salvia miltiorrhiza flower/leaf/root extract
extract of the roots, flowers and leaves of the chinese sage, salvia miltiorrhiza, lamiaceae
Identification
| Name | salvia miltiorrhiza flower/leaf/root extract |
| IUPAC | salvia miltiorhiza flower/leaf/root extract |
| CAS Number | 90106-50-6 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for salvia miltiorrhiza flower/leaf/root extract usage levels up to | not for fragrance use. |
| Recommendation for salvia miltiorrhiza flower/leaf/root extract flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
extract of the roots, flowers and leaves of the chinese sage, salvia miltiorrhiza, lamiaceae
chinese
sage flower/leaf/root extract
salvia miltiorhiza flower/leaf/root extract
PubMed:
Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: enzyme kinetic and molecular docking studies.
PubMed:
Comprehensive multi-channel multi-dimensional counter-current chromatography for separation of tanshinones from Salvia miltiorrhiza Bunge.
PubMed:
Salvia miltiorrhiza (Danshen) injection ameliorates iron overload-induced cardiac damage in mice.
PubMed:
Danshen (Salvia miltiorrhiza) injection suppresses kidney injury induced by iron overload in mice.
PubMed:
Aqueous extract of danshen (Salvia miltiorrhiza Bunge) protects ovariectomized rats fed with high-fat diet from endothelial dysfunction.
PubMed:
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
PubMed:
Competitive inhibition of human organic anion transporters 1 (SLC22A6), 3 (SLC22A8) and 4 (SLC22A11) by major components of the medicinal herb Salvia miltiorrhiza (Danshen).
PubMed:
Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats.
PubMed:
Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials.
PubMed:
Extract of Salvia miltiorrhiza (Danshen) induces Nrf2-mediated heme oxygenase-1 expression as a cytoprotective action in RAW 264.7 macrophages.
PubMed:
Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats.
PubMed:
[Effects of danshen injection on the proliferation of rheumatoid arthritis fibroblast-like synoviocytes cultured with human serum].
PubMed:
Effects of the aqueous extract of Salvia Miltiorrhiza (danshen) and its magnesium tanshinoate B-enriched form on blood pressure.
PubMed:
Optimization of liquid chromatographic method for the separation of nine hydrophilic and hydrophobic components in Salviae miltiorrhizae Radix et Rhizoma (Danshen) using microemulsion as eluent.
PubMed:
Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion.
PubMed:
Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen).
PubMed:
Postmarketing safety evaluation: depside salt injection made from Danshen (Radix Salviae Miltiorrhizae).
PubMed:
Molecular evidence of cryptotanshinone for treatment and prevention of human cancer.
PubMed:
A simple and reliable method for distinguishing danshen in salvia: simultaneous quantification of six active compositions by HPLC.
PubMed:
Danshen (Salvia miltiorrhiza) extract inhibits proliferation of breast cancer cells via modulation of Akt activity and p27 level.
PubMed:
The role of traditional Chinese medicines in osteogenesis and angiogenesis.
PubMed:
Effects of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates.
PubMed:
Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats.
PubMed:
[Study on "multi-dimensional structure and process dynamics quality control system" of Danshen infusion solution based on component structure theory].
PubMed:
Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926 cells.
PubMed:
[Determination of the allergic impurities in the parenteral injection of Chinese traditional medicines containing Salvia miltiorrhiza].
PubMed:
Investigation of the absorbed and metabolized components of Danshen from Fuzheng Huayu recipe and study on the anti-hepatic fibrosis effects of these components.
PubMed:
[Effects of danshen on NO and ET-1 secreted by endothelial cells induced by the serum of pre-eclampsia patients].
PubMed:
[Experimental study on anti-atherosclerotic effect of compatibility of active components of danshen and shanzha].
PubMed:
Monitoring batch-to-batch reproducibility using direct analysis in real time mass spectrometry and multivariate analysis: a case study on precipitation.
PubMed:
[Experimental study on anaphylactoid reactions of guinea pig induced by danshen injection and its components].
PubMed:
Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture.
PubMed:
[Analysis on patent network of compound Danshen extracts built by Tasly].
PubMed:
Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins.
PubMed:
[Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits].
PubMed:
[Effect of compound danshen dripping pill combined with intravenous transplantation of human umbilical cord blood mononuclear cells on local inflammatory response in the myocardium of rabbits with acute myocardial infarction].
PubMed:
Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection.
PubMed:
[Regulatory roles of compound danshen in the downstream path of cyclooxygenases in rheumatoid arthritis patients' synovium].
PubMed:
[Meta-analysis on impact of Danshen on liver regeneration in rats].
PubMed:
Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities.
PubMed:
[Study on fingerprint chromatograms of water-soluble constituents of Salvia miltiorrhiza Bge. by high performance liquid chromatography].
PubMed:
[Multistage multivariate statistic quality control (MMSQC) for monitoring production process of traditional Chinese medicines].
PubMed:
Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts.
PubMed:
Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia.
PubMed:
Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.
PubMed:
Chinese herbal medicine Danshen formulations for preventing renal disease in Henoch-Schönlein Purpura: a systematic review and meta-analysis.
PubMed:
Quality by design for herbal drugs: a feedforward control strategy and an approach to define the acceptable ranges of critical quality attributes.
PubMed:
Evaluation of cardiomyocyte hypoxia injury models for the pharmacological study in vitro.
PubMed:
Effect of danshen on the zero-stress state of rat's abdominal aorta.
PubMed:
A system-level investigation into the mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for cardiovascular disease treatment.
PubMed:
A target analogue imprinted polymer for the recognition of antiplatelet active ingredients in Radix Salviae Miltiorrhizae by LC/MS/MS.
PubMed:
Protective and antioxidant effect of Danshen polysaccharides on cerebral ischemia/reperfusion injury in rats.
PubMed:
Enhanced antioxidant bioactivity of Salvia miltiorrhiza (Danshen) products prepared using nanotechnology.
PubMed:
Direct vasorelaxation by a novel phytoestrogen tanshinone IIA is mediated by nongenomic action of estrogen receptor through endothelial nitric oxide synthase activation and calcium mobilization.
PubMed:
Acute treatment with Danshen-Gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive PKCÉ/mK(ATP) pathway in rats.
PubMed:
Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza).
PubMed:
Effects of the aqueous extract from Salvia miltiorrhiza Bge on the pharmacokinetics of diazepam and on liver microsomal cytochrome P450 enzyme activity in rats.
PubMed:
[Medicinal plants in the phytotherapy of alcohol or nicotine addiction. Implication for plants in vitro cultures].
PubMed:
Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways.
PubMed:
Danshen diversity defeating dementia.
PubMed:
[Effect of Salvia miltiorrhiza on the left ventricular diastolic function in coronary artery stenosis].
PubMed:
[Experimental study on myocardial protection with verapamil and salvia miltiorrhiza Bunge cardioplegia].
PubMed:
Magnetic screening of the potential targeted protein of salvianolic acid B using T7 phage display library.
PubMed:
Interaction between warfarin and danshen (Salvia miltiorrhiza).
PubMed:
[Effect of salvia miltiorrhiza composita on superoxide dismutase and malonyldialdehyde in treating patients with non-insulin dependent diabetes mellitus (NIDDM)].
PubMed:
[Effect of Salvia miltiorrhiza on the cardial ischemia in rats induced by ligation].
PubMed:
[Protective effects of nerve growth factor vs Danshen on hippocampal neuron against global ischemia-reperfusion injury in gerbils].
PubMed:
[Prevention of radiation injury of the lungs by Salvia miltiorrhiza in mice].
PubMed:
[Effects of Danshen injection on glial cell line-derived neurotrophic factor mRNA of acute spinal cord injury rats and its mechanisms].
PubMed:
[Effects of different administration of Salvia miltiorrhiza and heparin on antithrombin IIIAg, antithrombin III: A and alpha 2-macroglobulin in patients with cor pulmonale].
PubMed:
[Protective mechanism of Salvia miltiorrhiza and Paeonia lactiflora for experimental liver damage].
PubMed:
[Protective action of Salvia miltiorrhiza aqueous extract on chemically induced acute myocardial ischemia in rats].
PubMed:
The effects of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats.
PubMed:
[Prevention and treatment of isoproterenol induced ventricular fibrillation in rats by aqueous extract of Salvia miltiorrhiza].
PubMed:
[Effect of Salvia miltiorrhiza co. on angiotensin II and atrial natriuretic polypeptide in rabbits].
PubMed:
Mechanism of protective effects of Danshen against iron overload-induced injury in mice.
PubMed:
Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats.
PubMed:
[Effect of compound danshen dripping pill on arterial intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus].
PubMed:
Microsphere resin chromatography combined with microbial biotransformation for the separation and purification of salvianolic acid B in aqueous extract of roots of Salvia multiorrihza Bunge.
PubMed:
[The protective effects of Salvia miltiorrhiza on the warm ischemic kidney: experimental study in animals].
PubMed:
[Quality evaluation of cultivated Salvia miltiorrhiza Bge. in Chongming, a suburb of Shanghai].
PubMed:
[Dilative effect of injection of radix Angelicae, Salvia miltiorrhiza and ligustrazin on the pulmonary vessels in rats].
PubMed:
[Effect of Salvia miltiorrhiza on the survival time of a heart allograft in experimental animals].
PubMed:
[Effect of Liqustrazini and Salvia miltiorrhiza on extracorporeal fibroblast culture].
PubMed:
[Effect of ligustrazine and salvia miltiorrhiza on microcirculation in the hamster cheek pouch].
PubMed:
[Effect of Salvia miltiorrhiza on mesenteric microcirculatory blood flow in the dog measured by the Doppler effect of laser light].
PubMed:
[Effect of Salvia miltiorrhiza root on calcium deposition in experimental fracture healing].
PubMed:
The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats.
