baicalin
5,6,7-trihydroxyflavone 7-O-b-D-glucuronide
Identification
| Name | baicalin |
| CAS Number | 21967-41-9 |
| FDA UNII | 347Q89U4M5 |
| Molecular Formula | C21 H18 O11 |
| Molecular Weight | 446.36566000 |
| MDL Number | MFCD00134418 |
| Nikkaji Number | J94.473D |
| Beilstein | 070480 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 836.62 °C. @ 760.00 mm Hg (est) |
| Flash Point | 567.00 °F. TCC ( 297.20 °C. ) (est) |
| logP (o/w) | 1.431 (est) |
| Soluble in | water, 907 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants, skin conditioning |
| Recommendation for baicalin usage levels up to | not for fragrance use. |
| Recommendation for baicalin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
baicalein-7-D-glucuronide
4H-1-
benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-phenyl-
5,6-
dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid
(2S,3S,4S,5R,6S)-6-((5,6-
dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
(2S,3S,4S,5R,6S)-6-(5,6-
dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
5,6,7-
trihydroxyflavone 7-O-b-D-glucuronide
5,6,7-
trihydroxyflavone-7-O-b-D-glucopyranosideuronic acid
PubMed:
Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats.
PubMed:
[Effect of different developmental stage on plant growth and active compounds in Scutellaria baicalensis].
PubMed:
Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia.
PubMed:
Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization.
PubMed:
Baicalin Inhibits the Lethality of Shiga-Like Toxin 2 in Mice.
PubMed:
The effect of baicalin in a mouse model of retinopathy of prematurity.
PubMed:
Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation.
PubMed:
Purification and antioxidant activities of baicalin isolated from the root of huangqin (Scutellaria baicalensis gcorsi).
PubMed:
Inhibitory effect of baicalin and baicalein on ovarian cancer cells.
PubMed:
The role of intestinal microflora in anti-inflammatory effect of baicalin in mice.
PubMed:
Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin.
PubMed:
Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.
PubMed:
Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles.
PubMed:
Variation of pathways and network profiles reveals the differential pharmacological mechanisms of each effective component to treat middle cerebral artery ischemia-reperfusion mice.
PubMed:
Spectroscopic investigation on the food components-drug interaction: the influence of flavonoids on the affinity of nifedipine to human serum albumin.
PubMed:
Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats.
PubMed:
Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats.
PubMed:
Baicalin in radical scavenging and its synergistic effect with beta-carotene in antilipoxidation.
PubMed:
A Scutellaria baicalensis radix water extract inhibits morphine-induced conditioned place preference.
PubMed:
Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts.
PubMed:
Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats.
PubMed:
Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series.
PubMed:
Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits.
PubMed:
Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell.
PubMed:
Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress.
PubMed:
Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats.
PubMed:
Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:
Identification of a nitric oxide generation-stimulative principle in Scutellariae radix.
PubMed:
Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke.
PubMed:
Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury.
PubMed:
Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis.
PubMed:
HPLC and chemometrics for the quality consistency evaluation of Shuanghuanglian injection.
PubMed:
Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley rats.
PubMed:
Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells.
PubMed:
Wnt signaling in liver fibrosis: progress, challenges and potential directions.
PubMed:
Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi.
PubMed:
Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response.
PubMed:
Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods.
PubMed:
90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats.
PubMed:
Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity.
PubMed:
Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
PubMed:
Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay.
PubMed:
Rapid in vivo screening system for anti-oxidant activity using bacterial redox sensor strains.
PubMed:
An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix.
PubMed:
[Intestinal absorption and secretion mechanism of carboxylate drugs].
PubMed:
Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis.
PubMed:
Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.
PubMed:
Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats.
PubMed:
Effect of Sho-saiko-to extract on HGF and TGF-beta levels of intraorgans in liver-injured rats after partial hepatectomy.
PubMed:
Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes.
PubMed:
Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed:
A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation.
PubMed:
Glycosylation of dietary flavonoids decreases the affinities for plasma protein.
PubMed:
Development of the chromatographic fingerprint of herbal preparations Shuang-Huang-Lian oral liquid.
PubMed:
Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells.
PubMed:
Ultrasound-assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang.