piper methysticum root
root of the kawa-kawa, piper methysticum, piperaceae
Identification
| Name | piper methysticum root |
| IUPAC | piper methysticum root |
| CAS Number | 84696-40-2 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for piper methysticum root usage levels up to | not for fragrance use. |
| Recommendation for piper methysticum root flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
actiphyte of
kava kava root
kava root
kava-kava root
root of the kawa-kawa, piper methysticum, piperaceae
PubMed:
Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs.
PubMed:
Kavain analogues as potential analgesic agents.
PubMed:
Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells.
PubMed:
Kava: a comprehensive review of efficacy, safety, and psychopharmacology.
PubMed:
Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.
PubMed:
Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
PubMed:
Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.
PubMed:
Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?
PubMed:
Kava consumption and its health effects.
PubMed:
Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells.
PubMed:
In vitro cytotoxicity of nonpolar constituents from different parts of kava plant (Piper methysticum).
PubMed:
Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.
PubMed:
Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
PubMed:
Analysis of plant extracts by NIRS: simultaneous determination of kavapyrones and water in dry extracts of Piper methysticum Forst.
PubMed:
Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction.
PubMed:
Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
PubMed:
Kava does not display metabolic toxicity in a homogeneous cellular assay.
PubMed:
Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.
PubMed:
Hepatitis induced by Kava (Piper methysticum rhizoma).
PubMed:
Acute hepatitis induced by kava kava.
PubMed:
Kavain attenuates vascular contractility through inhibition of calcium channels.
PubMed:
Densitometric analysis of kawain in kava-kava root extracts.
PubMed:
Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses.
PubMed:
Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review.
PubMed:
Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
PubMed:
Inhibition of haloperidol-induced catalepsy in rats by root extracts from Piper methysticum F.
PubMed:
[Treatment with Kava--the root to ocombat stress].
PubMed:
Effects of (+/-)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats.
PubMed:
Kava dermopathy.
PubMed:
Identification by methane chemical ionization gas chromatography/mass spectrometry of the products obtained by steam distillation and aqueous acid extraction of commercial Piper methysticum.