PubMed:
[Platelet aggregation inhibitors from Salvia miltiorrhiza Bunge].
PubMed:
[Effect of Salvia miltiorrhiza on hyperfibrinogen in patients with malignant lymphoma].
PubMed:
[Clinical and experimental study on the effect of Salvia miltiorrhiza on microcirculation and 2,3 diphosphoglyceric acid in patients with coronary heart disease].
PubMed:
[Changes in plasma 6-keto-PGF1 alpha, TXB2 lipid peroxides in acute cerebral infarction patients and the effects of Salvia miltiorrhiza on these three indices].
PubMed:
[Reversed phase HPLC determination of three components in Salvia miltiorrhiza injections].
PubMed:
[Water soluble constituents from radix Salvia miltiorrhiza before and after slicing].
PubMed:
[The structure of dan-shen spiroketallactone of dan-shen (Salvia miltiorrhiza Bunge)].
PubMed:
[Pharmacology of Salvia miltiorrhiza].
PubMed:
[Effect of Salvia miltiorrhiza on experimental hepatic regeneration].
PubMed:
[The relationship between root growth and cryptotanshinone content of Salvia miltiorrhiza].
PubMed:
[Studies on the chemical components of Dan-shen (Salvia miltiorrhiza Bunge) (author's transl)].
PubMed:
Pharmacological studies on the sedative-hypnotic effect of Semen Ziziphi spinosae (Suanzaoren) and Radix et Rhizoma Salviae miltiorrhizae (Danshen) extracts and the synergistic effect of their combinations.
PubMed:
The quality of randomized controlled trials on DanShen in the treatment of ischemic vascular disease.
PubMed:
Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery.
PubMed:
[Effect of the mixed liquor of danshen and magnesium sulfate injection on IgG and IgM in serum of rabbits with lumbar intervertebral disc herniation].
PubMed:
Rapid and sensitive analysis of multiple bioactive constituents in Compound Danshen preparations using LC-ESI-TOF-MS.
PubMed:
Long-term treatment with danshen-gegen decoction protects the myocardium against ischemia/reperfusion injury via the redox-sensitive protein kinase C-ε/mK(ATP) pathway in rats.
PubMed:
The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero.
PubMed:
Mechanisms of the relaxant effect of a danshen and gegen formulation on rat isolated cerebral basilar artery.
PubMed:
Simultaneous determination of seven active components of Fufang Danshen tablet by high performance liquid chromatography.
PubMed:
Pharmacokinetic study of salvianolic acid A in rat after intravenous administration of Danshen injection.
PubMed:
Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis.
PubMed:
Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis.
PubMed:
Structural elucidation of metabolites of tanshinone I and its analogue dihydrotanshinone I in rats by HPLC-ESI-MSn.
PubMed:
[Effect of a compound Danshen preparation in preventing long-term gastric lipid emulsion administration-induced nonalcoholic steatohepatitis in rats].
PubMed:
Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use.
PubMed:
Danshen (Chinese medicinal herb) preparations for acute myocardial infarction.
PubMed:
[Clinical study of diabetic retinopathy treated by compound danshen dripping pills].
PubMed:
Danshen prevents the occurrence of oxidative stress in the eye and aorta of diabetic rats without affecting the hyperglycemic state.
PubMed:
Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers.
PubMed:
Simultaneous determination of magnesium lithospermate B, rosmarinic acid, and lithospermic acid in beagle dog serum by liquid chromatography/tandem mass spectrometry.
PubMed:
Salvinal, a novel microtubule inhibitor isolated from Salvia miltiorrhizae Bunge (Danshen), with antimitotic activity in multidrug-sensitive and -resistant human tumor cells.
PubMed:
[Effect of Danshen root compound on blood lipid and bone biomechanics in mice with hyperlipemia-induced osteoporosis].
PubMed:
Simultaneous determination and pharmacokinetic study of water-soluble and lipid-soluble components of danshen in rat plasma using HPLC-UV method.
PubMed:
Impaired protein binding of Chinese medicine DanShen in uremic sera and sera with hyperbilirubinemia: rapid assessment of total and free DanShen concentrations using the fluorescence polarization immunoassay for digoxin.
PubMed:
Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo.
PubMed:
[Identification of Panax notoginseng and its preparations by LC/MS].
PubMed:
[Stromal cells from human Wharton's jelly differentiate into neural cells].
PubMed:
A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes.
PubMed:
Immunomodulatory effects of yun zhi and danshen capsules in health subjects--a randomized, double-blind, placebo-controlled, crossover study.
PubMed:
[Studies and preparations of fufang danshen granules].
PubMed:
[Effects of Chinese materia medica in activating blood and stimulating menstrual flow on the endocrine function of ovary-uterus and its mechanisms].
PubMed:
Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation.
PubMed:
[Use of amphotericin B-cells to detect inhibitors of cellular cholesterol biosynthesis].
PubMed:
[Identification of tanshinones with related compounds by high performance thin layer chromatography and mass spectrometric analysis].