lithospermum erythrorhizon root oil CO2 extract
purple gromwell root oil CO2 extract
Identification
| Name | lithospermum erythrorhizon root oil CO2 extract |
| IUPAC | lithospermum erythrorhizon root oil CO2 extract |
| CAS Number | 223749-76-6 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Appearance | dark red liquid (est) |
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for lithospermum erythrorhizon root oil CO2 extract usage levels up to | not for fragrance use. |
| Recommendation for lithospermum erythrorhizon root oil CO2 extract flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
purple
gromwell root oil CO2 extract
red-root
gromwell root oil CO2 extract
lithospermum officinale var. erythrorhizon root oil CO2 extract
PubMed:
Pharmacological properties of shikonin - a review of literature since 2002.
PubMed:
Topical herbal formulae in the management of psoriasis: systematic review with meta-analysis of clinical studies and investigation of the pharmacological actions of the main herbs.
PubMed:
Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells.
PubMed:
Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy.
PubMed:
Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent.
PubMed:
Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice.
PubMed:
Shikonin attenuates lipopolysaccharide-induced acute lung injury in mice.
PubMed:
β,β-Dimethylacrylshikonin induces mitochondria dependent apoptosis through ERK pathway in human gastric cancer SGC-7901 cells.
PubMed:
Novel multiple apoptotic mechanism of shikonin in human glioma cells.
PubMed:
Inhibitory effects of β,β-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo.
PubMed:
Dermocosmetics for dry skin: a new role for botanical extracts.
PubMed:
Tigloylshikonin, a new minor Shikonin derivative, from the roots and the commercial root extract of lithospermum erythrorhizon.
PubMed:
In vitro screening of tumoricidal properties of international medicinal herbs: part II.
PubMed:
Lithospermic acid derivatives from Lithospermum erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells.
PubMed:
Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling.
PubMed:
Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications.
PubMed:
Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin.
PubMed:
Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells.
PubMed:
Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.
PubMed:
Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon.
PubMed:
Non-radioactive and colorimetric quantification of monocyte adhesion to endothelial cells in early atherogenesis.
PubMed:
Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages.
PubMed:
Caffeic acid metabolites from Eritrichium sericeum cell cultures.
PubMed:
Enhancement of natural pigment extraction using Bacillus species xylanase.
PubMed:
Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures.
PubMed:
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.
PubMed:
Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1.
PubMed:
High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon.
PubMed:
Cellular pharmacology studies of shikonin derivatives.
PubMed:
A novel dark-inducible protein, LeDI-2, and its involvement in root-specific secondary metabolism in Lithospermum erythrorhizon.
PubMed:
Reaction of beta-alkannin (shikonin) with reactive oxygen species: detection of beta-alkannin free radicals.
PubMed:
Genetic engineering on shikonin biosynthesis: expression of the bacterial ubiA gene in Lithospermum erythrorhizon.
PubMed:
Simultaneous analysis of shikimate-derived secondary metabolites in Lithospermum erythrorhizon cell suspension cultures by high-performance liquid chromatography.
PubMed:
Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures.
PubMed:
Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene.
PubMed:
Cell-specific production and antimicrobial activity of naphthoquinones in roots of lithospermum erythrorhizon
PubMed:
Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro.
PubMed:
cDNA cloning and gene expression of phenylalanine ammonia-lyase in Lithospermum erythrorhizon.
PubMed:
Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I.
PubMed:
Shikonin production by extractive cultivation in transformed-suspension and hairy root cultures of Lithospermum erythrorhizon.
PubMed:
[Screening test of crude drug extract on anti-HIV activity].
PubMed:
Shikonin production and secretion by hairy root cultures of Lithospermum erythrorhizon.
PubMed:
Betanin Production and Release In Vitro from Suspension Cultures of Beta vulgaris.