sanguinaria canadensis rhizome/root
bloodroot rhizome/root
Identification
| Name | sanguinaria canadensis rhizome/root |
| CAS Number | 84929-48-6 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for sanguinaria canadensis rhizome/root usage levels up to | not for fragrance use. |
| Recommendation for sanguinaria canadensis rhizome/root flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
blood root
bloodroot rhizome/root
red-
puccoon rhizome/root
sanguinaria australis rhizome/root
sanguinaria canadensis var. rotundifolia rhizome/root
sanguinaria dilleniana rhizome/root
sanguinaria rhizome/root
PubMed:
Bloodroot associated eschar.
PubMed:
In vitro screening of forty medicinal plant extracts from the United States Northern Great Plains for anthelmintic activity against Haemonchus contortus.
PubMed:
A review of topical corrosive black salve.
PubMed:
Hybrid poplar plantations are suitable habitat for reintroduced forest herbs with conservation status.
PubMed:
Signals can trump rewards in attracting seed-dispersing ants.
PubMed:
Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
PubMed:
Bloodroot.
PubMed:
Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial.
PubMed:
Rise and fall of oral health products with Canadian bloodroot extract.
PubMed:
Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway.
PubMed:
Consequences of intratumoral injection of a herbal preparation containing blood root (Sanguinaria canadensis) extract in two dogs.
PubMed:
The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus.
PubMed:
An Internet misadventure: bloodroot salve toxicity.
PubMed:
Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model.
PubMed:
Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3.
PubMed:
Human blood mononuclear cell in vitro cytokine response before and after two different strenuous exercise bouts in the presence of bloodroot and Echinacea extracts.
PubMed:
In vitro screening for the tumoricidal properties of international medicinal herbs.
PubMed:
Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation.
PubMed:
Histopathologic findings and diagnostic difficulties posed with use of escharotic agents for treatment of skin lesions: a case report and review of the literature.
PubMed:
Treating hot flushes in menopausal women with homeopathic treatment--results of an observational study.
PubMed:
Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL.
PubMed:
Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms.
PubMed:
Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.
PubMed:
Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix.
PubMed:
Sanguinarine inhibits VEGF-induced Akt phosphorylation.
PubMed:
HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae.
PubMed:
The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis.
PubMed:
Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).
PubMed:
Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization.
PubMed:
Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.
PubMed:
Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
PubMed:
Suppression of angiogenesis by the plant alkaloid, sanguinarine.
PubMed:
Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability.
PubMed:
Forest edges and fire ants alter the seed shadow of an ant-dispersed plant.
PubMed:
Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes.
PubMed:
In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis.
PubMed:
Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer.
PubMed:
Capillary electrophoresis of phytochemical substances.
PubMed:
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.
PubMed:
Environmental and genotypic influences on isoquinoline alkaloid content in Sanguinaria canadensis.
PubMed:
Elevational trends in defense chemistry, vegetation, and reproduction in Sanguinaria canadensis.
PubMed:
Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps.
PubMed:
Involvement of protein kinase and G proteins in the signal transduction of benzophenanthridine alkaloid biosynthesis.
PubMed:
Immunoblot analyses of the elicited Sanguinaria canadensis enzyme, dihydrobenzophenanthridine oxidase: evidence for resolution from a polyphenol oxidase isozyme.
PubMed:
Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures.
PubMed:
Quercetin-induced benzophenanthridine alkaloid production in suspension cell cultures of Sanguinaria canadensis.
PubMed:
Isolation and Characterization of S-Adenosyl-L-Methionine:Tetrahydroberberine-cis-N-Methyltransferase from Suspension Cultures of Sanguinaria canadensis L.
PubMed:
Differential enhancement of benzophenanthridine alkaloid content in cell suspension cultures of Sanguinaria canadensis under conditions of combined hormonal deprivation and fungal elicitation.
PubMed:
Purification and characterization of dihydrobenzophenanthridine oxidase from elicited Sanguinaria canadensis cell cultures.
PubMed:
Growth characteristics of Sanguinaria canadensis L. cell suspensions and immobilized cultures for production of benzophenanthridine alkaloids.
PubMed:
Characterization of Sanguinaria canadensis L. fluid extract by FAB mass spectrometry.
PubMed:
The history, chemistry and pharmacokinetics of Sanguinaria extract.
PubMed:
Antimicrobial action of sanguinarine.
PubMed:
Short-term toxicity studies of sanguinarine and of two alkaloid extracts of Sanguinaria canadensis L.
PubMed:
Plant tyrosine decarboxylase can be strongly inhibited by L-α-aminooxy-β-phenylpropionate.
PubMed:
Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+,K+-ATPase.
PubMed:
Biological and phytochemical evaluation of plants. 8. Isolation of a new alkaloid from Sanguinaria canadensis.
PubMed:
[Separation of sanguinarine and chelerythrine and additional plant bases of Sanguinaria canadensis].
PubMed:
ALKALOIDS FROM SANGUINARIA CANADENSIS AND THEIR INFLUENCE ON GROWTH OF PHYMATOTRICHUM OMNIVORUM.