nigella sativa seed tincture
black caraway seed tincture
Identification
| Name | nigella sativa seed tincture |
| CAS Number | 90064-32-7 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for nigella sativa seed tincture flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
black
caraway seed tincture
PubMed:
Scolicidal Effects of Black Cumin Seed (Nigella sativa) Essential Oil on Hydatid Cysts.
PubMed:
Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines.
PubMed:
Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro.
PubMed:
The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and PI3K pathways in rabbit articular chondrocytes.
PubMed:
Anti-microbial effect of Nigella sativa seed extract against staphylococcal skin Infection.
PubMed:
Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats.
PubMed:
Apoptotic Activities of Thymoquinone, an Active Ingredient of Black Seed (Nigella sativa), in Cervical Cancer Cell Lines.
PubMed:
Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway.
PubMed:
Potential protective effects of Nigella sativa and Allium sativum against fructose-induced metabolic syndrome in rats.
PubMed:
Mitigating role of thymoquinone rich fractions from Nigella sativa oil and its constituents, thymoquinone and limonene on lipidemic-oxidative injury in rats.
PubMed:
Dietary supplementation of chloroquine with nigella sativa seed and oil extracts in the treatment of malaria induced in mice with plasmodium berghei.
PubMed:
Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways.
PubMed:
Endothelium-independent vasorelaxant effects of hydroalcoholic extract from Nigella sativa seed in rat aorta: the roles of Ca2+ and K+ channels.
PubMed:
Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Srcâmediated phosphorylation of EGF receptor tyrosine kinase.
PubMed:
Stable isotope dilution gas chromatography-mass spectrometry for quantification of thymoquinone in black cumin seed oil.
PubMed:
Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial.
PubMed:
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα.
PubMed:
Induction of apolipoprotein A-I gene expression by black seed (Nigella sativa) extracts.
PubMed:
Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats.
PubMed:
Bioactivity-guided identification to delineate the immunomodulatory effects of methanolic extract of Nigella sativa seed on human peripheral blood mononuclear cells.
PubMed:
Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line.
PubMed:
Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes.
PubMed:
Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics.
PubMed:
Topical Nigella Sativa for nasal symptoms in elderly.
PubMed:
Authentication of Nigella sativa seed oil in binary and ternary mixtures with corn oil and soybean oil using FTIR spectroscopy coupled with partial least square.
PubMed:
Thymoquinone causes multiple effects, including cell death, on dividing plant cells.
PubMed:
The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury.
PubMed:
The effect of black seed (Nigella sativa) extract on FOXO3 expression in HepG2 cells.
PubMed:
Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.
PubMed:
Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.
PubMed:
Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro.
PubMed:
The investment in scent: time-resolved metabolic processes in developing volatile-producing Nigella sativa L. seeds.
PubMed:
Thymoquinone: fifty years of success in the battle against cancer models.
PubMed:
The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study.
PubMed:
Lepidium sativum but not Nigella sativa affects carbamazepine disposition in an animal model.
PubMed:
Comparative effects of using black seed (Nigella sativa), cumin seed (Cuminum cyminum), probiotic or prebiotic on growth performance, blood haematology and serum biochemistry of broiler chicks.
PubMed:
Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7.
PubMed:
Evaluation of topical black seed oil in the treatment of allergic rhinitis.
PubMed:
Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial.
PubMed:
Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration.
PubMed:
Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway.
PubMed:
Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia.
PubMed:
The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers.
PubMed:
Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.
PubMed:
Nigella sativa seed extract: 1. Enhancement of sheep macrophage immune functions in vitro.
PubMed:
Effects of selected bioactive natural products on the vascular endothelium.
PubMed:
Effects of black cumin seed (Nigella sativa L.) on performance and immune system in newly evolved crossbred laying hens.
PubMed:
Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats.
PubMed:
Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.
PubMed:
Effects of black seed oil on resolution of hepato-renal toxicity induced bybromobenzene in rats.
PubMed:
Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity.
PubMed:
Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis.
PubMed:
Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial.
PubMed:
Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs.
PubMed:
Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content.
PubMed:
Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin.
PubMed:
High-performance liquid chromatography quantification of principal antioxidants in black seed (Nigella sativa L.) phytopharmaceuticals.
PubMed:
NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.
PubMed:
Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses.
PubMed:
Cardiovascular benefits of black cumin (Nigella sativa).
PubMed:
Use of complementary and alternative medicine by patients with cancer in Saudi Arabia.
PubMed:
Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors.
PubMed:
Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?
PubMed:
Biosynthesis of controllable size and shape gold nanoparticles by black seed (Nigella sativa) extract.
PubMed:
The enhancing effects of alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and testosterone in male rats.
PubMed:
Cadmium-induced hepatotoxicity and its abrogation by thymoquinone.
PubMed:
Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice.
PubMed:
Characterization of secondary volatile profiles in Nigella sativa seeds from two different origins using accelerated solvent extraction and gas chromatography-mass spectrometry.
PubMed:
Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.
PubMed:
Stabilization of emulsion and butter like products containing essential fatty acids using kalonji seeds extract and curcuminoids.
PubMed:
Anticancer activity of Nigella sativa (black seed) - a review.
PubMed:
Upregulation of chemoprotective enzymes and glutathione by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats.
PubMed:
Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress.
PubMed:
Lindane-induced biochemical perturbations in rat serum and attenuation by omega-3 and Nigella sativa seed oil.
PubMed:
Antiatherogenic Potential of Nigella sativa Seeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits.
PubMed:
Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump.
PubMed:
Various extraction and analytical techniques for isolation and identification of secondary metabolites from Nigella sativa seeds.
PubMed:
The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content.
