ketoconazole

cis-1- acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1h-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine 1- acetyl-4-(4-{[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine 1-[4-[4-[[(2S,4R)-2-(2,4- dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone ethanone, 1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]- 1-(4-(4-(((2S,4R)-2-((1H- imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone (-)- ketoconazole (2S,4R)- ketoconazole piperazine, (-)-1-acetyl-4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]- PubMed: Liver injury associated with ketoconazole: Review of the published evidence. PubMed: Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers. PubMed: Combined administration of antibiotics and direct oral anticoagulants: a renewed indication for laboratory monitoring? PubMed: Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes. PubMed: Quantitative modelling to estimate the transfer of pharmaceuticals through the food production system. PubMed: Itraconazole and clarithromycin as ketoconazole alternatives for clinical CYP3A inhibition studies. PubMed: Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer. PubMed: Fungal toenail infections. PubMed: CYP3A4 activity reduces the cytotoxic effects of okadaic acid in HepaRG cells. PubMed: Ketoconazole in Cushing's disease: is it worth a try? PubMed: Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections. PubMed: Alogliptin: A new dipeptidyl peptidase-4 inhibitor for the management of type 2 diabetes mellitus. PubMed: Implantation phaeohyphomycosis caused by a non-sporulating Chaetomium species. PubMed: In vitro predictability of drug-drug interaction likelihood of P-glycoprotein-mediated efflux of dabigatran etexilate based on [I]2/IC50 threshold. PubMed: Candidiasis (oropharyngeal). PubMed: T-2 toxin is hydroxylated by chicken CYP3A37. PubMed: Ketoconazole modulates the infectivity of Ichthyophonus sp. (Mesomycetozoa) in vivo in experimentally injected European sea bass. PubMed: Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives. PubMed: Predictive value of cell assays for developmental toxicity and embryotoxicity of conazole fungicides. PubMed: Utility of a column-switching LC/MS/MS method in cytochrome P450 inhibition assays using human liver microsomes. PubMed: Clinical pharmacology of axitinib. PubMed: Skin conditions: common skin rashes in infants. PubMed: Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. PubMed: Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells. PubMed: Uptake of oxytetracycline, sulfamethoxazole and ketoconazole from fertilised soils by plants. PubMed: Telaprevir: pharmacokinetics and drug interactions. PubMed: Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics. PubMed: [The new anticoagulants - their role in secondary prevention of thromboembolism after stroke]. PubMed: Ascending single-dose study of the safety profile, tolerability, and pharmacokinetics of bosutinib coadministered with ketoconazole to healthy adult subjects. PubMed: A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds. PubMed: Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach. PubMed: Evaluation of the antifungal activity and modulation between Cajanus cajan (L.) Millsp. leaves and roots ethanolic extracts and conventional antifungals. PubMed: Comparison of three fluorescent CYP3A substrates in two vertebrate models: pig and Atlantic salmon. PubMed: Candidiasis (oropharyngeal). PubMed: Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.). PubMed: Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation. PubMed: Enhancement of β-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae. PubMed: A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects. PubMed: Vilazodone: clinical basis for the US Food and Drug Administration's approval of a new antidepressant. PubMed: Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report. PubMed: Fungal toenail infections. PubMed: Broadening horizons in medical management of prostate cancer. PubMed: Antimicrobial properties of Quercus ilex L. proanthocyanidin dimers and simple phenolics: evaluation of their synergistic activity with conventional antimicrobials and prediction of their pharmacokinetic profile. PubMed: Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors. PubMed: Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. PubMed: Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic. PubMed: Laser phototherapy for Stevens-Johnson syndrome: a case report. PubMed: Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4. PubMed: Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation. PubMed: Bioequivalence study of two formulations of 100 mg capsule of itraconazole. Quantification by tandem mass spectrometry. PubMed: Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats. PubMed: A review of clinical pharmacokinetics and pharmacodynamics of galantamine, a reversible acetylcholinesterase inhibitor for the treatment of Alzheimer's disease, in healthy subjects and patients. PubMed: Seborrhoeic dermatitis. PubMed: Prescriber compliance with black box warnings in older adult patients. PubMed: Justification for the use of Ocimum gratissimum L in herbal medicine and its interaction with disc antibiotics. PubMed: Estimation of intragastric drug solubility in the fed state: comparison of various media with data in aspirates. PubMed: Clinical pharmacokinetics and pharmacodynamics of solifenacin. PubMed: PCOS. PubMed: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. PubMed: Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power. PubMed: Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs. PubMed: Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design. PubMed: The need for multiple doses of 400 mg ketoconazole as a precipitant inhibitor of a CYP3A substrate in an in vivo drug-drug interaction study. PubMed: Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study. PubMed: CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides. PubMed: Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions. PubMed: Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers. PubMed: Fungal toenail infections. PubMed: Endocrine-disrupting properties in vivo of widely used azole fungicides. PubMed: 1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics. PubMed: Seborrhoeic dermatitis. PubMed: Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. PubMed: Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production. PubMed: The H295R system for evaluation of endocrine-disrupting effects. PubMed: Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents. PubMed: Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. PubMed: Clinical pharmacokinetics of ranolazine. PubMed: The clinical pharmacokinetics of darifenacin. PubMed: Secondary hormonal therapy for advanced prostate cancer. PubMed: Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections. PubMed: Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial. PubMed: pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model. PubMed: Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. PubMed: Exposure-response relationships and drug interactions of sirolimus. PubMed: Population-based case-control study of oral ketoconazole treatment for birth outcomes. PubMed: Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium. PubMed: Effect of fruit juices on the oral bioavailability of fexofenadine in rats. PubMed: Clinical pharmacology of bosentan, a dual endothelin receptor antagonist. PubMed: Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia. PubMed: The systemic treatment of onychomycosis. PubMed: Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease. PubMed: CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. PubMed: Comparative efficacies of oral ketoconazole and terbinafine for reducing Malassezia population sizes on the skin of Basset Hounds. PubMed: Desloratadine: A preclinical and clinical overview. PubMed: Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. PubMed: Lopinavir/ritonavir: a review of its use in the management of HIV infection. PubMed: Determination of clotrimazole in mice plasma by capillary electrophoresis. PubMed: Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. PubMed: Rabeprazole: pharmacokinetics and pharmacokinetic drug interactions. PubMed: Atopic dermatitis and fungi. PubMed: Application of modeling and simulation to integrate clinical pharmacology knowledge across a new drug application. PubMed: Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol. PubMed: Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo. PubMed: Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences. PubMed: Clinical pharmacokinetics of quetiapine: an atypical antipsychotic. PubMed: Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug. PubMed: Effects of ketoconazole on the acquisition of intravenous cocaine self-administration under different feeding conditions in rats. PubMed: Desloratadine: A new, nonsedating, oral antihistamine. PubMed: The pharmacologic profile of desloratadine: a review. PubMed: Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. PubMed: Oral griseofulvin remains the treatment of choice for tinea capitis in children. PubMed: Ketoconazole reduces low dose cocaine self-administration in rats. PubMed: Drug interactions with cisapride: clinical implications. PubMed: Cardiac effects of ebastine and other antihistamines in humans. PubMed: Pharmacokinetic and pharmacodynamic consequences of metabolism-based drug interactions with alprazolam, midazolam, and triazolam. PubMed: Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans. PubMed: Ketoconazole blocks the stress-induced reinstatement of cocaine-seeking behavior in rats: relationship to the discriminative stimulus effects of cocaine. PubMed: Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents. PubMed: Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole. PubMed: Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver. PubMed: A neuroendocrine role in cocaine reinforcement. PubMed: Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. PubMed: Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin. PubMed: Update on the management of onychomycosis: highlights of the Third Annual International Summit on Cutaneous Antifungal Therapy. PubMed: Diagnosis and treatment of tinea versicolor. PubMed: Coprescription of terfenadine and erythromycin or ketaconazole: an assessment of potential harm. PubMed: How 'bout that ritonavir? PubMed: Post-antibiotic effect and post-expositional polyene antagonism of azole antifungal agents in Candida albicans: dependence on substance lipophilia. PubMed: Innovative treatment approaches for rheumatoid arthritis. Cyclosporin, leflunomide and nitrogen mustard. PubMed: Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. PubMed: Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo PubMed: The systemic treatment of onychomycosis. PubMed: Metabolism of taxol by human and rat liver in vitro: a screen for drug interactions and interspecies differences. PubMed: Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme. PubMed: Effect of cimetidine, probenecid, and ketoconazole on the distribution, biliary secretion, and metabolism of [3H]taxol in the Sprague-Dawley rat. PubMed: Pharmacokinetic optimisation of oral antifungal therapy. PubMed: Is QT interval prolongation harmful? A regulatory perspective. PubMed: A banner year for AIDS therapy. PubMed: Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. PubMed: Resolution of generalized dermatophytosis without treatment in dogs. PubMed: Special drug communication teleconference. August 7, 1992. PubMed: Drug interactions: part II. PubMed: Is there a role for fluconazole in the treatment of vulvovaginal candidiasis? PubMed: Ketoconazole for treatment of dermatophytosis in cats. PubMed: Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis. PubMed: Impaired intestinal function in symptomatic HIV infection. PubMed: Azoles and AIDS. PubMed: Amphotericin-resistant aspergillus osteomyelitis controlled by itraconazole. PubMed: Diseases and drugs but not food decrease ketoconazole 'bioavailability'. PubMed: The effects of food and dose on the oral systemic availability of itraconazole in healthy subjects. PubMed: [Prevention of bacterial infections after bone marrow graft by broad-spectrum oral antibiotics, absorbable (pefloxacin, penicillin) and non absorbable (cephalosporin, gentamycin, bacitracin)]. PubMed: Effect of food and gastric acidity on absorption of orally administered ketoconazole. PubMed: Clinical pharmacokinetics of ketoconazole. PubMed: Effects of ketoconazole on cholesterol synthesis and precursor concentrations in the rat liver. PubMed: The influence of food on the pharmacokinetics of itraconazole in patients with superficial fungal infection. PubMed: Trichosporonosis in patients with neoplastic disease. PubMed: Pharmacologic review: a review of the literature of ketoconazole therapy in the treatment of tinea pedis and onychomycosis. PubMed: Hepatic injury associated with ketoconazole therapy. Analysis of 33 cases. PubMed: Influence of food on the pharmacokinetics of ketoconazole. PubMed: Multiple dose pharmacokinetics of ketoconazole and their effects on antipyrine kinetics in man. PubMed: Ketoconazole. PubMed: Prophylaxis of fungal infections in neutropenic cancer patients. PubMed: Hepatotoxic potential of ketoconazole under investigation. PubMed: Impairing effect of food on ketoconazole absorption. PubMed: Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients.