gymnemic acid
Identification
| Name | gymnemic acid |
| CAS Number | 1399-64-0 |
| FDA UNII | 327O38FRK1 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for gymnemic acid usage levels up to | not for fragrance use. |
| Recommendation for gymnemic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
gymnemic acid
PubMed:
Abiotic elicitation of gymnemic acid in the suspension cultures of Gymnema sylvestre.
PubMed:
Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar).
PubMed:
[Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult].
PubMed:
In vivo anti-ulcer, anti-stress, anti-allergic, and functional properties of gymnemic acid isolated from Gymnema sylvestre R Br.
PubMed:
A systematic review of Gymnema sylvestre in obesity and diabetes management.
PubMed:
Gymnemic acids inhibit hyphal growth and virulence in Candida albicans.
PubMed:
Effect of a deacyl gymnemic acid on glucose homeostasis & metabolic parameters in a rat model of metabolic syndrome.
PubMed:
Abiotic elicitation of gymnemic acid in the suspension cultures of Gymnema sylvestre.
PubMed:
Anti-apoptotic potential of gymnemic acid phospholipid complex pretreatment in Wistar rats with experimental cardiomyopathy.
PubMed:
Production of gymnemic acid depends on medium, explants, PGRs, color lights, temperature, photoperiod, and sucrose sources in batch culture of Gymnema sylvestre.
PubMed:
Protective effect of herbomineral formulation (Dolabi) on early diabetic nephropathy in streptozotocin-induced diabetic rats.
PubMed:
Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar).
PubMed:
In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats.
PubMed:
A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats.
PubMed:
In vitro production of gymnemic acid from Gymnema sylvestre (Retz) R. Br. ex roemer and schultes through callus culture under abiotic stress conditions.
PubMed:
Gymnemic acid interacts with mammalian glycerol-3-phosphate dehydrogenase.
PubMed:
Extraction and quantification of gymnemic acids through gymnemagenin from callus cultures of Gymnema sylvestre.
PubMed:
Standardisation of Gymnema sylvestre R.Br. by high-performance thin-layer chromatography: an improved method.
PubMed:
Decreased bodyweight without rebound and regulated lipoprotein metabolism by gymnemate in genetic multifactor syndrome animal.
PubMed:
Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions.
PubMed:
Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control.
PubMed:
Interaction of gymnemic acid with cyclodextrins analyzed by isothermal titration calorimetry, NMR and dynamic light scattering.
PubMed:
[Advances in the study on hypoglycemic constituents of Gymnema sylvestre (Retz.) Schult].
PubMed:
An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents.
PubMed:
Inhibitory effect of voglibose and gymnemic acid on maltose absorption in vivo.
PubMed:
Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestine.
PubMed:
Caloric restriction in primates and relevance to humans.
PubMed:
Structure-activity relationships of triterpenoid derivatives extracted from Gymnema inodorum leaves on glucose absorption.
PubMed:
Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice.
PubMed:
Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability.
PubMed:
Taste confusions following gymnemic acid rinse.
PubMed:
Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves.
PubMed:
Inhibitory effect of gymnemic acid on intestinal absorption of oleic acid in rats.
PubMed:
Taste in chimpanzees. III: Labeled-line coding in sweet taste.
PubMed:
Influence of sweet suppressing agent on gustatory brain evoked potentials generated by taste stimuli.
PubMed:
Sweet and sweetness-inducing activities of new triterpene glycosides, strogins.
PubMed:
Medicinal foodstuffs. X. Structures of new triterpene glycosides, gymnemosides-c, -d, -e, and -f, from the leaves of Gymnema sylvestre R. Br.: influence of gymnema glycosides on glucose uptake in rat small intestinal fragments.
PubMed:
Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of Gymnema sylvestre R. BR. (Asclepiadaceae): structures of gymnemosides a and b.
PubMed:
Suppression of glucose absorption by some fractions extracted from Gymnema sylvestre leaves.
PubMed:
Taste in chimpanzee: I. The summated response to sweeteners and the effect of gymnemic acid.
PubMed:
New hypoglycemic constituents in "gymnemic acid" from Gymnema sylvestre.
PubMed:
An extract of Gymnema sylvestre leaves and purified gymnemic acid inhibits glucose-stimulated gastric inhibitory peptide secretion in rats.
PubMed:
Isolation and structure elucidation of gymnemic acids, antisweet principles of Gymnema sylvestre.
PubMed:
Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteins.
PubMed:
On the taste of umami in chimpanzee.
PubMed:
Binding proteins for sweet compounds from gustatory papillae of the cow, pig and rat.
PubMed:
Effects of gymnemic acid on the chorda tympani proper nerve responses to sweet, sour, salty and bitter taste stimuli in the chimpanzee.
PubMed:
Sweet taste receptor mechanisms.
PubMed:
Studies on snake venom enzymes: Part II--Partial characterization of ATPases from Russell's viper (Vipera russelli) venom & their interaction with potassium gymnemate.
PubMed:
Studies on snake venom enzymes: Part I. Purification of ATPase, a toxic component of Naja naja venom & its inhibition by potassium gymnemate.
PubMed:
Time-dependent inhibition of sucrose sweetness with gymnemic acid: mode of action.
PubMed:
On the effects of gymnemic acid in the hamster and rat.
PubMed:
Sweetening agents from natural sources.
PubMed:
Effect of gymnemic acid on single taste hairs of the housefly, Musca domestica.
PubMed:
[Physiology of smell and taste].
PubMed:
Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on the isolation and heterogeneity of gymnemic acid A1.
PubMed:
Inhibition of ATPases by gymnemic acid.
PubMed:
Reduction of sucrose preference in the hamster by gymnemic acid.
PubMed:
Biological effects of Gymnema sylvestre fractions. II. Electrophysiology--effect of gymnemic acid on taste receptor response.