PubMed:
Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis.
PubMed:
Nigella sativa seed extract and its bioactive compound thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores.
PubMed:
Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation.
PubMed:
In vitro antituberculous activity of thymoquinone, an active principle of Nigella sativa.
PubMed:
Determination of oxygen radical absorbance capacity of black cumin (Nigella sativa) seed quinone compounds.
PubMed:
Investigation of lipids profiles of Nigella, lupin and artichoke seed oils to be used as healthy oils.
PubMed:
Validated high-performance thin-layer chromatographic method for the quantification of thymoquinone in Nigella Sativa extracts and formulations.
PubMed:
Phytochemical and biological investigation of the extracts of Nigella sativa L. seed waste.
PubMed:
In vitro antifungal effect of black cumin seed quinones against dairy spoilage yeasts at different acidity levels.
PubMed:
The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice.
PubMed:
Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide.
PubMed:
Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin.
PubMed:
Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats.
PubMed:
Review on molecular and therapeutic potential of thymoquinone in cancer.
PubMed:
Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats.
PubMed:
Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice.
PubMed:
Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in vitro.
PubMed:
Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia.
PubMed:
Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species.
PubMed:
Evaluation of immunomodulatory effect of three herbal plants growing in Egypt.
PubMed:
Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.
PubMed:
Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide.
PubMed:
Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients.
PubMed:
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
PubMed:
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.
PubMed:
Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats.
PubMed:
Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells.
PubMed:
Thymoquinone-induced relaxation of isolated rat pulmonary artery.
PubMed:
Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa.
PubMed:
Antimicrobial effect of garlic (Allium sativum).
PubMed:
Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells.
PubMed:
Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa.
PubMed:
Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells.
PubMed:
Anti bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus.
PubMed:
Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals.
PubMed:
Ancient nigella seeds from Boyali Höyük in north-central Turkey.
PubMed:
Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial.
PubMed:
Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species.
PubMed:
Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations.
PubMed:
Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats.
PubMed:
Black seed, Nigella sativa, deserves more attention.
PubMed:
Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats.
PubMed:
Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone - biomed 2009.
PubMed:
Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods.
PubMed:
HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone.
PubMed:
Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture.
PubMed:
Effect of different levels of feed added black seed (Nigella sativa L.) on the performance of broiler chicks.
PubMed:
Biological activity of seed aqueous extract of Nigella sativa (L.) on germination and seedling growth of Vigna radiata (L.).
PubMed:
Black cumin (Nigella sativa L.) supplementation into the diet of the laying hen positively influences egg yield parameters, shell quality, and decreases egg cholesterol.
PubMed:
From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond.
PubMed:
The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial.
PubMed:
Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension.
PubMed:
Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone.
PubMed:
Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors.
PubMed:
The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures.
PubMed:
Cardiac inotropic and hypertrophic effects of Nigella sativa supplementation in rats.
PubMed:
The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients.
PubMed:
The secret of the black seed: an ancient healing remedy for the modern healer.
PubMed:
Anti-tumor properties of blackseed (Nigella sativa L.) extracts.
PubMed:
A comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and thymoquinone, delivered by sustained drug delivery on colon cancer cells.
PubMed:
Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats.
PubMed:
Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2.
PubMed:
Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells.
PubMed:
An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols.
PubMed:
Immunomodulatory and therapeutic properties of the Nigella sativa L. seed.
PubMed:
Immunomodulating effects of black seed and oxytetracycline in pigeons.
PubMed:
Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice.
PubMed:
An investigation on LD50 and subacute hepatic toxicity of Nigella sativa seed extracts in mice.
PubMed:
Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone.
PubMed:
The effects of isolated antioxidants from black seed on the cellular metabolism of A549 cells.
PubMed:
Floral costs in Nigella sativa (Ranunculaceae): compensatory responses to perianth removal.
PubMed:
Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone.
PubMed:
Determination of isopropylmethylphenols in black seed oil by differential pulse voltammetry.
PubMed:
Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets.
PubMed:
Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism.
PubMed:
Effects of sustained delivery of thymoqiunone on bone healing of male rats.
PubMed:
Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug.
PubMed:
Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats.
PubMed:
Effects of Nigella sativa L. and Urtica dioica L. on selected mineral status and hematological values in CCl4-treated rats.
PubMed:
Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.
PubMed:
Radical scavenging activity of black cumin (Nigella sativa L.), coriander (Coriandrum sativum L.), and niger (Guizotia abyssinica Cass.) crude seed oils and oil fractions.
PubMed:
A simple differential pulse polarographic method for the determination of thymoquinone in black seed oil.
PubMed:
Thymoquinone-induced relaxation of guinea-pig isolated trachea.
PubMed:
The role of black seed in the proliferation and biochemical marker levels of Hep-2 cells.
PubMed:
Delayed apoptosis upon the treatment of Hep-2 cells with black seed.
PubMed:
Pharmacological and toxicological properties of Nigella sativa.
PubMed:
Characterization of phospholipid composition of black cumin (Nigella sativa L.) seed oil.
PubMed:
Response of broiler chicks to dietary Rhazya stricta and Nigella sativa.
PubMed:
Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping.
PubMed:
Effects of Nigella sativa fixed oil on blood homeostasis in rat.
PubMed:
Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.
PubMed:
Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection.
PubMed:
High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.).
PubMed:
Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone.
PubMed:
The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.
PubMed:
Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats.
PubMed:
The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action.
PubMed:
The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism(s) of action.
PubMed:
Studies on the antimicrobial activity of Nigella sativa seed (black cumin).
PubMed:
Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice.
PubMed:
Sterols in the seed oil of Nigella sativa.