hypericin
cyclosan
Identification
| Name | hypericin |
| CAS Number | 548-04-9 |
| EINECS | 208-941-0 |
| FDA UNII | 7V2F1075HD |
| Molecular Formula | C30 H16 O8 |
| Molecular Weight | 504.45112000 |
| MDL Number | MFCD00016683 |
| Nikkaji Number | J6.443B |
| Beilstein | 1917913 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 1020.33 °C. @ 760.00 mm Hg (est) |
| Flash Point | 1084.00 °F. TCC ( 584.60 °C. ) (est) |
| logP (o/w) | 10.827 (est) |
| Soluble in | water, 6.262e-006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for hypericin usage levels up to | not for fragrance use. |
| Recommendation for hypericin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
cyclo werrol
cyclo-werol
cyclosan
1,3,4,6,8,13-
hexahydroxy-10,11-dimethyl-phenanthro[1,10,9,8-opqra]perylene-7,14-dione
1,3,4,6,8,13-
hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione
1,3,4,6,8,13-
hexahydroxy-10,11-diméthylphénanthro[1,10,9,8-opqra]pérylène-7,14-dione
4,5,7,4',5',7'-
hexahydroxy-2,2'-dimethyl-mesonapthtodianthron
4,4',5,5',7,7'-
hexahydroxy-2,2'-dimethylnaphthodianthrone
4,5,7,4',5',7'-
hexahydroxy-2,2'-dimethylnaphthodianthrone
hypericine
hypericum red
phenanthro[1,10,9,8-opqra]perylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-
vimrxyn
PubMed:
St. John's wort reversal of meningeal nociception: A natural therapeutic perspective for migraine pain.
PubMed:
Do Other Hypericum Species Have Medical Potential As St. John's Wort (Hypericum perforatum)?
PubMed:
[Chemical constituents from Hypericum perforatum].
PubMed:
Pilot-scale culture of hypericum perforatum L. Adventitious roots in airlift bioreactors for the production of bioactive compounds.
PubMed:
Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract.
PubMed:
Improvement of hairy root cultures and plants by changing biosynthetic pathways leading to pharmaceutical metabolites: Strategies and applications.
PubMed:
Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of Hypericum perforatum and their LC-DAD-MS analyses.
PubMed:
Between species diversity of Hypericum perforatum and H. maculatum by the content of bioactive compounds.
PubMed:
Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light.
PubMed:
Plant-derived bioactive compounds produced by endophytic fungi.
PubMed:
Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport.
PubMed:
Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments.
PubMed:
Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast.
PubMed:
Bioactive constituent production in St. John's Wort in vitro hairy roots. Regenerated plant lines.
PubMed:
Hypericin and hyperforin production in St. John's wort in vitro culture: influence of saccharose, polyethylene glycol, methyl jasmonate, and Agrobacterium tumefaciens.
PubMed:
Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds.
PubMed:
Comparison of methods for the exhaustive extraction of hypericins, flavonoids, and hyperforin from Hypericum perforatum L.
PubMed:
Approach to novel functional foods for stress control 4. Regulation of serotonin transporter by food factors.
PubMed:
Herbal drug quality and phytochemical composition of Hypericum perforatum L. affected by ash yellows phytoplasma infection.
PubMed:
The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms.
PubMed:
Liquid chromatographic determination of St. John's wort components in functional foods.
PubMed:
Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage.
PubMed:
Clinic at the health food store? Employee recommendations and product analysis.
PubMed:
Determination of St. John's wort components in dietary supplements and functional foods by liquid chromatography.
PubMed:
Impact of hypericum (St.-John's-wort) given prenatally on cognition of mice offspring.
PubMed:
Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin.
PubMed:
Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats.
PubMed:
Optimization of extraction conditions for active components in Hypericum perforatum using response surface methodology.
PubMed:
Effects of Hypericum perforatum extraction on alcohol intake in Marchigian Sardinian alcohol-preferring rats.
PubMed:
Toxins in chrysomelid beetles Possible evolutionary sequence from de novo synthesis to derivation from food-plant chemicals.