piper methysticum root

root of the kawa-kawa, piper methysticum, piperaceae

CAS: 84696-40-2

Identification

Namepiper methysticum root
IUPACpiper methysticum root
CAS Number84696-40-2
FDA UNIISearch

Regulatory

Physical Properties

Food Chemicals Codex Listed No

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for piper methysticum root usage levels up tonot for fragrance use.
Recommendation for piper methysticum root flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

kava root

Synonyms

actiphyte of kava kava root kava root kava-kava root root of the kawa-kawa, piper methysticum, piperaceae PubMed: Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. PubMed: Kavain analogues as potential analgesic agents. PubMed: Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells. PubMed: Kava: a comprehensive review of efficacy, safety, and psychopharmacology. PubMed: Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. PubMed: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. PubMed: Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian. PubMed: Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products? PubMed: Kava consumption and its health effects. PubMed: Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. PubMed: In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum). PubMed: Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. PubMed: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard. PubMed: Analysis of plant extracts by NIRS: simultaneous determination of kavapyrones and water in dry extracts of Piper methysticum Forst. PubMed: Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. PubMed: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. PubMed: Kava does not display metabolic toxicity in a homogeneous cellular assay. PubMed: Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. PubMed: Hepatitis induced by Kava (Piper methysticum rhizoma). PubMed: Acute hepatitis induced by kava kava. PubMed: Kavain attenuates vascular contractility through inhibition of calcium channels. PubMed: Densitometric analysis of kawain in kava-kava root extracts. PubMed: Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses. PubMed: Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review. PubMed: Interaction of various Piper methysticum cultivars with CNS receptors in vitro. PubMed: Inhibition of haloperidol-induced catalepsy in rats by root extracts from Piper methysticum F. PubMed: [Treatment with Kava--the root to ocombat stress]. PubMed: Effects of (+/-)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats. PubMed: Kava dermopathy. PubMed: Identification by methane chemical ionization gas chromatography/mass spectrometry of the products obtained by steam distillation and aqueous acid extraction of commercial Piper methysticum.