5,6,7-trihydroxyflavone 7-O-b-D-glucuronide

CAS: 21967-41-9 C21 H18 O11 MW: 446.36566000

Identification

Namebaicalin
CAS Number21967-41-9
FDA UNII347Q89U4M5
Molecular FormulaC21 H18 O11
Molecular Weight446.36566000
MDL NumberMFCD00134418
Nikkaji NumberJ94.473D
Beilstein070480

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 836.62 °C. @ 760.00 mm Hg (est)
Flash Point 567.00 °F. TCC ( 297.20 °C. ) (est)
logP (o/w) 1.431 (est)
Soluble in water, 907 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants, skin conditioning
Recommendation for baicalin usage levels up tonot for fragrance use.
Recommendation for baicalin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

skullcap baikal skullcap

Synonyms

baicalein-7-D-glucuronide 4H-1- benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,6-dihydroxy-2-phenyl- 5,6- dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid (2S,3S,4S,5R,6S)-6-((5,6- dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (2S,3S,4S,5R,6S)-6-(5,6- dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid 5,6,7- trihydroxyflavone 7-O-b-D-glucuronide 5,6,7- trihydroxyflavone-7-O-b-D-glucopyranosideuronic acid PubMed: Novel pharmacokinetic studies of the Chinese formula Huang-Lian-Jie-Du-Tang in MCAO rats. PubMed: [Effect of different developmental stage on plant growth and active compounds in Scutellaria baicalensis]. PubMed: Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia. PubMed: Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization. PubMed: Baicalin Inhibits the Lethality of Shiga-Like Toxin 2 in Mice. PubMed: The effect of baicalin in a mouse model of retinopathy of prematurity. PubMed: Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation. PubMed: Purification and antioxidant activities of baicalin isolated from the root of huangqin (Scutellaria baicalensis gcorsi). PubMed: Inhibitory effect of baicalin and baicalein on ovarian cancer cells. PubMed: The role of intestinal microflora in anti-inflammatory effect of baicalin in mice. PubMed: Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin. PubMed: Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. PubMed: Rapid magnetic solid-phase extraction for the selective determination of isoflavones in soymilk using baicalin-functionalized magnetic nanoparticles. PubMed: Variation of pathways and network profiles reveals the differential pharmacological mechanisms of each effective component to treat middle cerebral artery ischemia-reperfusion mice. PubMed: Spectroscopic investigation on the food components-drug interaction: the influence of flavonoids on the affinity of nifedipine to human serum albumin. PubMed: Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats. PubMed: Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats. PubMed: Baicalin in radical scavenging and its synergistic effect with beta-carotene in antilipoxidation. PubMed: A Scutellaria baicalensis radix water extract inhibits morphine-induced conditioned place preference. PubMed: Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts. PubMed: Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats. PubMed: Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. PubMed: Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. PubMed: Baicalin induces differential expression of cytochrome C oxidase in human lung H441 cell. PubMed: Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress. PubMed: Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. PubMed: Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. PubMed: Identification of a nitric oxide generation-stimulative principle in Scutellariae radix. PubMed: Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke. PubMed: Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury. PubMed: Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis. PubMed: HPLC and chemometrics for the quality consistency evaluation of Shuanghuanglian injection. PubMed: Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley rats. PubMed: Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells. PubMed: Wnt signaling in liver fibrosis: progress, challenges and potential directions. PubMed: Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. PubMed: Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. PubMed: Stabilization of anthocyanin and skullcap flavone complexes--investigations with computer simulation and experimental methods. PubMed: 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. PubMed: Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. PubMed: Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. PubMed: Screening and quantitative analysis of antioxidants in the fruits of Livistona chinensis R. Br using HPLC-DAD-ESI/MS coupled with pre-column DPPH assay. PubMed: Rapid in vivo screening system for anti-oxidant activity using bacterial redox sensor strains. PubMed: An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix. PubMed: [Intestinal absorption and secretion mechanism of carboxylate drugs]. PubMed: Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. PubMed: Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products. PubMed: Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats. PubMed: Effect of Sho-saiko-to extract on HGF and TGF-beta levels of intraorgans in liver-injured rats after partial hepatectomy. PubMed: Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes. PubMed: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. PubMed: A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. PubMed: Glycosylation of dietary flavonoids decreases the affinities for plasma protein. PubMed: Development of the chromatographic fingerprint of herbal preparations Shuang-Huang-Lian oral liquid. PubMed: Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. PubMed: Ultrasound-assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang.