piperazine citrate

piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)

CAS: 144-29-6 C10 H18 N2 O7 MW: 278.26186000

Identification

Namepiperazine citrate
CAS Number144-29-6
EINECS205-622-8
FDA UNIIRI85381D5G
Molecular FormulaC10 H18 N2 O7
Molecular Weight278.26186000
MDL NumberMFCD00038961
Beilstein3777748

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 309.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000057 mmHg @ 25.00 °C. (est)
Flash Point 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w) -1.721 (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-child LDLo 260 mg/kg/3D-I
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for piperazine citrate usage levels up tonot for fragrance use.
Recommendation for piperazine citrate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

helmizin 2- hydroxy-1,2,3-propanetricarboxylate piperazine 2- hydroxypropane-1,2,3-tricarboxylic acid;piperazine multifuge citrate piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1) piperazine citrate anhydrous piperazine compound with citric acid piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) piperazine, citrate (3:2) PubMed: Piperazine citrate induced myoclonus in a child. PubMed: Phytochemical, anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb. PubMed: Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves. PubMed: Determination of anthelmintic activity of the leaf and bark extract of tamarindus indica linn. PubMed: A comparative study of the anthelmintic potential of cleome viscosa L. And cleome burmanni w. And a. PubMed: Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss. PubMed: Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives. PubMed: Studies on the anthelmintic property of aminobenzylated mannich bases. PubMed: Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles. PubMed: Evaluation of Anthelmintic Activities of Aerial Parts of Cynodon dactylon Pers. PubMed: Impact of subchronic administration of piperazine citrate on the electrocardiogram of the rat. PubMed: Evaluation of Anthelmintic Activity of Pistia stratiotes Linn. PubMed: Hypokalemic paralysis following severe vomiting in a child with intestinal obstruction due to round worms. PubMed: Piperazine protects the rat heart against sudden cardiac death from barium chloride-induced ventricular fibrillation. PubMed: Anti-inflammatory and anthelmintic activities of Solanum khasianum Clarke. PubMed: Human infection with Moniliformis moniliformis (Bremser 1811) (Travassos 1915) in Iran: another case report after three decades. PubMed: Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs. PubMed: Evaluation of anthelmintic activity of nuts of Semecarpus anacardium. PubMed: In Vitro Anthelmintic Activity of Baliospermum montanum Muell. Arg roots. PubMed: Time course of effect of piperazine citrate on the electrocardiogram of the rat. PubMed: Anthelmintic activity of leaves of justicia beddomei. PubMed: First total synthesis and biological screening of hymenamide E. PubMed: Anthelmintic activity of aerial parts of melothria heterophylla lour. PubMed: Occupational asthma due to piperazine citrate. PubMed: Electrocardiographic profile of oral piperazine citrate in healthy volunteers. PubMed: EVALUATION OF ANTHELMINTIC ACTIVITIES OF AERIAL PARTS of Celsia coromandeliane Vahl AND Mollugo pentaphylla Linn. PubMed: Unusual cerebellar ataxia: "worm wobble" revisited. PubMed: Comparison of practical treatment methods to eradicate pinworm (Dentostomella translucida) infections from Mongolian gerbils (Meroines unguiculatus). PubMed: Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid. PubMed: Management of intestinal obstruction caused by ascariasis. PubMed: Piperazine neurotoxicity: worm wobble revisited. PubMed: Ultrasound in the diagnosis of roundworms in gallbladder and common bile duct. Report of four cases. PubMed: Significant changes in gastrointestinal tract parasitic infections in children of St. Kitts over the 9-year period 1982-1991. PubMed: Surgical manifestations of ascariasis in childhood. PubMed: [Ascariasis of the gallbladder. Report of 2 cases and review of the literature]. PubMed: Endogenous formation of N-nitrosamines from piperazine and their urinary excretion following antihelmintic treatment with piperazine citrate. PubMed: A field evaluation of anthelmintics for control of cyathostomes of horses in Brazil. PubMed: Mebendazole poisoning in infancy. PubMed: Prevalence, incidence, intensity and associated morbidity of intestinal helminths in south Thailand. PubMed: Experimental chemotherapy in horses infected with benzimidazole-resistant small strongyles. PubMed: Antibodies to diethylcarbamazine cross-react with microfilariae of Wuchereria bancrofti. PubMed: Some effects of piperazine citrate on skeletal muscle and central nervous system. PubMed: Piperazine toxicity in Afghan puppies. PubMed: A comparison of the genetic activity of pyrvinium pamoate with that of several other anthelmintic drugs in Saccharomyces cerevisiae. PubMed: Mortality of captive tortoises due to viviparous nematodes of the genus Proatractis (Family Atractidae). PubMed: Piperazine toxicity in a kitten. PubMed: Biliary ascariasis: ultrasonography, endoscopic retrograde cholangiopancreatography, and biliary drainage. PubMed: [Determination of piperazine in hen eggs with HPLC following oral administration]. PubMed: Effect of Ascaris lumbricoides on zinc level in blood and urine. PubMed: Treatment of helminthic diseases. PubMed: Intestinal nematode infections. PubMed: Comparative antiarrhythmic and local anaesthetic effects of piperazine citrate and lignocaine hydrochloride. PubMed: Evaluation of febantel used concurrently with piperazine citrate in horses. PubMed: A comparative evaluation of mebendazole, piperazine and pyrantel in threadworm infection. Anthelmintic Study Group on Enterobiasis. PubMed: Effects of piperazine citrate and of the anti-Ascaris fraction of the ethanolic extract of the bark of Polyadoa umbellata (erin) on mammalian non-vascular smooth muscle. PubMed: Electrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle. PubMed: Prevention of the platelet alpha-granule release reaction by membrane-active drugs. PubMed: Single dose piperazine therapy for Ascaris lumbricoides: an unsuccessful method of promoting growth. PubMed: Hypocalcemic tetany induced by piperazine citrate in a mountain lion. PubMed: Erythema annulare centrifugum associated with ascariasis. PubMed: Controlled comparative study of the efficacy of pyrantel pamoate and a combined regimen of piperazine citrate and bephenium hydroxynaphthoate in the treatment of intestinal nemathelminthiases. PubMed: Piperazine toxicity in a new born. PubMed: Treatment of Syphacia obvelata in the Syrian hamster (Mesocricetus auratus) with piperazine citrate. PubMed: Absorption of macronutrients from a rice-vegetable diet before and after treatment of ascariasis in children. PubMed: Ascariasis and malnutrition. A study in urban Ethiopian children. PubMed: Eradication of the pinworm Syphacia obvelata from an animal unit by anthelmintic therapy. PubMed: Ethylenediamine sensitivity with a systemic reaction to piperazine citrate. PubMed: [Frequency of vulvovaginitis in girls with intestinal enterobiasis]. PubMed: An evaluation of levamisole for treatment of ascariasis. PubMed: Control of ascariasis by mass treatment with piperazine citrate. PubMed: Ascaris lumbricoides--a reminder. PubMed: Treatment of intestinal parasitic disease. PubMed: Quantitative determination of piperazine citrate in piperazine citrate syrup USP. PubMed: Human urinary excretion of piperazine citrate from syrup formulations. PubMed: Pyrantel pamoate in roundworm infestations: a comparative trial with piperazine citrate given in a single dose. PubMed: Levamisole in the treatment of ascariasis in children. PubMed: [The result of a single treatment with piperazine citrate in endemic infestation of Ascaris lumbricoides in Usambara, Tanzania]. PubMed: Comparative efficacy of levo-tetramisole, parbendazole, and piperazine citrate against some common helminths of turkeys. PubMed: Evaluation of the efficacy of methyridine, piperazine citrate and a worm pill for the elimination of Ascaridia galli infection in fowls in intensive confined system. PubMed: Obliquely striated muscle. 3. Contraction mechanism of Ascaris body muscle. PubMed: Single-dose treatment for Ascaris infection with piperazine citrate; with a study of the egg-parasite ratio. PubMed: Possible precipitation of petit mal seizures with piperazine citrate. PubMed: Some aspects of the pharmacology of piperazine citrate (Antepar) and of the anti-ascaris fraction of the ethanolic extract of the bark of the erin tree (Polyadoa umbellata-Dalziel). PubMed: A study of the efficacy of thiabendazole and dithiazanine iodide-piperazine citrate suspension against intestinal parasites in the Macaca mulatta. PubMed: [COLORIMETRIC DETERMINATION OF HETRAZAN, PIPERAZINE CITRATE, AND THEIR PREPARATIONS]. PubMed: [Results of the treatment of oxyuriasis with Adipinian and piperazine citrate in children's homes in Gdansk and Sopot]. PubMed: Effect of diethylcarbamazine, oxophenarsine hydrochloride and piperazine citrate on toxocara canis larvae in mice. PubMed: An evaluation of piperazine citrate for preventing prenatal infections with the common dog ascarid (Toxocara canis). PubMed: Two case histories of serum sickness-like reaction following piperazine citrate (antepar). PubMed: An acute urticarial reaction to piperazine citrate. PubMed: Efficacy of piperazine citrate in removing worms from the alimentary canal of cattle. PubMed: [Piperazine citrate in ascariasis associated with typhoid fever]. PubMed: On the single-dose treatment of ascariasis with piperazine citrate. PubMed: [Piperazine citrate in the management of ascariasis]. PubMed: Mass treatment of ascariasis with a single dose of piperazine citrate. PubMed: Preliminary studies on the anthelmintic properties of piperazine citrate in dogs. PubMed: The effectiveness of piperazine citrate against intestinal helminths of the cat and dog. PubMed: Treatment of multiple intestinal worm infections with piperazine citrate. PubMed: [Piperazine citrate for treatment of oxyuriasis]. PubMed: [Piperazine citrate and hexylresorcinol therapy of ascariasis; study of 157 cases]. PubMed: Treatment of ascariasis in children with a single dose of piperazine citrate. PubMed: Comparison of two regimes for the treatment of enterobiasis with piperazine citrate. PubMed: [Infections by Ascaris lumbricoides in children treated with piperazine citrate]. PubMed: Oxyuriasis: incidence in two socioeconomic groups of negro children; use of piperazine citrate in therapy. PubMed: [Anthelmintic effect of piperazine citrate on oxyria and ascarides]. PubMed: Anaphylactogenic properties of piperazine citrate. PubMed: The treatment of cases of ascariasis with piperazine citrate with observations of the effect of the drug on other helminthiases. PubMed: Treatment of roundworm with piperazine citrate: antepar. PubMed: Treatment of Ascaris lumbricoides infections with piperazine citrate.