piperazine citrate
piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
Identification
| Name | piperazine citrate |
| CAS Number | 144-29-6 |
| EINECS | 205-622-8 |
| FDA UNII | RI85381D5G |
| Molecular Formula | C10 H18 N2 O7 |
| Molecular Weight | 278.26186000 |
| MDL Number | MFCD00038961 |
| Beilstein | 3777748 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 309.60 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point | 311.00 °F. TCC ( 155.20 °C. ) (est) |
| logP (o/w) | -1.721 (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-child LDLo 260 mg/kg/3D-I |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for piperazine citrate usage levels up to | not for fragrance use. |
| Recommendation for piperazine citrate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
helmizin
2-
hydroxy-1,2,3-propanetricarboxylate piperazine
2-
hydroxypropane-1,2,3-tricarboxylic acid;piperazine
multifuge citrate
piperazine 2-hydroxypropane-1,2,3-tricarboxylate (1:1)
piperazine citrate anhydrous
piperazine compound with citric acid
piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)
piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2)
piperazine, citrate (3:2)
PubMed:
Piperazine citrate induced myoclonus in a child.
PubMed:
Phytochemical, anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb.
PubMed:
Anthelmintic and in vitro antioxidant evaluation of fractions of methanol extract of Leea asiatica leaves.
PubMed:
Determination of anthelmintic activity of the leaf and bark extract of tamarindus indica linn.
PubMed:
A comparative study of the anthelmintic potential of cleome viscosa L. And cleome burmanni w. And a.
PubMed:
Cytotoxic and anthelmintic potential of crude saponins isolated from Achillea Wilhelmsii C. Koch and Teucrium Stocksianum boiss.
PubMed:
Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives.
PubMed:
Studies on the anthelmintic property of aminobenzylated mannich bases.
PubMed:
Synthesis and anthelmintic activity of some novel 2-substituted-4,5-diphenyl imidazoles.
PubMed:
Evaluation of Anthelmintic Activities of Aerial Parts of Cynodon dactylon Pers.
PubMed:
Impact of subchronic administration of piperazine citrate on the electrocardiogram of the rat.
PubMed:
Evaluation of Anthelmintic Activity of Pistia stratiotes Linn.
PubMed:
Hypokalemic paralysis following severe vomiting in a child with intestinal obstruction due to round worms.
PubMed:
Piperazine protects the rat heart against sudden cardiac death from barium chloride-induced ventricular fibrillation.
PubMed:
Anti-inflammatory and anthelmintic activities of Solanum khasianum Clarke.
PubMed:
Human infection with Moniliformis moniliformis (Bremser 1811) (Travassos 1915) in Iran: another case report after three decades.
PubMed:
Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs.
PubMed:
Evaluation of anthelmintic activity of nuts of Semecarpus anacardium.
PubMed:
In Vitro Anthelmintic Activity of Baliospermum montanum Muell. Arg roots.
PubMed:
Time course of effect of piperazine citrate on the electrocardiogram of the rat.
PubMed:
Anthelmintic activity of leaves of justicia beddomei.
PubMed:
First total synthesis and biological screening of hymenamide E.
PubMed:
Anthelmintic activity of aerial parts of melothria heterophylla lour.
PubMed:
Occupational asthma due to piperazine citrate.
PubMed:
Electrocardiographic profile of oral piperazine citrate in healthy volunteers.
PubMed:
EVALUATION OF ANTHELMINTIC ACTIVITIES OF AERIAL PARTS of Celsia coromandeliane Vahl AND Mollugo pentaphylla Linn.
PubMed:
Unusual cerebellar ataxia: "worm wobble" revisited.
PubMed:
Comparison of practical treatment methods to eradicate pinworm (Dentostomella translucida) infections from Mongolian gerbils (Meroines unguiculatus).
PubMed:
Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid.
PubMed:
Management of intestinal obstruction caused by ascariasis.
PubMed:
Piperazine neurotoxicity: worm wobble revisited.
PubMed:
Ultrasound in the diagnosis of roundworms in gallbladder and common bile duct. Report of four cases.
PubMed:
Significant changes in gastrointestinal tract parasitic infections in children of St. Kitts over the 9-year period 1982-1991.
PubMed:
Surgical manifestations of ascariasis in childhood.
PubMed:
[Ascariasis of the gallbladder. Report of 2 cases and review of the literature].
PubMed:
Endogenous formation of N-nitrosamines from piperazine and their urinary excretion following antihelmintic treatment with piperazine citrate.
PubMed:
A field evaluation of anthelmintics for control of cyathostomes of horses in Brazil.
PubMed:
Mebendazole poisoning in infancy.
PubMed:
Prevalence, incidence, intensity and associated morbidity of intestinal helminths in south Thailand.
PubMed:
Experimental chemotherapy in horses infected with benzimidazole-resistant small strongyles.
PubMed:
Antibodies to diethylcarbamazine cross-react with microfilariae of Wuchereria bancrofti.
PubMed:
Some effects of piperazine citrate on skeletal muscle and central nervous system.
PubMed:
Piperazine toxicity in Afghan puppies.
PubMed:
A comparison of the genetic activity of pyrvinium pamoate with that of several other anthelmintic drugs in Saccharomyces cerevisiae.
PubMed:
Mortality of captive tortoises due to viviparous nematodes of the genus Proatractis (Family Atractidae).
PubMed:
Piperazine toxicity in a kitten.
PubMed:
Biliary ascariasis: ultrasonography, endoscopic retrograde cholangiopancreatography, and biliary drainage.
PubMed:
[Determination of piperazine in hen eggs with HPLC following oral administration].
PubMed:
Effect of Ascaris lumbricoides on zinc level in blood and urine.
PubMed:
Treatment of helminthic diseases.
PubMed:
Intestinal nematode infections.
PubMed:
Comparative antiarrhythmic and local anaesthetic effects of piperazine citrate and lignocaine hydrochloride.
PubMed:
Evaluation of febantel used concurrently with piperazine citrate in horses.
PubMed:
A comparative evaluation of mebendazole, piperazine and pyrantel in threadworm infection. Anthelmintic Study Group on Enterobiasis.
PubMed:
Effects of piperazine citrate and of the anti-Ascaris fraction of the ethanolic extract of the bark of Polyadoa umbellata (erin) on mammalian non-vascular smooth muscle.
PubMed:
Electrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle.
PubMed:
Prevention of the platelet alpha-granule release reaction by membrane-active drugs.
PubMed:
Single dose piperazine therapy for Ascaris lumbricoides: an unsuccessful method of promoting growth.
PubMed:
Hypocalcemic tetany induced by piperazine citrate in a mountain lion.
PubMed:
Erythema annulare centrifugum associated with ascariasis.
PubMed:
Controlled comparative study of the efficacy of pyrantel pamoate and a combined regimen of piperazine citrate and bephenium hydroxynaphthoate in the treatment of intestinal nemathelminthiases.
PubMed:
Piperazine toxicity in a new born.
PubMed:
Treatment of Syphacia obvelata in the Syrian hamster (Mesocricetus auratus) with piperazine citrate.
PubMed:
Absorption of macronutrients from a rice-vegetable diet before and after treatment of ascariasis in children.
PubMed:
Ascariasis and malnutrition. A study in urban Ethiopian children.
PubMed:
Eradication of the pinworm Syphacia obvelata from an animal unit by anthelmintic therapy.
PubMed:
Ethylenediamine sensitivity with a systemic reaction to piperazine citrate.
PubMed:
[Frequency of vulvovaginitis in girls with intestinal enterobiasis].
PubMed:
An evaluation of levamisole for treatment of ascariasis.
PubMed:
Control of ascariasis by mass treatment with piperazine citrate.
PubMed:
Ascaris lumbricoides--a reminder.
PubMed:
Treatment of intestinal parasitic disease.
PubMed:
Quantitative determination of piperazine citrate in piperazine citrate syrup USP.
PubMed:
Human urinary excretion of piperazine citrate from syrup formulations.
PubMed:
Pyrantel pamoate in roundworm infestations: a comparative trial with piperazine citrate given in a single dose.
PubMed:
Levamisole in the treatment of ascariasis in children.
PubMed:
[The result of a single treatment with piperazine citrate in endemic infestation of Ascaris lumbricoides in Usambara, Tanzania].
PubMed:
Comparative efficacy of levo-tetramisole, parbendazole, and piperazine citrate against some common helminths of turkeys.
PubMed:
Evaluation of the efficacy of methyridine, piperazine citrate and a worm pill for the elimination of Ascaridia galli infection in fowls in intensive confined system.
PubMed:
Obliquely striated muscle. 3. Contraction mechanism of Ascaris body muscle.
PubMed:
Single-dose treatment for Ascaris infection with piperazine citrate; with a study of the egg-parasite ratio.
PubMed:
Possible precipitation of petit mal seizures with piperazine citrate.
PubMed:
Some aspects of the pharmacology of piperazine citrate (Antepar) and of the anti-ascaris fraction of the ethanolic extract of the bark of the erin tree (Polyadoa umbellata-Dalziel).
PubMed:
A study of the efficacy of thiabendazole and dithiazanine iodide-piperazine citrate suspension against intestinal parasites in the Macaca mulatta.
PubMed:
[COLORIMETRIC DETERMINATION OF HETRAZAN, PIPERAZINE CITRATE, AND THEIR PREPARATIONS].
PubMed:
[Results of the treatment of oxyuriasis with Adipinian and piperazine citrate in children's homes in Gdansk and Sopot].
PubMed:
Effect of diethylcarbamazine, oxophenarsine hydrochloride and piperazine citrate on toxocara canis larvae in mice.
PubMed:
An evaluation of piperazine citrate for preventing prenatal infections with the common dog ascarid (Toxocara canis).
PubMed:
Two case histories of serum sickness-like reaction following piperazine citrate (antepar).
PubMed:
An acute urticarial reaction to piperazine citrate.
PubMed:
Efficacy of piperazine citrate in removing worms from the alimentary canal of cattle.
PubMed:
[Piperazine citrate in ascariasis associated with typhoid fever].
PubMed:
On the single-dose treatment of ascariasis with piperazine citrate.
PubMed:
[Piperazine citrate in the management of ascariasis].
PubMed:
Mass treatment of ascariasis with a single dose of piperazine citrate.
PubMed:
Preliminary studies on the anthelmintic properties of piperazine citrate in dogs.
PubMed:
The effectiveness of piperazine citrate against intestinal helminths of the cat and dog.
PubMed:
Treatment of multiple intestinal worm infections with piperazine citrate.
PubMed:
[Piperazine citrate for treatment of oxyuriasis].
PubMed:
[Piperazine citrate and hexylresorcinol therapy of ascariasis; study of 157 cases].
PubMed:
Treatment of ascariasis in children with a single dose of piperazine citrate.
PubMed:
Comparison of two regimes for the treatment of enterobiasis with piperazine citrate.
PubMed:
[Infections by Ascaris lumbricoides in children treated with piperazine citrate].
PubMed:
Oxyuriasis: incidence in two socioeconomic groups of negro children; use of piperazine citrate in therapy.
PubMed:
[Anthelmintic effect of piperazine citrate on oxyria and ascarides].
PubMed:
Anaphylactogenic properties of piperazine citrate.
PubMed:
The treatment of cases of ascariasis with piperazine citrate with observations of the effect of the drug on other helminthiases.
PubMed:
Treatment of roundworm with piperazine citrate: antepar.
PubMed:
Treatment of Ascaris lumbricoides infections with piperazine citrate.