosarcoma. PubMed: Antifertility treating with long term gossypol. PubMed: Morphologic and endocrine changes in the reproductive organs in rats implanted with gossypol acetate pellet in the testis. PubMed: [Gossypol acetate users]. PubMed: [Synergic effects of gossypol acetate and sulphadiazine on the LDH-x activity and viability of human sperm]. PubMed: Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro. PubMed: [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes]. PubMed: Gossypol-induced inhibition of guinea pig sperm capacitation in vitro. PubMed: [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. PubMed: [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. PubMed: Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. PubMed: [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)].